Evaluation of hepatoprotective activity of aqueous extracts of leaves ofBasella albain albino rats

Abstract

This study was done to evaluate possible hepatoprotective effects of aqueous leaf extracts of Basella alba in comparison with silymarin in paracetamol-induced hepatotoxicity in albino rats. Six groups of six albino rats each received orally for 6 weeks, vehicle, paracetamol (2 g/kg/day), paracetamol (2 g/kg/day) plus silymarin (50 mg/kg/day), paracetamol (2 g/kg/day) plus B. alba extract (60 mg/kg/day), paracetamol (2 g/kg/day) plus B. alba extract (80 mg/kg/day) and paracetamol (2 g/kg/day) plus B. alba extract (100 mg/kg/day). Hepatoprotective effect was evaluated by comparing serum bilirubin, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, proteins, alkaline phosphatase and liver histopathology. Results were represented as mean ± SEM. One-way ANOVA was done followed by post hoc Tukey's test with a highly significance level of P < 0.001. Aqueous leaf extracts of B. alba 100 mg/kg/day orally had significant hepatoprotective effect in paracetamol-induced hepatotoxicity in albino rats. The results were well comparable and even in some respects superior to standard drug silymarin.

Therapeutic Potential of Plants and Plant Derived Phytochemicals against Acetaminophen-Induced Liver Injury

“…Further, very few of them demonstrated the prevention of the metabolic activation of APAP by suppressing CYP2E1, a plausible mechanism believed to alter the bioactivation of APAP. In studies employing phytochemicals/plant extracts to investigate APAP-induced hepatotoxicity, very few studies have been compared with silymarin as a positive reference phytochemical for the comparative evaluation of hepatoprotective effects [205,210,211,212]. This may be attributed to the huge variation observed in the dose (25–200 mg/kg) and the dosing regimen (1–15 days) of silymarin treatment.…”

Ameliorative Effects of Indigenous Medicinal Plants against Hepatic Diseases in Southern Region of India- A Review

“…The infectious agents or ingestion of toxic substances from food, chemicals, and over dose of drugs that cause liver damage are called hepato toxins [2,3] . It may be possible side effect of chronic medications or can be caused by chemicals such as microcystins, as well as artificial chemicals, like antibiotics of tetrachloride, chemotherapeutic agents, dimethyl nitrosamine, aflatoxin, CCl 4 , pyrrolizidine alkaloids, allyl alcohol, C 2 H 5 NS, biomobenzene [4,5] .…”

Evaluation of hepatoprotective activity of Boerhaavia diffusa against carbon tetrachloride induced liver toxicity in albino rats

“…Serum was separated after coagulating at 37°C for 30 mins and centrifuging at 2000 rpm for 15 mins, and estimated for serum ALT, serum AST, ALP and total serum proteins and total serum bilirubin using kits supplied by Bayer diagnostics India, Limited. 10 …”