Evaluation of hepatitis C, hepatitis B, and HIV virus Serology pandemic in thalassemia patients of Shahid Mohammadi Hospital of Bandar Abbas, Iran

Abstract

IntroductionThalassemia patients are prone to the hepatitis C, B, and HIV virus, due to their constant need to receive blood transfusions. Therefore, this research was aimed to determine the epidemic of the aforementioned diseases in thalassemia patients of Shahid Mohammadi Hospital of Bandar Abbas, Iran.MethodsThis cross-sectional study was carried out on thalassemia patients visiting the Thalassemia Hospital of Bandar Abbas from March 21, 2014, to March 22, 2015. Checklists were used to collect the data. HBS-Ag, HCV-Ab, and HIV-Ab tests have been registered for hepatitis B, hepatitis C, and HIV virus, respectively. The data were analyzed using SPSS 19 by Mann-Whitney U test, chi-square test, and independent samples t-test.ResultsAmong 587 records administered into the research, 280 individuals (47.7 %) were men and (52.3 %) were female. The average age of participants was 18.01 ± 9.31 years. The youngest was 1 years old, and the oldest was 46 years old. Four patients under the study (0.7 %) were positive for HBV; 60 (10.2 %) were HCV positive. However, no one in the study was diagnosed HIV positive. In the case of spread, there was no significant difference regarding age and sex in HBV patients. However, in HCV patients, significant differences were found (p=0.044 for gender and p=0.001 for age).ConclusionIn thalassemia, hepatitis C had the highest rate of spread. According to the screening, it was much anticipated that the trend should be falling, but the results show the contrary. Hence, it is recommended that more precise methods such as PCR be used.

Prevalence and Molecular Evaluation of Hepatitis C Virus Infection among Multi-transfused Thalassemia Patients in South of Iran

“…The anti-HCV seroprevalence reported in this study is higher than those observed among thalassemia patients in the other parts of Iran, 3.4% in Tabriz (North-West of Iran), 24 5.66% in Kurdistan (West of Iran), 25 8% in Isfahan (Center of Iran), 26 and 10.2% in Bandar Abbas (South-East of Iran), 27 but lower than 18.8% in Gilan and Mazandaran (North of Iran), 28 27.5% in Tehran (North-Center of Iran), 29 and 28.1% in Khuzestan (South-West of Iran). 30 According to a meta-analysis study, the overall seroprevalence of HCV among patients with thalassemia in Iran is 19%.…”

Evaluate microbial profile and IL-17 level in transmission transfusion infection patients

“…While (Surhan et al,2018) founded that 36.6% of thalassmeic patients sera was confirmed positive for anti-HCV-antibodies. In Iran (Aminianfar.,2017)reported that 0.7% of thalassemia patients were positive for HBV and 60 10.2% were positive for HCV. Dawood et al,(2020) in the province of Mosul explain that Iraq is one of the countries in the Middle East that has had an increased incidence of Hepatitis C infections over the past few years, and the increasing incidence can be observed in hemodialysis and thalassemia patients, due to the lack of health awareness among individuals, the failure of follow-up of new cases, and the deficiency of appropriate treatment in addition to the failure invention suitable vaccine .…”

Evaluate IL-10 level and gene polymorphism in β-Thalassemia patients with related to microbial infection and disease outcome

“…The results of this study show 41.3% of thalassemia patients were anti HCV sera-positive .This in line with local study by (ALbakaa et al,2020) observed that male more than female with frequency 53.57 , their ages range from (2-34) years and HCV PCR positive were ( 57.14 %) while (Surhan et al,2018) founded that 36.6% of thalassmeic patients sera was confirmed positive for anti-HCVantibodies. In Iran (Aminianfar., 2017) reported that 0.7% of thalassemia patients were positive for HBV and 60 10.2% were positive for HCV. Balouchi et al,(2014) showed a significant higher concentration of IL-10 ,TGF-β and IL-23 in the patient group than control group and concluded that several immunological abnormalities have been characterized in β-thalassemia which linked to cytokines .…”