Evaluation of hematological, biochemical parameters and thiol enzyme activity in chrome plating workers

Lacerda, Larissa Machado; Garcia, Solange Cristina; Silva, Luciano Basso da; Dornelles, Mariana de Ávila; Presotto, Anelise Teresinha; Lourenço, Eloir Dutra; Franceschi, Itiane Diehl de; Fernandes, Elissa Kerli; Wannmacher, Clóvis Milton Duval; Brucker, Natália; Saüer, Elisa; Gioda, Adriana; Machado, Aline Belem; Oliveira, Evandro; Trombini, Thereza Luciano; Feksa, Luciane Rosa

doi:10.1007/s11356-018-3755-7

Cited by 12 publications

(2 citation statements)

References 44 publications

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“…Potentially toxic elements related to cigarette smoking, including cadmium (Cd), lead (Pb), nickel (Ni), mercury (Hg), chromium (Cr) and arsenic (As), and essential elements, including calcium (Ca), magnesium (Mg), copper (Cu), iron (Fe), manganese (Mn), molybdenum (Mo), selenium (Se) and zinc (Zn), were determined in 500 μL of red blood cells mixed with 1 ml of 65% bi‐distilled nitric acid in a polypropylene tube. This mixture was heated at 95°C for 4 h, cooled at room temperature and diluted to 10 ml with ultrapure water . The concentrations of the elements were determined by inductively coupled plasma mass spectrometry (ICP‐MS) using a NexION 300X spectrometer (Perkin‐Elmer‐Sciex, Waltham, MA, USA).…”

Section: Methodsmentioning

confidence: 99%

Toxic elements in packed red blood cells from smoker donors: a risk for paediatric transfusion?

et al. 2019

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Background and ObjectivesSmokers currently have no defined restrictions for blood donation. However, cigarette smoke contains toxic substances such as carbon monoxide (CO) and trace elements that can affect the packed red blood cells (PRBCs) quality and safety of transfusion. This study evaluated the effects of smoking on the concentration of essential and trace elements and on carboxyhemoglobin (COHb) levels in PRBCs from smoker donors. Materials and MethodsA matched case-control study was conducted to compare COHb levels, determined by the CO-oximetry method, and levels of trace (Cd, Pb, Cr, Ni, As and Hg) and essential (Ca, Mg, Cu, Fe, Mn, Mo, Se and Zn) elements evaluated by inductively coupled plasma mass spectrometry, in PRBCs from smoker (n = 36) and non-smoker (n = 36) donors at Hospital de Cl ınicas de Porto Alegre, Brazil.Results Mean COHb level was 14 times higher in the PRBCs obtained from smoker donors (5Á9 [4Á0-9Á1] vs. 0Á4 [0Á2-0Á8]%). Cadmium (1Á0 [1Á0-1Á8] lg/l vs. undetectable) and lead (27 [21-36] vs. 19 [14-26] lg/l) levels were significantly higher in the PRBCs from smokers. Moreover, except for molybdenum, levels of all essential elements were lower in smoker PRBCs. ConclusionThe PRBCs donated by smokers contain toxic elements that are probably not safe for transfusion in children. Our results might support changes in the current guidelines of blood banks to improve the transfusion safety through inclusion of inquiry about smoking in the clinical screening, labelling and reserve PRBCs from smoker donors for adults or less critical recipients.

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Section: Methodsmentioning

confidence: 99%

Toxic elements in packed red blood cells from smoker donors: a risk for paediatric transfusion?

et al. 2019

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“…As a consequence of the wide application of Cr 6+ in the industry recently, the pollution of Cr 6+ has become more and more serious. A review has reported that Cr 6+ exposure is harmful to humans and animals by inducing various damages, such as lung cancer, nasal ulcers, allergic reactions, and contact rhinitis [ 32 ]. Therefore, it is very necessary to find a substance that can effectively antagonize Cr 6+ .…”

Section: Discussionmentioning

confidence: 99%

Selenium-Enriched Yeast Relieves Hexavalent Chromium Toxicity by Inhibiting NF-κB Signaling Pathway in Broiler Spleens

Zhao

Hao

Zhang

et al. 2022

Animals

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This study was conducted to investigate the molecular mechanisms of selenium (Se) antagonism of hexavalent chromium (Cr6+)-induced toxicity. Potassium dichromate (K2Cr2O7) and selenium-enriched yeast (SeY) were used to construct the single Cr6+ and combined Se/Cr6+ exposure broiler models, and then the broilers were randomly divided into four groups (C group, Se group, Se/Cr6+ group, and Cr6+ group). After a 42-day experiment, the spleen tissues of broilers were excised and weighted. The antagonistic mechanisms of Se and Cr6+ were evaluated using histopathological assessment, serum biochemical tests, oxidative stress kits, ELISA, qPCR, and Western blotting. On the whole, there were no significant changes between the C and Se groups. The spleen organ index in the Cr6+ group was significantly decreased, but SeY increased spleen organ index to a certain extent. The levels of SOD and GSH were reduced, and the MDA content was elevated by Cr6+; however, these changes were mitigated by Se/Cr6+ exposure. Importantly, Cr6+ exposure induced a series of histopathological injuries in broiler spleen tissues, while these symptoms were significantly relieved in the Se/Cr6+group. Furthermore, Cr6+ significantly decreased the levels of T-globulin, IgA, IgM, and IgG in serum. Contrarily, dramatically more T-globulin IgA, IgM, and IgG were found in the Se/Cr6+group than in the Cr6+ group. Revealed by the results of qPCR and WB, the expressions of NF-κB, IκBα, and p-IκBα were upregulated in Cr6+ groups, while they were downregulated in Se/Cr6+ group compared to that in Cr6+ group. Besides IFN-γ and IL-2, the expressions of pro-inflammatory cytokines were significantly increased by Cr6+ exposure, but the SeY supplement relived the expression levels mediated by Cr6+ exposure. In conclusion, our findings suggest SeY has biological activity that can protect broiler spleens from immunosuppression and inflammation induced by Cr6+, and we speculate that the NF-κB signaling pathway is one of its mechanisms.

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Heavy Metals: Source, Toxicity Mechanisms, Health Effects, Nanotoxicology and Their Bioremediation

Siddiqa

Faisal

2020

Contaminants in Agriculture

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Evaluation of hematological, biochemical parameters and thiol enzyme activity in chrome plating workers

Cited by 12 publications

References 44 publications

Toxic elements in packed red blood cells from smoker donors: a risk for paediatric transfusion?

Toxic elements in packed red blood cells from smoker donors: a risk for paediatric transfusion?

Selenium-Enriched Yeast Relieves Hexavalent Chromium Toxicity by Inhibiting NF-κB Signaling Pathway in Broiler Spleens

Heavy Metals: Source, Toxicity Mechanisms, Health Effects, Nanotoxicology and Their Bioremediation

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