Evaluation of haematological indices, neutrophils and platelets in pregnant women attending tertiary care centre

Dhariwal, Somendra Kumar; Narang, Sanjeev; Singh, Arjun Prasad; Nema, Shrikant

doi:10.5958/2394-6792.2016.00057.0

Cited by 6 publications

(4 citation statements)

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“…Also, the MCV and MCHC of pregnant women in this research were higher, which differ from some published studies that reported lower MCV and MCHC among the pregnant subjects. 16,19,20,21 In support of our finding, a prior study had stated that there is tendency for the MCV to be slightly elevated in pregnancy because of increased erythropoiesis. 8 Our analysis of variance used to assess the mean FBC among the three trimesters only revealed that with increasing gestational age, there was significant difference in MCH and MCHC.…”

Section: Discussionsupporting

confidence: 86%

“…The findings from this study are consistent with those from some earlier research. This includes increased TWBC; 15,16,17,18,19,20 increased neutrophils; 15,18,19,20,21 decreased RBC count; 15,16,21 decreased hemoglobin; 15,16,17,18,19,20,21 decreased PCV; 15,16,17,18,20,21 increased MCV; 15 increased MCH; 15 and reduced MCHC. 16 Although the mean platelet count was lower in pregnancy, this is not a significant finding in this research.…”

Section: Discussionmentioning

confidence: 99%

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Hematological Profile of Pregnant Women in Port Harcourt, Nigeria

Chinyelu

Jacob

Green

et al. 2019

Int. J. Transl Med Res Public Health

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BACKGROUND OR OBJECTIVES: Pregnant women experience a lot of changes, which often reflect in their hematological indices. The study examines the differences in the hematological profile of pregnant and nonpregnant women in Port Harcourt, in the Niger Delta region of Nigeria. METHODS: The subjects were systematically sampled, comprising of 90 pregnant and 90 non-pregnant women, with ages ranging 16 to 45 years. Five milliliters of whole blood was collected from each subject at ambient temperature using standard venepuncture techniques and three milliliters was dispensed in EDTA bottle. T-test was used to compare the mean of the parameters among the pregnant and nonpregnant women. Analysis of variance was used to compare the means for the parameters within the three trimesters. Tukey’s Post Hoc test was used to identify the trimester pairs that had significant mean difference, Hematological parameters were analyzed using Abacus380 hematological analyzer. The data obtained were coded and analysed using SPSS version 20 and data were considered significant at p≤0.05. RESULTS: Comparison of pregnant women with controls showed that Total White Blood Count TWBC), monocytes, neutrophils, Mean Cell Volume (MCV), and Mean Cell Hemoglobin (MCH) were significantly increased in pregnancy (p<0.05); while Red Blood Cell (RBC) count, hemoglobin, hematocrit and Mean Cell Hemoglobin concentration were significantly decreased (p<0.01). The following hematological parameters showed significant mean variation within the 3 trimesters: MCH (F=3.59, p=0.03) and MCHC (F=16.85, p<0.01). MCHC showed significant difference between first versus second trimesters (p=<0.01) and 1st vs. 3rd trimesters (p=<0.01). CONCLUSION AND IMPLICATIONS FOR TRANSLATION The lower hematocrit and hemoglobin level of pregnant women when compared with the non-pregnant controls implies that there is need for more emphasis on the importance of prenatal vitamin supplementation during the antenatal period, perhaps leveraging prenatal counselling sessions. Proper supplementation may avert anemia in pregnancy, and consequently, the poor birth outcomes. Key words: Hematological Profile • Pregnant Women • Nigeria • Pregnancy Copyright © 2019 Mba et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Hematological Profile of Pregnant Women in Port Harcourt, Nigeria

Chinyelu

Jacob

Green

et al. 2019

Int. J. Transl Med Res Public Health

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“…[16] However contrasting findings were seen in a study by Dhaliwal et al where there was no significant change in MCVvalues, on the other hand, MCHC and MHC showed significant decrease in pregnant women. [17] On further analyses five types of anemia were seen in anemic women based on peripheral blood examination as shown in Table 4. In our study majority of the pregnant women suffered from microcytic hypochromic anemia (71.1%), followed by 11.5% normocytic normochromic while dimorphic anemia was seen in 8.1% women, 7.5% had normocytic hypochromic and a miniscule of 1.7% had macrocytic picture.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Anemia and Hematological Parameters in Antenatal

Khetrapal

Jairajpuri

Rana

et al. 2018

APALM

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Materials and Methods A total of 173 pregnant female patients attending antenatal clinic, were analyzed in this study. All relevant data related to the patient's clinical presentation were collected. Venous blood samples were drawn from pregnant women attending antenatal clinic for the assessment of hematological parameters. EDTA tubes were used for adequate blood sample collection. The samples were analysed on three-part

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“…It is the result of an enhanced inflammatory response due to selective immune tolerance, immunosuppression, and immunomodulation of the fetus. A study by Dhariwal et al (2016) demonstrated a reduction in lymphocyte levels as the gestational weeks progressed. In recent years, the study of serological parameters has been used as a major marker for early diagnosis of pregnancy and the assessment of the occurrence of complications such as spontaneous preterm birth (sPTB).…”

Section: Introductionmentioning

confidence: 99%

Maternal Leukocytosis as Diagnostic Markers in Spontaneously Declared Preterm Birth

Koleva-Korkelia

2021

PMP

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Spontaneous preterm birth is the basic problem of perinatal mortality in Bulgaria. Pregnancy is characterized by physiological leukocytosis - determined by twice increased neutrophils levels, unchanged monocyte levels, and a reduction in the levels of lymphocytes, eosinophils, and basophils. The leukocytosis is particularly pronounced in the last trimester, due to physiological stress during pregnancy, and it is a result of the increased inflammatory response, a consequence of selective immune tolerance, immunosuppression, and fetus-immunomodulation. The objective of this study was to investigate and to appreciate maternal leukocytosis as potential diagnostic markers in spontaneously declared preterm birth and term birth declared cases. Methods: The case–control study was performed in UMBAL-City Hospital, Stara Zagora during 2017–2020. The study involved 200 patients, split into two groups: G1- the healthy pregnant women, n1=100 with а registered singleton pregnancy, at gestational age 37-39+6, gave birth on the term (TB); G2- the PTB patients, n2=100, confirmed clinically by cardiotocography for gestation >32 weeks. The highly sensitive Leuko-TIC-ELISA-WBC (upper limit of the normal number of Leuc during pregnancy - 15x109 per L) test was used for investigation. Blood samples were taken by puncture of the v.cubitalis in an anticoagulant at the time of hospitalization and examined within 1 hrs. Patients with systemic chronic illness and infections were excluded from the study. The results showed statistically significant Leuc reduction in SPTB patients (14.31±2.66×109/L, p>0.03), compared to the increased (14.67±3.21×109/L) (in normal-15x109L) Leuc values in the TB group.In conclusion, the results of the Leuc value confirm the presence of a systemic leukocytosis/oxidative inflammatory reaction at the time of declaring SPTB and TB.

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Evaluation of haematological indices, neutrophils and platelets in pregnant women attending tertiary care centre

Cited by 6 publications

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Hematological Profile of Pregnant Women in Port Harcourt, Nigeria

Hematological Profile of Pregnant Women in Port Harcourt, Nigeria

Evaluation of Anemia and Hematological Parameters in Antenatal

Maternal Leukocytosis as Diagnostic Markers in Spontaneously Declared Preterm Birth

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