Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases

Taoka, Toshiaki; Masutani, Yoshitaka; Kawai, Hisashi; Nakane, Toshiki; Matsuoka, Kiwamu; Yasuno, Fumihiko; Kishimoto, Toshifumi; Naganawa, Shinji

doi:10.1007/s11604-017-0617-z

Cited by 365 publications

(483 citation statements)

References 19 publications

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“…While glymphatic efflux of ISF has shown to play a vital role in the clearance of several metabolic waste products and other solutes such as Aβ and tau(15). Although this system has been predominately studied in rodents, the glymphatic system has also been demonstrated to exist in humans (16–19). …”

Section: Glymphatic Systemmentioning

confidence: 99%

“…It was also shown that CSF-derived Aβ could incorporate into established, endogenous Aβ plaques in older mice. Interestingly, a recently developed technique called “diffusion tensor image analysis along the perivascular space” (DTI-ALPS) was used to show that lower water diffusivity along the perivascular space of the medullary veins that run perpendicular to the lateral ventricle wall is negatively correlated with AD and mild cognitive impairment severity in humans(19). Although glymphatic function has never been formally studied in the context of CAA or CADASIL, taken together, these data point to a possible role for PVS obstruction secondary to protein aggregation in glymphatic impairment.…”

Section: Glymphatic Systemmentioning

confidence: 99%

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Perivascular spaces, glymphatic dysfunction, and small vessel disease

2017

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Cerebral small vessel diseases (SVD) range broadly in etiology but share a remarkably overlapping pathology. Features of SVD including enlarged perivascular spaces and formation of abluminal protein deposits cannot be completely explained by the putative pathophysiology. The recently discovered glymphatic system provides a new perspective to potentially address these gaps. This work provides a comprehensive review of the known factors that regulate glymphatic function and the disease mechanisms underlying glymphatic impairment emphasizing the role that aquaporin-4 (AQP4)-lined perivascular spaces, cerebrovascular pulsatility, and metabolite clearance play in normal CNS physiology. This review also discusses the implications that glymphatic impairment may have on SVD inception and progression with the aim of exploring novel therapeutic targets and highlighting the key questions that remain to be answered.

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Section: Glymphatic Systemmentioning

confidence: 99%

Section: Glymphatic Systemmentioning

confidence: 99%

Perivascular spaces, glymphatic dysfunction, and small vessel disease

2017

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“…Here we emphasize that 1) PVS is not an isotropic compartment and presents throughout the white matter, and 2) Efforts to eliminate fluid contributions may not be the right approach, as parameters obtained from this compartment could be an imaging signal of significant scientific value. For example, Taoka et al recently showed that diffusivity along the perivascular space may reflect impairment of the glymphatic system 52 . The extent to which these findings may be affected by the choice of the model is yet to be examined.…”

Section: Resultsmentioning

confidence: 99%

Perivascular space fluid contributes to diffusion tensor imaging changes in white matter

Sepehrband

Cabeen

Choupan

et al. 2018

Preprint

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Diffusion tensor imaging (DTI) has been extensively used to map changes in brain tissue related to neurological disorders. Among the most widespread DTI findings are increased mean diffusivity and decreased fractional anisotropy of white matter tissue in neurodegenerative diseases. We show that unincorporated anisotropic free water in perivascular space (PVS) significantly, and systematically, biases DTI measures, casting new light on the biological validity of many previously reported findings. Despite the challenge this poses for interpreting these past results, our findings suggest a new opportunity for incorporating the PVS contribution into diffusion MRI metrics of tissue changes, ultimately strengthening the clinical and scientific value of diffusion MRI.

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“…Contemporary clinical neuroscientists are trying to develop a safe and minimally invasive technique based on MRI imaging [21].…”

Section: Contemporary Possibilities Of Objective Estimation Of Thementioning

confidence: 99%

Significance of Understanding Function of Glymphatic System to Manage Practical Clinical Problems of the Elderly

2018

ARC Journal of Neuroscience

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Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases

Abstract: Activity of the glymphatic system may be evaluated with diffusion images. Lower diffusivity along the perivascular space on DTI-APLS seems to reflect impairment of the glymphatic system. This method may be useful for evaluating the activity of the glymphatic system.

Cited by 365 publications

References 19 publications

Perivascular spaces, glymphatic dysfunction, and small vessel disease

Perivascular spaces, glymphatic dysfunction, and small vessel disease

Perivascular space fluid contributes to diffusion tensor imaging changes in white matter

Significance of Understanding Function of Glymphatic System to Manage Practical Clinical Problems of the Elderly

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