Evaluation of glutathione S‐transferase pi 1 expression and gene promoter methylation in Moroccan patients with urothelial bladder cancer

Hadami, Khaoula; Dakka, Nadia; Bensaid, Mounia; Ahanidi, Hajar El; Ameur, A.; Chahdi, Hafsa; Oukabli, Mohamed; Bouzidi, Abderrahmane Al; Attaleb, Mohammed; Mzibri, Mohammed El

doi:10.1002/mgg3.449

Cited by 5 publications

(3 citation statements)

References 36 publications

(73 reference statements)

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“…One of which is the polymorphisms in CYP2D6 and CYP1A1 that have been studied in Egypt and Tunisia ( 321 – 323 ) and that of CYP2D*1A , which was found to increase the risk and clinicopathological outcome of both transitional and squamous cell carcinomas in Egypt ( 322 ). Similar findings were reported in the same North African countries for individuals with GST null genotypes and NAT*5 (341T>C) ( 324 – 331 ).…”

Section: Resultssupporting

confidence: 88%

A Review of Cancer Genetics and Genomics Studies in Africa

Rotimi

Salhia

2021

Front. Oncol.

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Cancer is the second leading cause of death globally and is projected to overtake infectious disease as the leading cause of mortality in Africa within the next two decades. Cancer is a group of genomic diseases that presents with intra- and inter-population unique phenotypes, with Black populations having the burden of morbidity and mortality for most types. At large, the prevention and treatment of cancers have been propelled by the understanding of the genetic make-up of the disease of mostly non-African populations. By the same token, there is a wide knowledge gap in understanding the underlying genetic causes of, and genomic alterations associated with, cancer among black Africans. Accordingly, we performed a review of the literature to survey existing studies on cancer genetics/genomics and curated findings pertaining to publications across multiple cancer types conducted on African populations. We used PubMed MeSH terms to retrieve the relevant publications from 1990 to December 2019. The metadata of these publications were extracted using R text mining packages: RISmed and Pubmed.mineR. The data showed that only 0.329% of cancer publications globally were on Africa, and only 0.016% were on cancer genetics/genomics from Africa. Although the most prevalent cancers in Africa are cancers of the breast, cervix, uterus, and prostate, publications representing breast, colorectal, liver, and blood cancers were the most frequent in our review. The most frequently reported cancer genes were BRCA1, BRCA2, and TP53. Next, the genes reported in the reviewed publications’ abstracts were extracted and annotated into three gene ontology classes. Genes in the cellular component class were mostly associated with cell part and organelle part, while those in biological process and molecular function classes were mainly associated with cell process, biological regulation, and binding, and catalytic activity, respectively. Overall, this review highlights the paucity of research on cancer genomics on African populations, identified gaps, and discussed the need for concerted efforts to encourage more research on cancer genomics in Africa.

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Section: Resultssupporting

confidence: 88%

A Review of Cancer Genetics and Genomics Studies in Africa

Rotimi

Salhia

2021

Front. Oncol.

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“…Among these, Ccnd1 was concurrently enriched in Wnt and p53 signaling pathways. Both Mgst1 44 and Gstp1 45 have been demonstrated to exert important functions in oxidative stress and tumorigenesis. Gsta1 is a Phase II detoxification enzyme involved in the biological progression of colorectal, lung, prostate, and bladder cancer, 46 and the relationship between cancer and Gsta2, 47 Gsta5, 48 and Adh1 48 has been reported.…”

Section: Discussionmentioning

confidence: 99%

Renal Transcriptomics Reveals the Carcinogenic Mechanism of Ethyl Carbamate in Musalais

Han¹,

Guo²,

Xiang³

2021

OTT

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Introduction Musalais is a traditional fermented wine produced in southern Xinjiang (a province of China) and is protected as a form of national intangible cultural heritage. However, ethyl carbamate (EC), which is naturally produced during the fermentation process, has been shown to induce carcinogenesis and was classified as a group 2A carcinogen by The World Health Organization’s International Agency for Research on Cancer. Methods In this work, rats were treated with musalais containing EC at varying contents (0.1, 1, or 10 mg/kg). To evaluate the toxicity of EC in musalais, the liver and kidney of the rats were subjected to transcriptomics sequencing. Differentially expressed genes (DEGs) between treated and untreated rats were identified, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis were performed on these genes to investigate the biological functions affected by EC in musalais. Results The results demonstrated that high EC content in musalais is possibly involved in the regulation of cytochrome P450 metabolism, chemical carcinogenesis, metabolism of xenobiotics by cytochrome P450, Wnt signaling, and p53 signaling by targeting Mgst1, Gstp1, Gsta5, Gsta1, Adh1, Gsta2, and Ccnd1, thereby inducing cancer. Conclusion The present work predicted the potential carcinogenic mechanism of high EC content in musalais, providing a reference for its safety evaluation.

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“…GSTP gene is mainly encoded in bronchial epithelial cells, colorectal cells, and B lymphocytes. [30]…”

Section: -Glutathione-s-transferase Pi (Gstp) Genementioning

confidence: 99%

Polymorphisms of Genes Related to Phase II Metabolism and Resistance to Clopidogrel

Alkattan

Alkhalifah²,

Alsalameen

et al. 2021

Pharmacogenomics

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Clopidogrel is an antiplatelet drug commonly used to prevent coagulation. This review aimed to investigate the effect of polymorphisms of G6PD, GCLC, GCLM, GSS, GST, GSR, HK and GLRX genes on clopidogrel during phase II metabolism through exploring previous studies. The results revealed that low glutathione plasma levels caused by several alleles related to these genes could affect the bioactivation process of the clopidogrel prodrug, making it unable to inhibit platelet aggregation perfectly and thus leading to severe consequences in patients with a high risk of blood coagulation. However, the study recommends platelet reactivity tests to predict clopidogrel efficacy rather than studying gene mutations, as most of these mutations are rare and other nongenetic factors could affect the drug’s efficacy.

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Evaluation of glutathione S‐transferase pi 1 expression and gene promoter methylation in Moroccan patients with urothelial bladder cancer

Cited by 5 publications

References 36 publications

A Review of Cancer Genetics and Genomics Studies in Africa

A Review of Cancer Genetics and Genomics Studies in Africa

Renal Transcriptomics Reveals the Carcinogenic Mechanism of Ethyl Carbamate in Musalais

Polymorphisms of Genes Related to Phase II Metabolism and Resistance to Clopidogrel

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