Evaluation of Glaucoma Progression in Large-Scale Clinical Data: The Japanese Archive of Multicentral Databases in Glaucoma (JAMDIG)

Abstract

Age and the degree of VF damage were related to future progression. Average IOP was not related to the progression rate; however, fluctuation of IOP was associated with faster progression, although this was not the case when average IOP was below 15 mm Hg.

Effects of ocular and systemic factors on the progression of glaucomatous visual field damage in various sectors

“…As discussed in our previous report,4 these values are lower than found in other studies performed in real-world clinics 11 12. Indeed, the VF progression rate observed in the present study is close to a previous observational study (−0.25 dB/year) in post-trabeculectomy patients with a maximum IOP of 12 mm Hg (mean 10.3 mm Hg),13 and is markedly lower than the natural history progression rate reported in the Collaborative Normal-Tension Glaucoma Study randomised control trial of normal-tension glaucomatous eyes (∼−0.4 dB/year) 6…”

“…In Japan, we have developed a large database of patients with glaucoma obtained from nine institutes known as the ‘Japanese Archive of Multicentral Databases in Glaucoma’ (JAMDIG) 4. Using this dataset, we have previously explored the effects of age, the degree of damage in the baseline visual field (VF), the average intraocular pressure (IOP) during follow-up, the SD of IOP during follow-up, previous argon/selective laser trabeculoplasties, previous trabeculectomy and previous trabeculotomy on the progression of VF damage.…”

Investigating the usefulness of a cluster-based trend analysis to detect visual field progression in patients with open-angle glaucoma

“…All of the data analysed in the current study were drawn from the JAMDIG 13. JAMDIG is a database collected from eight institutes in Japan, as introduced in the online supplementary appendix.…”

“…JAMDIG is a database collected from eight institutes in Japan, as introduced in the online supplementary appendix. The details of the database are given elsewhere 13. In short, all VF data satisfying the inclusion criteria below were retrospectively collected from the electronic records of each institute: (1) eyes with primary open angle glaucoma (POAG) including normal tension glaucoma (NTG), (2) glaucoma was the only disease causing VF damage, (3) each eye had at least 10 VF measurements with 24–2 or 30–2 Humphrey Field Analyzer using the SITA standard programme (HFA; Carl Zeiss Meditec, Dublin, California, USA), excluding one baseline VF.…”

“…In this study, the usefulness of a cluster trend analysis was investigated and compared with an mTD trend analysis. We have recently developed a multicentral retrospective collection of glaucomatous VFs known as the Japan Archives of Multicentral Database In Glaucoma (JAMDIG),13 and the current investigation was performed using this data set.…”