Evaluation of Ginger (
            <i>Zingiber Officinale Roscoe</i>
            ) on Energy Metabolism and Obesity: Systematic Review and Meta-Analysis

Macit, Melahat Sedanur; Sözlü, Saniye; Kocaadam, Betül; Tek, Nilüfer Acar

doi:10.1080/87559129.2019.1608556

Cited by 8 publications

(6 citation statements)

References 40 publications

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“…Nine systematic reviews ( 2 , 3 , 30–32 , 34 , 35 , 47 , 48 ) explored the effect of ginger on 3 metabolic conditions. The overall finding was consistent evidence of a moderate to large beneficial effect for cardiovascular health, glycemic control, and weight management.…”

Section: Resultsmentioning

confidence: 99%

“…Concerning weight management, there was some evidence that ginger in comparison with placebo reduced body weight and BMI (effect size: large; GRADE level: low) as well as hip circumference and waist-to-hip ratio (effect size: small to medium; GRADE: moderate) ( 34 ). Although meta-analyses were not conducted, 3 (75%) of the primary studies that assessed appetite, 2 (67%) of the primary studies that assessed food intake, 2 (100%) studies that measured fullness, and 3 (100%) studies that examined energy intake or thermogenesis found no statistically significant positive effects with ginger consumption ( 2 , 30 , 47 ).…”

Section: Resultsmentioning

confidence: 99%

“…Seven (29%) systematic reviews only included placebo-controlled trials ( 30 , 34 , 38 , 42–45 ) and the remaining systematic reviews mainly examined a combination of placebo, usual care, or a medicine as the comparator with ginger. Zingiber officinale was examined in the primary studies of 11 (46%) systematic reviews ( 30 , 32 , 34 , 37–39 , 41 , 44 , 45 , 47 , 48 ) and the remaining 13 (54%) reviews did not specify the species of ginger administered. Most systematic reviews explored multiple forms of ginger consumption, but ginger capsules were the most commonly administered [ n = 14 (58%) systematic reviews] ( 2 , 29 , 32 , 33 , 36 , 39–42 , 45 , 46 , 48–50 ) followed by ginger powder [ n = 6 (25%) of systematic reviews; Table 2 ] ( 30 , 31 , 34 , 35 , 37 , 38 ).…”

Section: Resultsmentioning

confidence: 99%

“…Interventions of ≤10 d duration were most commonly used in primary studies of the 6 systematic reviews that examined the analgesic effects of ginger for dysmenorrhea or headache ( 2 , 29 , 36 , 41 , 42 , 45 ). Primary studies of the 8 systematic reviews that examined the metabolic effects of ginger commonly administered ginger for longer durations of 6 wk to 3 mo ( 2 , 30–32 , 34 , 35 , 47 , 48 ). Duration of intervention ranged from 1 d to 3 mo for all other outcomes and population groups.…”

Section: Resultsmentioning

confidence: 99%

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Orally consumed ginger and human health: an umbrella review

Crichton

Davidson

Innerarity

et al. 2022

The American Journal of Clinical Nutrition

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Background Emerging evidence supports the health benefits of ginger for a range of conditions and symptoms; however, there is a lack of synthesis of literature to determine which health indications are supported by quality evidence. Objectives This umbrella review of systematic reviews aimed to determine the therapeutic effects and safety of any type of ginger from the Zingiber family administered in oral form compared with any comparator or baseline measures on any health and wellbeing outcome in humans. Design Five databases were searched to April 2021. Review selection and quality was assessed in duplicate using the Assessment of Multiple Systematic Reviews-2 (AMSTAR-2) Checklist and the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) method, with results presented narratively. Results Twenty-four systematic reviews were included with 3% overlap of primary studies. Strongest evidence was found for the antiemetic effects of ginger in pregnant women (effect size: large; GRADE: high), analgesic effects for osteoarthritis (effect size: small; GRADE: high), and glycemic control (effect size: none-to-very large; GRADE: very low-to-moderate). Ginger also had a statistically significant positive effect on blood pressure, weight management, dysmenorrhea, post-operative nausea, and chemotherapy-induced vomiting (effect size: moderate-to-large; GRADE: low-to-moderate) as well as blood lipid profile (effect size: small; GRADE: very low) and anti-inflammatory and antioxidant biomarkers (effect size: unclear; GRADE: very low-to-moderate). There was substantial heterogeneity and poor reporting of interventions; however, doses of 0.5–3 g per day in capsule form administered for up to three months was consistently reported as effective. Conclusions Dietary consumption of ginger appears safe and may exert beneficial effects on human health and wellbeing, with greatest confidence in antiemetic effects in pregnant women, analgesic effects in osteoarthritis, and glycemic control. Future randomized controlled and dose-dependent trials with adequate sample sizes and standardized ginger products are warranted to better inform and standardize routine clinical prescription. Registration: International Prospective Register of Systematic Reviews (PROSPERO) ID: CRD42020197925.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Orally consumed ginger and human health: an umbrella review

Crichton

Davidson

Innerarity

et al. 2022

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

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“…Nevertheless, previous animal studies showed significant effects of ginger on obesity [ 46 , 47 ]. However, there is controversy about the beneficial effects of ginger on obesity in human studies [ 48 , 49 ], which may be due to differences in participants, duration, and the dose and pharmaceutical form of ginger. Similar to our study, Attari et al illustrated that the administration of 2 g of ginger for 12 weeks in obese women significantly reduced the BMI and waist circumference compared with the baseline and the placebo group [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Ginger Supplementation in Relieving Persistent Hypothyroid Symptoms in Patients with Controlled Primary Hypothyroidism: A Pilot Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Ashraf

Heydari

Shams

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Primary hypothyroidism is a common disease. Some patients have persistent symptoms despite normal serum thyroid-stimulating hormone (TSH) levels. Ginger is reported to be beneficial in relieving similar symptoms. Our aim was to evaluate the efficacy of ginger supplementation in relieving persistent symptoms in these patients. In this randomized, double-blind, placebo-controlled clinical trial, 60 hypothyroid patients aged 20–60 years with normal serum TSH concentrations were randomly allocated to two equal parallel study groups of ginger (500 mg twice a day) or placebo for 30 days. Hypothyroid symptoms were evaluated as the primary outcome using the Thyroid Symptom Rating Questionnaire (ThySRQ) before and after the intervention. Anthropometric measures and laboratory indices including TSH, triglyceride (TG), total cholesterol (TChol), and fasting blood sugar (FBS) were considered as secondary outcomes. A significant lower mean total ThySRQ score (8.63 ± 5.47 vs. 15.76 ± 6.09, P < 0.001 ) was observed in the ginger group compared to the control group. Ginger led to significant improvements in the mean scores of the weight gain, cold intolerance, constipation, dry skin, appetite, memory loss, concentration disturbance, and feeling giddy or dizzy domains ( P < 0.001 ). However, no significant improvements were observed in hair loss, nail fragility, hearing, hoarseness, speech, and depression or feeling down ( P > 0.05 ). Ginger supplementation also led to a significant decrease in body weight, body mass index, waist circumference, serum TSH, FBS, TG, and TChol levels compared to the placebo. In summary according to preliminary results of this study, ginger supplementation can help relieve persistent hypothyroid symptoms. Also, it may have beneficial effects in terms of weight reduction and regulation of the FBS and lipid profile in hypothyroid patients.

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Integrated network pharmacology and cellular assay for the investigation of an anti-obesity effect of 6-shogaol

Jiao

Sang

et al. 2022

Food Chemistry

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Evaluation of Ginger ( Zingiber Officinale Roscoe ) on Energy Metabolism and Obesity: Systematic Review and Meta-Analysis

Cited by 8 publications

References 40 publications

Orally consumed ginger and human health: an umbrella review

Orally consumed ginger and human health: an umbrella review

Efficacy of Ginger Supplementation in Relieving Persistent Hypothyroid Symptoms in Patients with Controlled Primary Hypothyroidism: A Pilot Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Integrated network pharmacology and cellular assay for the investigation of an anti-obesity effect of 6-shogaol

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