Evaluation of genotoxic effects of oral exposure to Aluminum oxide nanomaterials in rat bone marrow

Balasubramanyam, Ashok; Sailaja, N.; Mahboob, M.; Rahman, M. F.; Misra, Sunil; Hussain, Saber M.; Grover, Paramjit

doi:10.1016/j.mrgentox.2009.03.004

Cited by 77 publications

(55 citation statements)

References 36 publications

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“…Nanoparticles have also been found to cause genotoxicity in bone marrow cells after exposure in animals. 172,173 This finding is discussed in the section on hematopoietic toxicity. In vitro evaluation.…”

Section: Nanotoxicity To Bonesmentioning

confidence: 92%

“…412 We summarize the characterization of nanoparticles and the cell models used in all of these studies in Table 5. The genotoxic potential of other nanoparticles, such as QD, 414 nanodiamonds, 413 aluminum oxide, 172 cobalt, 400 cobalt chrome alloy, 415 and maghemite nanoparticles, 416 have also been investigated. However, comparison of these results is difficult because of the great differences in the experimental protocols used.…”

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confidence: 99%

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Perturbation of physiological systems by nanoparticles

et al. 2014

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Nanotechnology is having a tremendous impact on our society. However, societal concerns about human safety under nanoparticle exposure may derail the broad application of this promising technology. Nanoparticles may enter the human body via various routes, including respiratory pathways, the digestive tract, skin contact, intravenous injection, and implantation. After absorption, nanoparticles are carried to distal organs by the bloodstream and the lymphatic system. During this process, they interact with biological molecules and perturb physiological systems. Although some ingested or absorbed nanoparticles are eliminated, others remain in the body for a long time. The human body is composed of multiple systems that work together to maintain physiological homeostasis. The unexpected invasion of these systems by nanoparticles disturbs normal cell signaling, impairs cell and organ functions, and may even cause pathological disorders. This review examines the comprehensive health risks of exposure to nanoparticles by discussing how nanoparticles perturb various physiological systems as revealed by animal studies. The potential toxicity of nanoparticles to each physiological system and the implications of disrupting the balance among systems are emphasized.

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Section: Nanotoxicity To Bonesmentioning

confidence: 92%

mentioning

confidence: 99%

Perturbation of physiological systems by nanoparticles

et al. 2014

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“…Engineered aluminium (Al)-based NPs were investigated in vivo by Balasubramanyam et al (42,43). In orally exposed rats, the authors observed signifi cant dose related DNA breakage, dose dependent micronuclei formation, and chromosome aberrations by 30 nm and 40 nm aluminium oxide (Al 2 O 3 ) NPs.…”

Section: Genotoxic Potential Of Aluminium Npsmentioning

confidence: 99%

Genotoxicity of Metal Nanoparticles: Focus on In Vivo Studies

Klien

Godnič‐Cvar

2012

Archives of Industrial Hygiene and Toxicology

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With increasing production and application of a variety of nanomaterials (NMs), research on their cytotoxic and genotoxic potential grows, as the exposure to these nano-sized materials may potentially result in adverse health effects. In large part, indications for potential DNA damaging effects of nanoparticles (NPs) originate from inconsistent in vitro studies. To clarify these effects, the implementation of in vivo studies has been emphasised. This paper summarises study results of genotoxic effects of NPs, which are available in the recent literature. They provide indications that some NP types cause both DNA strand breaks and chromosomal damages in experimental animals. Their genotoxic effects, however, do not depend only on particle size, surface modifi cation (particle coating), and exposure route, but also on exposure duration. Currently available animal studies may suggest differing mechanisms (depending on the duration of exposure) by which living organisms react to NP contact. Nevertheless, due to considerable inconsistencies in the recent literature and the lack of standardised test methods -a reliable hazard assessment of NMs is still limited. Therefore, international organisations (e.g. NIOSH) suggest utmost caution when potential exposure of humans to NMs occurs, as long as evidence of their toxicological and genotoxic effect(s) is limited.

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“…In the case of Al 2 O 3 NPs, reports are even more limited. Rat bone marrow [14] and alveolar macrophages (NR8383) [15] were used. Lower toxicity of Al 2 O 3 NPs than Al NPs was found.…”

Section: Introductionmentioning

confidence: 99%