Evaluation of gastroprotective activity of Plinia edulis (Vell.) Sobral (Myrtaceae) leaves in rats

Antiulcerogenic activity of the essential oil of Hyptis martiusii Benth. (Lamiaceae)

“…The potential antiulcerogenic of several terpenoids have been evaluated, including triterpene oleanolic acid (Astudillo et al, 2002) and acetyl-aleuritolic acid (Pertino et al, 2007), sesquiterpene lactone trans-crotonin (Hiruma-Lima et al, 2002), diterpene ferruginol (Rodriguez et al, 2006), and monoterpene limonene and 1,8-cineole (Santos and Rao, 2001;Moraes et al, 2009). Some studies have pointed out that the gastroprotective activity of terpenoids may particularly involve reinforcement of defensive factors of the gastric mucosa (Ishikawa et al, 2008).…”

Anti-Inflammatory Effects ofHyptis albidaChloroform Extract on Lipopolysaccharide-Stimulated Peritoneal Macrophages

“…Several authors have reported that ursolic acid suppresses the expression of the proinflammatory enzymes, COX-2 and iNOS [43], and inhibits the production of NO in macrophages [44] and NF- κ B activation [45]. Some studies have indicated that some terpenoids have gastroprotective activity that involves reinforcement of defensive factors in the gastric mucosa [46]. On the other hand, flavonoids modulate the activities of arachidonic acid (AA) metabolizing enzymes such as phospholipase A 2 (PLA 2 ) [47, 48], COX-2 [49], and lipoxygenase (LOX) [50–52] and iNOS [53].…”

Tecnologias em pesquisa: ciências exatas e biológicas

“…Também tem despertado a atenção da indústria farmacêutica, pois suas frutas são ricas em vitaminas e em substâncias antioxidantes (HU, et al, 2012;STEFANELLO, et al, 2011;FRANZON, 2009;ISHIKAWA, et al,2008). Em sua composição química destaca-se a presença de flavonoides, terpenoides,taninos e derivados fenólicos (LAGO, et al, 2011).…”