Antiulcerogenic activity of the essential oil of Hyptis martiusii Benth. (Lamiaceae)

Caldas, Germana Freire Rocha; Costa, Iggor Macêdo do Amaral; Silva, Juciene Bezerra Rodrigues da; Nóbrega, Rafaella Farias da; Rodrigues, Fabíola Fernandes Galvão; Costa, José Galberto Martins da; Wanderley, Almir Gonçalves

doi:10.1016/j.jep.2011.07.005

Cited by 43 publications

(41 citation statements)

References 33 publications

(30 reference statements)

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“…The gastroprotective activity of the essential oil from the leaves of Hyptis martiusii was shown recently by our research group [15], confirming its ethnomedicinal use. In this study, we have assessed for the first time the repeated doses toxicity of the essential oil of the leaves of Hyptis martiusii (EOHM).…”

Section: Discussionsupporting

confidence: 67%

“…Recently, our research group first reported that the essential oil of the leaves of Hyptis martiusii has an antiulcerogenic and antisecretory activity in acute gastric ulcer models [15]. Given that there are no studies regarding the toxicological profile of this species, a repeated-doses (30 days) toxicity study was conducted to evaluate the safety of the oral administration of the essential oil of Hyptis martiusii .…”

Section: Introductionmentioning

confidence: 99%

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Repeated-Doses Toxicity Study of the Essential Oil ofHyptis martiusiiBenth. (Lamiaceae) in Swiss Mice

Caldas

Araújo

Albuquerque

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Hyptis martiusii Benth. (Lamiaceae) is found in abundance in Northeastern Brazil where it is used in traditional medicine to treat gastric disorders. Since there are no studies reporting the toxicity and safety profile of this species, we investigated repeated-doses toxicity of the essential oil of Hyptis martiusii (EOHM). Swiss mice of both sexes were orally treated with EOHM (100 and 500 mg/kg) for 30 days, and biochemical, hematological, and morphological parameters were determined. No toxicity signs or deaths were recorded during the treatment with EOHM. The body weight gain was not affected, but there was an occasional variation in water and food consumption among mice of both sexes treated with both doses. The hematological and biochemical profiles did not show significant differences except for a decrease in the MCV and an increase in albumin, but these variations are within the limits described for the species. The microscopic analysis showed changes in liver, kidneys, lungs, and spleen; however, these changes do not have clinical relevance since they varied among the groups, including the control group. The results indicate that the treatment of repeated-doses with the essential oil of Hyptis martiusii showed low toxicity in mice.

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Section: Discussionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Repeated-Doses Toxicity Study of the Essential Oil ofHyptis martiusiiBenth. (Lamiaceae) in Swiss Mice

Caldas

Araújo

Albuquerque

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…For example, spathulenol was majorly presented in Croton argyrophylloides demonstrating anticancer, immunomodulatory (ZIAEI et al, 2011), antibacterial (ALCÂNTARA et al, 2010, antiinflammatory and antioxidant activity (RAMOS et al, 2013). 1,8-cineol has also presented as a major compound of the essential oil of Hyptis martiusii, presenting gastro-protective activity (CALDAS et al, 2011). The species Croton sonderianus, Croton zehntneri, Croton nepetaefolius and Croton argyrophylloides were also identified where these demonstrate anti-inflammatory and antinociceptive action (AMARAL, 2004;MORAIS et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

Chemical composition, antibacterial and modulatory action of the essential oil of Croton rhamnifolioides leaves Pax and Hoffman

Vidal¹,

Oliveira-Tintino²,

Tintino³

et al. 2016

Biosci. J.

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ABSTRACT:The species Croton rhamnifolioides is a shrub popularly known as "quebra faca", utilized in teas or infusions for the treatment of gastrointestinal disorders as ulcers, gastric discomfort, vomiting and hemorrhagic diarrhea. This work has as its main objective to evaluate the chemical composition of the essential oil of the Croton rhamnifolioides leaves (EOC), antibacterial activity and modulatory activity of antibiotic resistance, against bacterial strains of Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and, and antifungal activity against Candida albicans, Candida krusei and Candida tropicalis. The chemical composition was determined through chromatography with a gas phase coupled with mass spectrometry (CG/MS), whereas antimicrobial activity and modulation were determined by microdilution assay. The chemical composition of the oil revealed 21 compounds, with the major compounds being spathulenol (22.46%) and 1,8-cineol (18.32%). The antimicrobial activity was not significant with MIC>1024 µg/mL, however, was observed a synergistic interference when essential oil associated with the antibiotics aminoglycoside and β-lactam, and the antifungal polyene.

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“…Modulation of antibiotic activity by EOs through gaseous contact is a new approach that should be taken into consideration especially, in the case of respiratory infections. Cidreira-do-mato [62], also known as cidreira-brava [63] ( Hyptis martiusii Benth., Lamiaceae), EO increased the susceptibility to tobramycin of E. coli ATCC 25922 and the EC27 multidrug-resistant surgical wound isolate by 76.5% and 80%, respectively; in addition, it considerably reduced the resistance to gentamicin and amikacin of the EC27 isolate (by 40% and 82.4%, respectively). The main constituents of cidreira-brava EO were bicyclogermacrene (10.6%), trans -caryophyllene (9.2%), caryophyllene oxide (7.4%), 1,8-cineole (7%) and δ-2-carene (6.8%) [64].…”

Section: Essential Oils and Volatile Compounds Modulating Antibiotmentioning

confidence: 99%

Essential Oils and Their Components as Modulators of Antibiotic Activity against Gram-Negative Bacteria

et al. 2016

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Gram-negative bacteria cause infections that are difficult to treat due to the emergence of multidrug resistance. This review summarizes the current status of the studies investigating the capacity of essential oils and their components to modulate antibiotic activity against Gram-negative bacteria. Synergistic interactions are particularly discussed with reference to possible mechanisms by which essential oil constituents interact with antibiotics. Special emphasis is given to essential oils and volatile compounds that inhibit efflux pumps, thus reversing drug resistance in Gram-negative bacteria. In addition, indifference and antagonism between essential oils/volatile compounds and conventional antibiotics have also been reported. Overall, this literature review reveals that essential oils and their purified components enhance the efficacy of antibiotics against Gram-negative bacteria, being promising candidates for the development of new effective formulations against Gram-negative bacteria.

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Antiulcerogenic activity of the essential oil of Hyptis martiusii Benth. (Lamiaceae)

Cited by 43 publications

References 33 publications

Repeated-Doses Toxicity Study of the Essential Oil ofHyptis martiusiiBenth. (Lamiaceae) in Swiss Mice

Repeated-Doses Toxicity Study of the Essential Oil ofHyptis martiusiiBenth. (Lamiaceae) in Swiss Mice

Chemical composition, antibacterial and modulatory action of the essential oil of Croton rhamnifolioides leaves Pax and Hoffman

Essential Oils and Their Components as Modulators of Antibiotic Activity against Gram-Negative Bacteria

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