Evaluation of gamma glutamyl transferase as a marker of cardiovascular risk, in 200 angiographically proven coronary artery disease patients

Bharani, Vani; Ramesh, V.; Rao, Ram Nawal; Tewari, Satyendra

doi:10.1016/j.ihj.2017.03.010

Cited by 9 publications

(12 citation statements)

References 13 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further, a number of studies indicated that serum GGT levels were associated with increased risk of myocardial infarction, HF, and mortality after PCI. [2][3][4][5][6][7][16][17][18][19] However, the mechanism of this association remains unclear. Several possible explanations of this association are lack of strong evidences.…”

Section: Discussionmentioning

confidence: 99%

“…H eart failure (HF) is a worldwide epidemic that is associated with considerable hospitalization and mortality. 1 Recently, several studies have shown that elevated g-glutamyl transferase (GGT) levels are associated with increased risk of coronary artery disease (CAD), [2][3][4][5] mortality, 6,7 and HF. 8,9 Wang et al 8 enrolled 18,353 Finnish men and 19,726 women who were 25-74 years of age and free of HF at baseline to investigate the relation between serum GGT levels and HF incidence.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Moderate Serum γ-Glutamyl Transferase Level Is Beneficial for Heart Failure After Percutaneous Coronary Intervention

Zheng

Wang

You

et al. 2019

Metabolic Syndrome and Related Disorders

View full text Add to dashboard Cite

Objective: Previous studies suggested that elevated serum g-glutamyl transferase (GGT) level is an independent predictor of coronary artery disease (CAD) and heart failure (HF). However, whether serum GGT level has a predictive role for HF after percutaneous coronary intervention (PCI) remains unclear. This study aimed to evaluate the association of GGT with HF after PCI in a Chinese population. Methods: Five thousand six hundred thirty-eight patients were divided into three groups according to GGT tertiles: first tertile (GGT <19.6 U/L; n = 1875), second tertile (GGT ‡19.6-32.9 U/L; n = 1880), and third tertile (GGT ‡32.9 U/L; n = 1883). There were 165 (2.9%) HFs during a long-term follow-up. The average follow-up time was 35.9-22.6 months. Results: The incidence of HF in the first tertile is 62 (3.3%), second tertile is 38 (2.0%), and third tertile is 65 (3.5%). The HF incidence was significantly lower in second tertile compared with that in the first tertile or in the third tertile (both P < 0.05). A U-shaped curve was observed according to quintiles (Q1:3.4%, Q2: 3.0, Q3:1.6%, Q4: 2.9%, Q5: 3.7%, P = 0.042). The multivariate Cox proportional hazards model showed after adjustment of confounders, the association remains significant (P = 0.046). Conclusions: This study indicated that serum GGT concentration was independently associated with HF after PCI. The baseline serum GGT level less than 19.6 or ‡32.9 increases HF risk in CAD patients who underwent PCI.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Moderate Serum γ-Glutamyl Transferase Level Is Beneficial for Heart Failure After Percutaneous Coronary Intervention

Zheng

Wang

You

et al. 2019

Metabolic Syndrome and Related Disorders

View full text Add to dashboard Cite

show abstract

“…This, together with the dosage of serum levels of troponin and serum levels of some cardiomiochemicaly released isozymes (CK-MB, LDH 1 ) allowed us to rule out the possibility of myocardial ischemia, which would have contributed to the increase in serum concentration of GGT 3 , 7 , 8 .…”

Section: Methodsmentioning

confidence: 99%

Gamma-glutamyltransferase, possible novel biomarker in colon diverticulosis: a case-control study

Bălăeţ

Coculescu

Manole

et al. 2018

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

The gamma-glutamyltransferase (GGT) is recognized in medical practice as a useful indicator for the detection of liver lesions, especially those induced by the excessive consumption of alcoholic or cholesterol-associated drinks. The present study, although it includes a very small number of cases diagnosed with colon diverticulosis-diverticulitis associated with polyposis at the same intestinal level, identifies the presence of increased circulating concentrations of this enzyme in the serum. Its serum levels are tracked “dynamically” throughout a year after the diagnosis and start of the therapy. The study calls into question the release of the enzyme from the edge of the enterocytes’ brush-like edge, leading to the pathogenic disturbance of regional redox homeostasis. The hypothesis gives the circulating values of GGT predictive value for cellular oxidative stress, as well as for indirectly expressing the glutathione level in cytosol.

show abstract

“…• family history of CAD 10% [39] Ndrepepa G et al investigated the association between GGT and arterial fibrillation in 5,501 CAD patients. Patients with arterial fibrillation presented elevated serum GGT levels compared to patients with sinus rhythm; 52 U/l versus 34.8 U/l.…”

Section: Ggt and Hypertensionmentioning

confidence: 99%

Gamma-glutamyl transferase and cardiovascular disease risk

Miricescu¹,

Totan²,

Stănescu³

et al. 2020

Ro Med J.

View full text Add to dashboard Cite

Cardiovascular diseases (CVD) represent a major health problem in adult population worldwide. Together with conventional risk factors, gamma-glutamyl transferase (GGT) is involved in the pathogenesis of CVD. The purpose of this review is to provide informations about GGT synthesis, physiological roles and the involvement in the atherosclerotic plaque formation. The results of the most recent clinical studies performed to find an association between GGT serum activity and patients with hypertension and coronary artery disease (CAD) are presented.

show abstract

Evaluation of gamma glutamyl transferase as a marker of cardiovascular risk, in 200 angiographically proven coronary artery disease patients

Cited by 9 publications

References 13 publications

Moderate Serum γ-Glutamyl Transferase Level Is Beneficial for Heart Failure After Percutaneous Coronary Intervention

Moderate Serum γ-Glutamyl Transferase Level Is Beneficial for Heart Failure After Percutaneous Coronary Intervention

Gamma-glutamyltransferase, possible novel biomarker in colon diverticulosis: a case-control study

Gamma-glutamyl transferase and cardiovascular disease risk

Contact Info

Product

Resources

About