Evaluation of gait in Duchenne Muscular Dystrophy: Relation of 3D gait analysis to clinical assessment

Romano, Alberto; Favetta, Martina; Schirinzi, Tommaso; Summa, Susanna; Minosse, Silvia; D’Amico, Adele; Catteruccia, Michela; Petrarca, Maurizio; Castelli, Enrico; Bertini, Enrico; Vasco, Gessica

doi:10.1016/j.nmd.2019.10.007

Cited by 17 publications

(31 citation statements)

References 34 publications

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“…Children with Duchenne dystrophy showed similar ankle behavior. Yet, in that case, even if the mechanism of passive mechanical energy exploitation is similar, the cause is different because it is due to the decline of contractile fiber in muscles and their relative weakness ( Romano et al, 2019 ). In children with Charcot-Marie-Tooth, we observed a reduction of the ankle range of motion, probably linked mainly to both muscular and articular degeneration.…”

Section: Discussionmentioning

confidence: 99%

“…Pelvic anteversion in children with CP could be interpreted as a simplification of the pelvis stabilization in stance phase, hanging on the hamstring muscles, reaching maximum anteversion during the monopodic support gait phase. In children with Duchenne, where the main problem is the weakness and not the deficit of fine motor control, the double bump is present, but it is in phase with the control group, a sort of boost of functional activities ( Romano et al, 2019 ). Children with Charcot-Marie-Tooth present a tendency toward pelvic retroversion.…”

Section: Discussionmentioning

confidence: 99%

“…They can be considered paradigmatic examples corresponding to damage involving the upper motor neuron, the lower motor neuron, and the muscles. CP, CMT and DMD children present complex and heterogeneous gait patterns already described using gait analysis tools ( Salami et al, 2017 ; Wojciechowski et al, 2017 ; Davids et al, 2018 ; Goudriaan et al, 2018 ; Romano et al, 2019 ). To date, there has been no comparative study aimed at defining similarities and differences.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the Gait Biomechanical Constraints in Three Different Type of Neuromotor Damages

Minosse

Favetta

Romano

et al. 2022

Front. Hum. Neurosci.

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Background and ObjectiveAbsolute angle represents the inclination of a body segment relative to a fixed reference in space. This work compares the absolute and relative angles for exploring biomechanical gait constraints.MethodsGait patterns of different neuromotor conditions were analyzed using 3D gait analysis: normal gait (healthy, H), Cerebral Palsy (CP), Charcot Marie Tooth (CMT) and Duchenne Muscular Dystrophy (DMD), representing central and peripheral nervous system and muscular disorders, respectively. Forty-two children underwent gait analysis: 10 children affected by CP, 10 children by CMT, 10 children by DMD and 12 healthy children. The kinematic and kinetic parameters were collected to describe the biomechanical pattern of participants’ lower limbs. The absolute angles of thigh, leg and foot were calculated using the trigonometric relationship of the tangent. For each absolute series, the mean, range, maximum, minimum and initial contact were calculated. Kinematic and kinetic gait data were studied, and the results were compared with the literature.ResultsStatistical analysis of the absolute angles showed how, at the local level, the single segments (thigh, leg and foot) behave differently depending on the pathology. However, if the lower limb is studied globally (sum of the kinematics of the three segments: thigh, leg and foot), a biomechanical constraint emerges.ConclusionEach segment compensates separately for the disease deficit so as to maintain a global biomechanical invariance. Using a model of inter-joint co-variation could improve the interpretation of the clinical gait pattern.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of the Gait Biomechanical Constraints in Three Different Type of Neuromotor Damages

Minosse

Favetta

Romano

et al. 2022

Front. Hum. Neurosci.

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“…For instance, the measurement and quantified metrics of muscle activity during crawling can help to determine whether patients suffer from muscle fatigue and overtraining during quadrupedal training, and kinematic and locomotor metrics can be used to evaluate the effectiveness of crawling intervention on motor function improvement in the long term. As we mentioned in the introduction, objective assessment of motor function during walking can be conducted by gait analysis, which has been widely used in clinics and typically provides quantified metrics of kinematic and muscle activities (79)(80)(81)(82)(83). For those infants without walking ability, movement abnormalities are usually assessed by scores obtained on screening tests or visual analysis of their movement quality (84)(85)(86), which are relatively subjective and with poor specificity.…”

Section: Crawling Measurement As Early Identification Of Motor Function In Early Infancymentioning

confidence: 99%

Measurement and Analysis of Human Infant Crawling for Rehabilitation: A Narrative Review

Xiong

Liu

et al. 2021

Front. Neurol.

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When a child shows signs of potential motor developmental disorders, early diagnosis of central nervous system (CNS) impairment is beneficial. Known as the first CNS-controlled mobility for most of infants, mobility during crawling usually has been used in clinical assessments to identify motor development disorders. The current clinical scales of motor development during crawling stage are relatively subjective. Objective and quantitative measures of infant crawling afford the possibilities to identify those infants who might benefit from early intervention, as well as the evaluation of intervention progress. Thus, increasing researchers have explored objective measurements of infant crawling in typical and atypical developing infants. However, there is a lack of comprehensive review on infant-crawling measurement and analysis toward bridging the gap between research crawling analysis and potential clinical applications. In this narrative review, we provide a practical overview of the most relevant measurements in human infant crawling, including acquisition techniques, data processing methods, features extraction, and the potential value in objective assessment of motor function in infancy; meanwhile, the possibilities to develop crawling training as early intervention to promote the locomotor function for infants with locomotor delays are also discussed.

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“…Motion analysis techniques have been used in the medical field to analyze disease-specific gait patterns to determine the causal factors of pathological gait, monitor responses to medical interventions, plan medical interventions, and classify diseases. 6 7 8 9 In the field of sports medicine, motion analysis has been used to monitor the angle and angular velocity of an athlete’s limb motion to prevent sports injury or enhance performance. 10 11 12 13 With the development of sensors and Bluetooth devices, obtaining human kinematic data has become more convenient, such that patients can provide their movement data, even data obtained outside the hospital, to physicians in a less cumbersome way.…”

Section: Introductionmentioning

confidence: 99%

Real-Time Exercise Feedback through a Convolutional Neural Network: A Machine Learning-Based Motion-Detecting Mobile Exercise Coaching Application

2022

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Purpose Mobile applications are widely used in the healthcare market. This study aimed to determine whether exercise using a machine learning-based motion-detecting mobile exercise coaching application (MDMECA) is superior to video streaming-based exercise for improving quality of life and decreasing lower back pain. Materials and Methods The same 14-day daily workout program consisting of five exercises was performed by 104 participants using the MDMECA and another 72 participants using video streaming. The Medical Outcomes Study Short Form 36-Item Health Survey (SF-36) and lower back pain scores were assess as pre- and post-workout measurements. Scores for the treatment-satisfaction subscale of the visual analog scale (TS-VAS), intention to use a disease-oriented exercise program, intention to recommend the program to others, and available expenses for a disease-oriented exercise program were determined after the workout. Results The MDMECA group showed a higher increase in SF-36 score (MDMECA, 9.10; control, 1.09; p <0.01) and a greater reduction in lower back pain score (MDMECA, -0.96; control, -0.26; p <0.01). Scores for TS-VAS, intention to use a disease-oriented exercise program, and intention to recommend the program to others were all higher ( p <0.01) in the MDMECA group. However, the available expenses for a disease-oriented program were not significantly different between the two groups. Conclusion The MDMECA is more effective than video streaming-based exercise in increasing exercise adherence, improving QoL, and reducing lower back pain. MDMECAs could be promising tools of use to achieve better medical outcomes and higher treatment satisfaction.

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Evaluation of gait in Duchenne Muscular Dystrophy: Relation of 3D gait analysis to clinical assessment

Cited by 17 publications

References 34 publications

Comparison of the Gait Biomechanical Constraints in Three Different Type of Neuromotor Damages

Comparison of the Gait Biomechanical Constraints in Three Different Type of Neuromotor Damages

Measurement and Analysis of Human Infant Crawling for Rehabilitation: A Narrative Review

Real-Time Exercise Feedback through a Convolutional Neural Network: A Machine Learning-Based Motion-Detecting Mobile Exercise Coaching Application

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