Evaluation of functional properties and fibroblast growth on squashy cellular scaffolds

Kruk, Aleksandra; Gadomska‐Gajadhur, Agnieszka; Dulnik, Judyta; Rykaczewska, I.; Ruśkowski, Paweł; Sebai, Agnieszka; Synoradzki, Ludwik

doi:10.14314/polimery.2018.4.3

Cited by 4 publications

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“…Very good mechanical properties of scaffolds are a feature that distinguishes the method of dry phase inversion from others. Similar techniques of inversion phase method, for example, freeze extraction allow to obtain scaffold with low mechanical properties …”

Section: Resultsmentioning

confidence: 99%

Influence of liquid pore precursors on morphology and mechanical properties of 3D scaffolds obtained by dry inversion phase method

et al. 2018

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Polyester 3D scaffolds were obtained by dry inversion phase method. The influence of a polymer and liquid pore precursor type on the 3D scaffolds morphology, porosity and mechanical properties was tested. Polymers and precursors forming a porous structure were identified. It was found that 3D scaffolds having the most preferable structure for cell cultures were obtained from polylactide with the addition of n-butanol as the liquid pore precursor. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res B Part B, 2018.

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Section: Resultsmentioning

confidence: 99%

Influence of liquid pore precursors on morphology and mechanical properties of 3D scaffolds obtained by dry inversion phase method

et al. 2018

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“…Biodegradable polymers are used to produce dressing materials (including hydrogel ones , ), resorbable surgical threads, and bone implants, as well as connectors and screws for bonding broken bones . Polymeric materials are also used for cell scaffolds to rebuild damaged tissues (e.g., cartilage, bone, , nerve, and epithelial tissue).…”

Section: Introductionmentioning

confidence: 99%

Optimization of Poly(glycerol sebacate) Synthesis for Biomedical Purposes with the Design of Experiments

Gadomska‐Gajadhur

Wrzecionek

Matyszczak

et al. 2018

Org. Process Res. Dev.

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Efficient, original synthesis of poly(glycerol sebacate) (PGS) via polycondensation of glycerine and sebacic acid was achieved. The process was successfully optimized by using the Box–Behnken design. PGS was obtained with a high conversion of the carboxylic group (89%) and a very high degree of esterification (∼82%), containing no catalysts residues. A method was developed for purification of prepolymer PGS. Because biocompatible substrates are used, this method for obtaining the polymer can be used in medical and pharmaceutical applications.

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Biomineralization of poly‐l‐lactide spongy bone scaffolds obtained by freeze‐extraction method

et al. 2019

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Implants in the form of polymer scaffolds are commonly used to regenerate bone tissue after traumas or tooth extractions. However, few implant formation methods enable building polymer scaffolds allowing to reconstruct larger bone losses without immune response. Spacious, porous poly‐l‐lactide implants with considerable volume were obtained using the phase inversion method with the freeze‐extraction variant. The calcium phosphate (CaP) coating was deposited on implant surfaces with the biomimetic method to improve the implant's osteoconductivity. The substitues morphology was characterized—porosity, size and shape of pores; mechanical properties, mass absorbability of implants before and after mineralization. The characteristics were provided with scanning electron microscopy (SEM), static compression test and hydrostatic weighing, respectively. The presence of CaPs in the entire volume of the implant was confirmed with SEM and infrared spectroscopy with Fourier transform (FTIR). The biocompatibility of scaffolds was confirmed with in vitro quantitative test and microscopic observations. The obtained results show that the implants can be used in tissue engineering as a vehicle of platelet‐rich plasma to regenerate critical spongy bone losses.

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Evaluation of functional properties and fibroblast growth on squashy cellular scaffolds

Cited by 4 publications

References 3 publications

Influence of liquid pore precursors on morphology and mechanical properties of 3D scaffolds obtained by dry inversion phase method

Influence of liquid pore precursors on morphology and mechanical properties of 3D scaffolds obtained by dry inversion phase method

Optimization of Poly(glycerol sebacate) Synthesis for Biomedical Purposes with the Design of Experiments

Biomineralization of poly‐l‐lactide spongy bone scaffolds obtained by freeze‐extraction method

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