Evaluation of functional capacity and muscle metabolism in individuals with peripheral arterial disease with and without diabetes

Geisel, Patrícia Paulino; Monteiro, Débora Pantuso; Nascimento, Isabella de Oliveira

doi:10.1016/j.jvs.2021.08.082

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…It was also reported in the literature that the BOLD response is correlated with the measurements of mitochondrial oxidative capacity in calf muscles of PAD patients, indicating that the BOLD parameters have the potential to measure the physiological process of muscle movement. 30,31 The association of perfusion measurements and walking performance indicated that BOLD imaging might be able to evaluate the microvascular function and severity of PAD noninvasively.…”

Section: Discussionmentioning

confidence: 99%

Blood Oxygen Level‐Dependent MR Imaging of Lower Extremities in Peripheral Artery Disease and Its Correlation With Walking Performance

Liu

Shao

et al. 2023

Magnetic Resonance Imaging

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BackgroundA noninvasive and reliable approach to quantitatively measure muscle perfusion of lower extremity is needed to aid the diagnosis and treatment of peripheral artery disease (PAD).PurposeTo verify the reproductivity of using blood oxygen level‐dependent (BOLD) imaging to evaluate perfusion in lower extremities, and explore its correlation with walking performance in patients with PAD.Study TypeProspective observational study.SubjectsSeventeen patients with lower extremity PAD (mean age: 67 ± 6 years, 15 males) and eight older adults (controls).Field Strength/SequenceDynamic multi‐echo gradient echo T2* weighted imaging at 3T.AssessmentPerfusion was analyzed in regions of interest according to muscle groups. Perfusion parameters were measured, such as minimum ischemia value (MIV), time to peak (TTP), and gradient during reactive hyperemia (Grad) by two independent users. Walking performance experiments including short physical performance battery (SPPB) and 6‐minute walk were tested in patients.Statistical TestsBOLD parameters were compared using Mann–Whitney U test and Kruskal–Wallis test. Relations between parameters and walking performance were assessed by Mann–Whitney U test and Spearman's correlation coefficient.ResultsGood to perfect agreement was demonstrated for all perfusion parameters of interuser reproducibility, and the interscan reproducibility of MIV, TTP, and Grad was good. The TTP of the patients was longer than that of the controls (87.85 ± 38.85 s vs. 36.54 ± 7.27 s), while the Grad of patients was smaller (0.16 ± 0.12 msec/s vs. 0.24 ± 0.11 msec/s). Among PAD patients, the MIV was significantly lower in the low SPPB subgroup (score 6–8) than in the high SPPB group (score 9–12), and the TTP was negatively correlated with 6‐minute walk distance (ρ = −0.549).Data ConclusionBOLD imaging method had overall good reproducibility for the perfusion assessment of calf muscles. The perfusion parameters were different between PAD patients and controls, and were correlated with lower extremity function.Evidence Level2Technical EfficacyStage 2

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Section: Discussionmentioning

confidence: 99%

Blood Oxygen Level‐Dependent MR Imaging of Lower Extremities in Peripheral Artery Disease and Its Correlation With Walking Performance

Liu

Shao

et al. 2023

Magnetic Resonance Imaging

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“…Each point will be calculated as the average during the 15 s before each time point. Additionally, the time to reach the minimum calf StO 2 value and the area under the curve for the deoxygenation period during exercise will be assessed 59 60. The reoxygenation time in the supine position (the time from the end of the test until calf StO 2 returns to baseline) will also be recorded 59 60.…”

Section: Methodsmentioning

confidence: 99%

“…Additionally, the time to reach the minimum calf StO 2 value and the area under the curve for the deoxygenation period during exercise will be assessed 59 60. The reoxygenation time in the supine position (the time from the end of the test until calf StO 2 returns to baseline) will also be recorded 59 60. The signal will be recorded at 10 Hz with a differential pathlength factor of 6.0.…”

Section: Methodsmentioning

confidence: 99%

Short-duration aerobic high-intensity intervals versus moderate exercise training intensity in patients with peripheral artery disease: study protocol for a randomised controlled trial (the Angiof-HIIT Study)

Lanzi,

Pousaz,

Fresa

et al. 2024

BMJ Open

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IntroductionSupervised exercise training is among the first-line therapies for patients with peripheral artery disease (PAD). Current recommendations for exercise include guidance focusing on claudication pain, programme and session duration, and frequency. However, no guidance is offered regarding exercise training intensity. This study aims to compare the effects of 12-week-long supervised walking exercise training (high-intensity interval training (HIIT) vs moderate-intensity exercise (MOD)) in patients with chronic symptomatic PAD.Methods and analysisThis study is a monocentric, interventional, non-blinded randomised controlled trial. 60 patients (30 in each group) will be randomly allocated (by using the random permuted blocks) to 12 weeks (three times a week) of HIIT or MOD. For HIIT, exercise sessions will consist of alternating brief high-intensity (≥85% of the peak heart rate (HRpeak)) periods (≤60 s) of work with periods of passive rest. Patients will be asked to complete 1 and then 2 sets of 5–7 (progressing to 10–15×60 s) walking intervals. For the MOD group, exercise training sessions will consist of an alternation of periods of work performed at moderate intensity (≤76% HRpeak) and periods of passive rest. Interventions will be matched by training load. The primary outcome will be the maximal walking distance. Secondary outcomes will include functional performance, functional capacity, heath-related quality of life, self-perceived walking abilities, physical activity and haemodynamic parameters.Ethics and disseminationThe Angiof-HIIT Study was approved by the Human Research Ethics Committee of the Canton de Vaud (study number: 2022-01752). Written consent is mandatory prior to enrolment and randomisation. The results will be disseminated via national and international scientific meetings, scientific peer-reviewed journals and social media.Trial registration numberNCT05612945.

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Welche peripheren Faktoren beeinflussen Gehfähigkeit von Personen mit PAD?

2022

Gefäßmedizin Scan - Zeitschrift für Angiologie, Gefäßchirurgie,

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Wissenschaftler*innen der Universität von Minas Gerais untersuchten die Muskelstoffwechsel- und Gefäßfunktionsvariablen bei Personen mit peripherer arterieller Verschlusskrankheit (PAD) mittels Nahinfrarotspektroskopie und ihre möglichen Assoziationen mit der funktionellen Kapazität. Darüber hinaus suchten sie nach Unterschieden dieser Variablen zwischen Personen mit PAD und verifiziertem Diabetes mellitus (DM) und solche mit PAD ohne DM.

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Evaluation of functional capacity and muscle metabolism in individuals with peripheral arterial disease with and without diabetes

Cited by 3 publications

References 33 publications

Blood Oxygen Level‐Dependent MR Imaging of Lower Extremities in Peripheral Artery Disease and Its Correlation With Walking Performance

Blood Oxygen Level‐Dependent MR Imaging of Lower Extremities in Peripheral Artery Disease and Its Correlation With Walking Performance

Short-duration aerobic high-intensity intervals versus moderate exercise training intensity in patients with peripheral artery disease: study protocol for a randomised controlled trial (the Angiof-HIIT Study)

Welche peripheren Faktoren beeinflussen Gehfähigkeit von Personen mit PAD?

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