Evaluation of Free Radical Scavenging and Antiulcer Potential of Methanolic Extract of Benincasa hispida Seeds

Gill, N.S.; Dhiman, Kunal; Bajwa, Jasveen; Sood, Shailja; Sharma, PD; Singh, Balraj; Bali, M.

doi:10.3923/rjmp.2011.596.604

Cited by 15 publications

(2 citation statements)

References 12 publications

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“…Ulcer was induced by pylorus ligation, indomethacin and water immersion stress in albino rats (Gill et al, 2011). The plant extract showed gastroprotective activity in a dose-dependent manner via significant decrease in ulcer score, ulcer index, total acidity and gastric volume in plant treated groups.…”

Section: Benincasa Hispidamentioning

confidence: 97%

Medicinal plants with gastroprotective potential

Majeed¹,

Khaliq²,

Aslam³

et al. 2015

Bangladesh J Pharmacol

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<p class="Abstract">Peptic ulcer disease (PUD) is a main source of morbidity and mortality worldwide. It is characterized by erosions in mucosal linings of stomach and duodenum. Non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori are mainly responsible for peptic ulcer disease. Histamine receptor blockers and proton pump inhibitors are most prominent therapies in the treatment of peptic ulcer. However, severe adverse effects of NSAIDs have been reported. Therefore, focus is now diverted towards herbal formulations of medicinal plants for the treatment of ulcer. Plants contain different phytoconstituents which are responsible for increasing defensive mechanisms of body against peptic ulcer. The current review focuses on the commonly used gastroprotective plants as antiulcer agents.</p><p> </p>

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Section: Benincasa Hispidamentioning

confidence: 97%

Medicinal plants with gastroprotective potential

Majeed¹,

Khaliq²,

Aslam³

et al. 2015

Bangladesh J Pharmacol

View full text Add to dashboard Cite

show abstract

“…Total protein and free amino acids have concentrations of 216.400 and 92.549 mg/100 g fresh weight, respectively. 23 It exhibits a wide range of biological activities, such as anti-inflammatory, antipyretic, 24 neuromodulatory, 25 anti-aging, 26 immunomodulatory, hepatoprotective, antidiabetic, 27 anti-obesity, 28 anti-ulcer, 29 anti-oxidant, 30 angiotensin-converting enzyme inhibitory, 31 diuretic, nephroprotective, 32 5α-reductase inhibitory/anti-androgenic, anti-angiogenesis 33 and antimicrobial. 34 It also inhibits the mRNA expression level of monocyte chemoattractant protein-1 (MCP-1), interleukin-8 (IL-8), and ed NF-κB activation by blocking the phosphorylation and degradation of its inhibitory protein, IκB-α in human.…”

Section: Introductionmentioning

confidence: 99%