Evaluation of Free Radical Scavenging Activity of Pandanus odoratissimus

Londonkar, Ramesh L; Kamble, Abhaykumar

doi:10.3923/ijp.2009.377.380

Cited by 23 publications

(20 citation statements)

References 5 publications

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“…Between two extracts, ethanol extract shows maximum activity when compared to aqueous extract. 10,11 . The role of vasopressin as the principal factor regulating renal water handling is supported by experience with ADH receptor antagonists.…”

Section: Resultsmentioning

confidence: 99%

Untitled

2012

IJPSR

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The extracts of the prop roots of Pandanus fascicularis Lam (Family: Pandanaceae) is claimed as an antidiuretic by some traditional practitioners. However, the validity of this claim has not been scientifically proven or refuted. The aim of this study was to evaluate the antidiuretic potential of ethanol and aqueous extracts of prop roots of P. fascicularis in rats following oral administration. Ethanol and aqueous extracts were prepared from P. facicularis by percolation and cold maturation, respectively. Furosemide was used as a diuretic agent to induce diuresis. Vasopressin (ADH) was used as a standard. The results demonstrated both the ethanol and aqueous extracts of P. facicularis and ADH significantly impaired the total urine output. However, antidiuretic potential of ethanolic extract was similar to that of ADH. The extracts caused a significant decrease in natriuresis and kaliuresis. From this study, we can conclude that ethanol extract of prop roots of Pandanus fascicularis has beneficial effects on anti diuretic activity. It has the potential to impart therapeutic effect in diuretic.

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Section: Resultsmentioning

confidence: 99%

Untitled

2012

IJPSR

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“…The methanolic extract of the leaf is said to have moderate antioxidant activity because of its high phenolic content. Other constituents present in the methanolic leaf extract are steroids, saponins, terpinoids, glycosides, tannins and flavonoids (Londonkar et al, 2009). To the best of our knowledge, no studies on the Pandanus odoratissimus in the central nervous system have been reported.…”

Section: Introductionmentioning

confidence: 95%

Potential of Pandanus odoratissimus as a CNS depressant in Swiss albino mice

Raju¹,

Subbaiah²,

Reddy³

et al. 2011

Braz. J. Pharm. Sci.

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In this study, several neuropharmacological effects of methanolic leaf extract of Pandanus odoratissimus (PO) (family; Pandanaceae) were studied in albino mice using various experimental models. The effect of PO on the CNS was studied by using different neuropharmacological paradigms including spontaneous motor activity, rota-rod performance and potentiation of Pentobarbital sodium sleeping time in albino mice. Preliminary phytochemical evaluation and acute toxicity studies were also carried out where LD 50 >2000 mg/kg was considered non-toxic through acute exposure in rats by the oral route. The methanolic leaf extract (50,100 and 200 mg/kg i. p.) produced a reduction in spontaneous motor activity, motor coordination and prolonged Pentobarbital sodium sleeping time. Preliminary qualitative chemical studies indicated the presence of steroids, saponins, terpinoids, glycosides, tannins, flavonoids and phenolics in the extract. These observations suggest that the leaf of Pandanus odoratissimus contains some active principles which possess potential CNS-depressant action Uniterms: Pandanus odoratissimus/pharmacognosy. CNS-depressant action/experimental study. Spontaneous motor activity. Rota-rod performance. Sodium pentobarbital/potentiation of sleeping time.Estudaram-se alguns efeitos neurofarmacológicos do extrato metanólico de Pandanus odoratissimus (PO) (família Pandanaceae) em camundongos albinos, usando vários modelos experimentais. O efeito do PO no SNC foi estudado por meio de diferentes paradigmas neurofarmacológicos, como atividade motora espontânea, desempenho na haste rotatória e a potenciação do tempo de sono em camundongos albinos pelo pentobarbital sódico. A avaliação fitoquímica preliminar e os estudos de toxicidade aguda foram realizados e a DL 50 >2000 mg/kg é considerada não tóxica, por meio da exposição aguda, por via oral, em ratos. O extrato metanólico de folha (50,100 e 200 mg/kg i. p.) produziu redução da atividade motora espontânea, da coordenação motora e tempo prolongado de sono pelo pentobarbital sódico. Estudos químicos qualitativos preliminares indicaram a presença de esteróide, saponinas, terpenóides, glicosídios, taninos, flavonóides e fenólicos no extrato. As observações sugerem que a folha de Pandanus odoratissimus contém alguns princípios ativos com atividade potencial como depressores do SNC. Unitermos:Pandanus odoratissimus/farmacognosia. Ação depressor do SNC/estudo experimental. Atividade motora espontânea. Desempenho na haste rotatória. Pentobarbital sódico/potenciação no tempo de sono.

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“…P. odoratissimus L. (whole plant) exhibit significant antitumor and antioxidant activities [13]; and its leaves possess potential CNS-depressant action [14] as well as anti-inflammatory activity [15]. Moreover, the leaves are reported to have natural antioxidant properties [16,17] and moderate activity against gram-positive bacteria [15].…”

Section: Introductionmentioning

confidence: 99%