Evaluation of Fertility and Embryo Implantation in Rats After the Oral Administration of Salvia officinalis (Sage) Extract

AbdRabou, Mervat Ahmed; Alhumaidi-Alotaibi, Mashael; Elnaga, Nehal A. Abu; Al-Otaibi, Aljohara M.

doi:10.4067/s0717-95022022000501404

Cited by 1 publication

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References 27 publications

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“…Equally, tea prepared from Salvia species has been defined by Grieve (in 1980) as a “highly serviceable stimulant tonic in debility of the nervous system” 13 – 15 . Also, Salvia species would relieve the symptoms of premenstrual syndrome and have an estrogenic effect as a hormonal regulator working on the female urogenital area 16 . Among Salvia species, Salvia lavandulifolia is the most commonly investigated herb in terms of pharmacology, ethnobotany, and biochemical composition 13 , 17 , 18 .…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and antimicrobial effects of essential oils from two salvia species with in vitro and in silico analysis targeting 1AJ6 and 1R4U proteins

Maache,

Zbadi,

Ghouizi

et al. 2023

Sci Rep

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The Middle Atlas is a Moroccan territory that serves as an abode to plants with incredible biodiversity, of which aromatic and medicinal plants that have been of folkloric use are a significant component. However, their effective utilization in modern medicine requires the characterization of their phytochemicals to facilitate their entry into drug discovery pipelines. Hence, this study aimed to characterize and investigate the antioxidant activity and antimicrobial effects of the essential oils (EOs) of Salvia lavandulifolia subsp. mesatlantica and Salvia officinalis L. by use of in vitro and in silico assays. Ten phytochemicals were identified in the EOs of S. lavandulifolia, while twenty phytochemicals were identified in S. officinalis. Camphor was the most abundant compound in both species, comprising 26.70% and 39.24% of the EOs of S. lavandulifolia and S. officinalis, respectively. The EOs of both plants exhibited significant DPPH free radical scavenging activity, with S. lavandulifolia and S. officinalis showing estimated scavenging rates of 92.97% and 75.20%, respectively. In terms of Ferric Reducing Antioxidant Power (FRAP), S. officinalis demonstrated a higher value (72.08%) compared to that of S. lavandulifolia (64.61%). Evaluation of the antimicrobial effects of the EOs of S. officinalis and S. lavandulifolia against microorganisms revealed bactericidal activities against Proteus mirabilis and Bacillus subtilis at low concentrations. It showed bactericidal activities against Staphylococcus aureus and Candida albicans at a relatively higher concentration. Molecular docking of antioxidant and antimicrobial proteins offers significant insights into ligand–protein interactions, facilitating the development of innovative therapeutics from the current study. Ultimately, this study identified the phytochemical composition of S. lavandulifolia and S. officinalis and highlighted their potential for therapeutic discovery.

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Section: Introductionmentioning

confidence: 99%

Antioxidant and antimicrobial effects of essential oils from two salvia species with in vitro and in silico analysis targeting 1AJ6 and 1R4U proteins

Maache,

Zbadi,

Ghouizi

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

Evaluation of Fertility and Embryo Implantation in Rats After the Oral Administration of Salvia officinalis (Sage) Extract

Abstract: Evaluation of fertility and embryo implantation in rats after the oral administration of Salvia officinalis (sage) extract.

Cited by 1 publication

References 27 publications

Antioxidant and antimicrobial effects of essential oils from two salvia species with in vitro and in silico analysis targeting 1AJ6 and 1R4U proteins

Antioxidant and antimicrobial effects of essential oils from two salvia species with in vitro and in silico analysis targeting 1AJ6 and 1R4U proteins

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