Evaluation of excipient potentials of Irvingia wombolu fats and Moringa oil in rifampicin-loaded lipospheres: in vitro-in vivo characterisation

Onyishi, Ikechukwu V.; Chime, Salome Amarachi; Attama, AA

doi:10.1016/s1773-2247(14)50081-0

Cited by 3 publications

(11 citation statements)

References 14 publications

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“…Ozioko; a consultant taxonomist with the International Center for Ethnomedicine and Drug Development (InterCEDD) Nsukka; Ni¬geria and the voucher specimen has been deposited in the herbarium of the Department of Pharmacognosy and Environmental Medicines; University of Nigeria; Nsukka. The shells of the seeds were removed manually and the seeds were milled with a blender (Moulinex Pika-lica) and extracted in a soxhlet extractor using 95 % ethanol [12,21]. The ethanol was allowed to completely evaporate at room temperature.…”

Section: Extraction and Purification Of Fatsmentioning

confidence: 99%

“…Irvingia wombolu kernels (popularly called "Ado" by the Igbos' Nigeria) were also purchased from Nsukka market; Enugu State; Nigeria in the month of June; 2012 from Orba Market; Nsukka; Nigeria and authenticated. The seeds were milled with a hammer mill (500# grinder; China) and extracted in a soxhlet extractor using n-hexane [12,21]. The n-hexane was allowed to completely evaporate at room temperature.…”

Section: Extraction and Purification Of Fatsmentioning

confidence: 99%

“…The extracted fat was successively depolymerised using boiling water and ethylacetate. Both fats extracts were further purified by passing them through a column of activated charcoal and bentonite (2:1) at 100 °C at a ratio of 10 g of fat and 1g of the column material [12]. The fats were stored in a refrigerator until used.…”

Section: Extraction and Purification Of Fatsmentioning

confidence: 99%

“…However; the use of structured lipid matrices in various novel drug delivery systems such as lipospheres could be employed in order to circumvent some of these limitations. Researchers have used this novel technology to increase the overall efficacy while minimizing toxicity of gentamicin [1,[7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…The use of plant-derived lipids in drug delivery is generally preferred to lipids from animals due to the fact that lipids from animals have the possibility of increasing the blood serum cholesterol [12]. Moringa oleifera Linn.…”

Section: Introductionmentioning

confidence: 99%

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Application of Molecularly Structured Ben Oil in Gentamicin Entrapped Lipospheres

Chime

Onyishi

Eze

2019

JPT

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Objective: To formulate extended release gentamicin-entrapped lipospheres using natural lipids from Irvingia wombolu (IWF) and Moringa oleifera seed (MO) popularly known as Ben oil. Methods: Different lipid combinations including IWF and Phospholipon 90H (P90H) and IWF and MO were employed in the formulation of lipospheres. The formulations were analysed for particle size, encapsulation efficiency (EE), pH stability and antimicrobial studies amongst other tests. Also the in vitro release properties were studied in Phosphate buffer pH 7.2. Results: High EE of up to 90 % were obtained for the various LM combinations. The pH was stable over 30 days and the formulations showed about 93 % release of gentamicin at 12 h. Lipospheres formulated with MO matrices showed synergism in the microbial inhibition than other formulations. Conclusion: Natural lipids from Irvingia wombolu and Moringa oleifera seed could be used in formulating oral extended release gentamicin lipospheres.

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Section: Extraction and Purification Of Fatsmentioning

confidence: 99%

Section: Extraction and Purification Of Fatsmentioning

confidence: 99%

Section: Extraction and Purification Of Fatsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Application of Molecularly Structured Ben Oil in Gentamicin Entrapped Lipospheres

Chime

Onyishi

Eze

2019

JPT

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PEGylated aceclofenac solid lipid microparticles homolipid-based solidified reverse micellar solutions for drug delivery

Ugwu

Oraeluno

Eze

et al. 2022

Heliyon

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Enhanced anti-inflammatory and ulcerogenicity of Ibuprofen microsphere formulations using Irvingia wombolu fat (IRW) and moringa oil (MO) as co-lipids

Gugu

Agu

Uronnachi

et al. 2023

BMC Complement Med Ther

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Ibuprofen is a member of the propionic acid class of nonsteroidal anti-inflammatory drugs (NSAIDs) with anti-inflammatory, analgesic, and antipyretic activities used to relieve a variety of pains. The objective of this study was to formulate, characterize and evaluate the in vitro and in vivo properties of ibuprofen formulated as solid lipid microspheres (SLMs) for enhanced delivery. The mixtures of Irvingia wombolu fat (IRW) and moringa oil (MO) each with Phospholipon® 90G (PL90G) at the ratio of 2:1 w/w were prepared by fusion, characterized and used to prepare SLMs. The SLMS were thereafter evaluated using the following parameters: particle size and morphology, stability, and encapsulation efficiency EE (%). In vitro release was carried out in phosphate buffer (pH 7.4). The ibuprofen based SLMs were also evaluated for anti-inflammatory and anti-ulcer effects using animal models. The pH showed significant increase after two months of formulation with a maximum value of 6.4 while the EE obtained were 95.6, 89.4 and 61.6% for SLMs formulated with lipid matrix of Phospholipon® 90G (1% and 2%), and MO (1%) respectively. The in vitro release showed maximum release of 87.8 and 98.97% of the two different lipid-based formulations while anti-inflammatory effect was up to 89.90% after 5 h of inducing inflammation. The SLMs did not show any lesion thus conferring gastroprotection on the formulations. The SLMs exhibited good anti-inflammatory property with gastroprotective action.

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Evaluation of excipient potentials of Irvingia wombolu fats and Moringa oil in rifampicin-loaded lipospheres: in vitro-in vivo characterisation

Cited by 3 publications

References 14 publications

Application of Molecularly Structured Ben Oil in Gentamicin Entrapped Lipospheres

Application of Molecularly Structured Ben Oil in Gentamicin Entrapped Lipospheres

PEGylated aceclofenac solid lipid microparticles homolipid-based solidified reverse micellar solutions for drug delivery

Enhanced anti-inflammatory and ulcerogenicity of Ibuprofen microsphere formulations using Irvingia wombolu fat (IRW) and moringa oil (MO) as co-lipids

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