Evaluation of ethanolic extract of Cucumis melo L. for inflammation and hyperplasia of prostate

Ittiyavirah, Sibi P.; Cheriyan, Silby

doi:10.4103/2231-0738.139403

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…C. melo extract showed anti-cancer activity, this result is in accordance with previous study showing that C. melo reduced hyperplasia of the prostate and induces apoptotis [37]. A common component in melons, 3methylthiopropionic acid ethyl ester (MTPE), was first identified as a volatile constituent of C. melo [38].…”

Section: Discussionsupporting

confidence: 89%

Phytochemical, Free Radical Scavenging and Cytotoxic Assay of Cucumis Melo L. Extract and β-Carotene

Widowati¹,

Widyanto²,

Laksmitawati³

et al. 2015

JOAAT

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 Abstract-Deaths from cancer worldwide are estimated to continue rising. Free radicals are toxic to cellular components. It is known that they cause DNA damage, contribute to DNA instability and mutation, thus favor carcinogenesis. This research was conducted to determine the activity of Cucumis melo extract and β-carotene in antioxidative and cytotoxic potencies. The research was done by examining the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity assay. The cytotoxic potency was determined by the MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay on HeLa, HepG2 and NIH3T3 cell lines. β-carotene exhibited more active DPPH free radical scavenging activity compared with C. melo extract. C. melo extract showed more active anti-cancer both in HeLa (IC 50 : 23.649 µg/mL) and HepG2 (IC 50 : 110.403 µg/mL) cancer cells. C. melo extract (IC 50 : 16,670.404 µg/mL) and β-carotene (IC 50 : 50,645.994 µg/mL) had low cytotoxicity in NIH3T3 fibroblast. C. melo extract has lower antioxidant activity, but higher cytotoxic potency compared with β-carotene.

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Section: Discussionsupporting

confidence: 89%

Phytochemical, Free Radical Scavenging and Cytotoxic Assay of Cucumis Melo L. Extract and β-Carotene

Widowati¹,

Widyanto²,

Laksmitawati³

et al. 2015

JOAAT

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“…This shows that melon fruit extract has much better anti-cancer properties compared to soursop juice. In other studies it has also been proven that melons have the potential as anti-cancer in PC3 prostate cancer cells and RCM-1 colon cancer cells, because they contain MTPE which functions as an anticancer 15,17 .…”

Section: Discussionmentioning

confidence: 93%

“…Based on U.S National Cancer Institute (NCI) a crude extract is considered to have cytotoxicity activity in vitro if it has an IC 50 value of less than 20 μg/mL and less than 4 μg/mL for pure compounds 14 . However, another study said that have active anticancer properties with an IC 50 value of 23,649 μg/ mL in HeLa cells, 110,403 μg/mL in HepG2 cells, and anti-proliferative with IC 50 values of 220 μg/mL in PC3 prostate cancer cells 15,10 .…”

Section: Discussionmentioning

confidence: 99%

Free radical scavenging and cytotoxic assay of soursop fruit juice (Annona muricata Linn.) on cervical cancer cell lines (HeLa)

Widyanto

Putri

Kurniasari

et al. 2020

IJND

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ABSTRAKLatar belakang: Kanker serviks merupakan penyakit yang menduduki posisi kedua penyebab kematian pada wanita. Berbagai terapi pendukung mulai dikembangkan, seperti melalui bahan makanan yang dipercaya memiliki efek anti-kanker. Buah sirsak disebut memiliki kandungan fitokimia seperti Annonaceous acetogenin, flavonoid dan fenol yang bermanfaat sebagai anti-kanker. Tujuan: Penelitian ini dilakukan untuk mengetahui potensi anti-oksidan dan sitotoksisitas dari sari buah sirsak pada sel HeLa secara in vitro. Metode: Penelitian ini dilakukan dengan membuat sari buah sirsak dengan cara diblender kemudian dikeringkan dengan metode freeze-drying, yang kemudian dilanjutkan dengan uji 2,2-diphenyl-1-picrylhydrazyl (DPPH) untuk mengetahui potensi penghambatan radikal bebas, dan potensi sitotoksisitas melalui uji MTT (3-(4,5-dimetiltiazol-2-il)-2,5-difenitetrazolium bromide) assay pada sel kanker serviks HeLa. Hasil: Hasil uji aktivitas anti-oksidan menunjukkan persamaan regresi linier (y=0,0149x – 2,8812) dan nilai perhitungan IC50 sari buah sirsak sebesar 3549 μg/mL dan hasil uji sitotoksisitas menunjukkan persamaan regresi linier (y=0,0197x + 0,3101) dan nilai perhitungan IC50 sari buah sirsak pada sel HeLa sebesar 2522,33 μg/mL.Kesimpulan: Sari buah sirsak memiliki aktivitas anti-oksidan yang sangat rendah dan tidak berpotensi sebagai anti-kanker terhadap sel HeLa secara in vitro. KATA KUNCI : Annona muricata Linn, anti-oksidan, kanker, sitotoksisitas ABSTRACTBackground: Cervical cancer is the second leading cause of death in women. Various supporting therapies have been developed, such as through food ingredients which are believed to have anti-cancer effects. Soursop is known to be high phytochemical content such as Annonaceous acetogenin, flavonoid and phenols which are useful as anti-cancer. Objectives: This research was conducted to determine the antioxidant and cytotoxic activity of soursop juice on HeLa cell lines.Methods: This study started by making the soursop fruit extract by blending then dried with freeze-drying method, and then proceed with 2.2-diphenyl-1-picrylhydrazyl (DPPH) assay to determine the potential free radical scavenging activity, cytotoxic potential activity in vitro through MTT (3-(4,5-dimethylthiazol-2-il)-2,5-difenitetrazolium bromide) assay on HeLa cell lines.Results: The IC50 antioxidant activity of soursop fruit extract is 3549 μg/mL with linear regression equation (y=0.0149x – 2.8812) and the IC50 cytotoxicity test of soursop fruit extracton HeLa was 2522,33 μg/mL with linier regression equation (y=0.0197x + 0.3101). Conclusion: The conclusion in this study is that soursop fruit extract has very low antioxidant activity and has no in vitro potential effect as an anti-cancer on HeLa cell lines. KEYWORDS : Annona muricata Linn, antioxidant, cancer, cytotoxic

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Immunomodulatory Effects of Medicinal Plants used for Vitiligo in Traditional Persian Medicine

Ebrahimabadi

Lamardi

Shirbeigi

2021

CDDT

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Background: Vitiligo is a hypopigmentation disorder that affects 1% of the world's population. Vitiligo causes white spots on the skin, mucous membranes, or white hair by destroying skin melanocytes. The pathogenesis of vitiligo is unknown, but autoimmune, autocytotoxic, and neural mechanisms are suggested. According to the autoimmune theory, in people with vitiligo, immune cells invade and damage melanocytes. T cells are more commonly present in vitiligo patients' skin and remain in the lesion site, which is composed of CD8 and CD4 T cells. Many studies have been conducted on the presence and role of cytokines such as interleukins and interferon gamma (IFN-γ) in the vitiligo process. Aim: This study aimed to introduce herbs effective against vitiligo from the perspective of Persian medicine and to investigate their possible therapeutic mechanisms with the possible effects of herbs on autoimmune mechanisms. Methods: For this purpose, keywords were used to extract data from Persian medicine textbooks, and then relevant scientific databases including Google Scholar, PubMed, Web of Science, and Scopus were examined. Results: It was found that Persian medicine scholars used 50 different medicinal plants to treat and reduce the complications of vitiligo, and recent scientific studies have the proven immune-regulating properties and reducing effect of many of them on cytokines. Conclusion: According to scientific evidence on immunomodulatory effects, new research into the effects of these plants on vitiligo can lead to the discovery of new drugs and approaches for treating this disease.

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Evaluation of ethanolic extract of Cucumis melo L. for inflammation and hyperplasia of prostate

Cited by 3 publications

References 3 publications

Phytochemical, Free Radical Scavenging and Cytotoxic Assay of Cucumis Melo L. Extract and β-Carotene

Phytochemical, Free Radical Scavenging and Cytotoxic Assay of Cucumis Melo L. Extract and β-Carotene

Free radical scavenging and cytotoxic assay of soursop fruit juice (Annona muricata Linn.) on cervical cancer cell lines (HeLa)

Immunomodulatory Effects of Medicinal Plants used for Vitiligo in Traditional Persian Medicine

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