Evaluation of epicardial fat tissue thickness in patients with <scp>H</scp>ashimoto thyroiditis

Aşık, Mehmet; Şahin, Sinan; Özkul, Faruk; Anaforoğlu, İnan; Ayhan, Semiha; Karagol, S.; Güneş, Fahri; Algün, Ekrem

doi:10.1111/cen.12176

Cited by 35 publications

(34 citation statements)

References 27 publications

(72 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This observation is in line with the majority of previous studies of EAT thickness in SCH [10][11][12][13]. These data suggest that increased EAT thickness in SCH is not just an observational coincidence, but mostly related the effects of thyroid hormones on the heart and adipose tissue [11][12][13].…”

Section: Discussionsupporting

confidence: 91%

“…The reports concerning EAT thickness in patients with SCH are somewhat conflicting: while EAT thickness was pre-viously reported to be increased in patients with SCH when compared to euthyroid controls [11][12][13], a recent study did not find any such difference, and EAT thickness was not associated with cardiovascular risk in SCH patients [14].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thickening of the epicardial adipose tissue can be alleviated by thyroid hormone replacement therapy in patients with subclinical hypothyroidism

et al. 2016

View full text Add to dashboard Cite

A b s t r a c tBackground: Subclinical hypothyroidism (SCH) is a common disorder which has adverse cardiovascular effects. Epicardial adipose tissue (EAT), a novel marker of cardiovascular risk, is increased in SCH. Aim:We aimed to investigate whether L-thyroxine treatment can reverse the thickening of EAT in SCH. Methods:Forty-four patients with SCH and 42 euthyroid control subjects were included. EAT thickness was measured using transthoracic echocardiography at baseline and after restoration of the euthyroid status with 3 months of L-thyroxine treatment.Results: At baseline, mean EAT thickness was significantly greater in the SCH group when compared to the control group (6.3 ± 1.7 mm vs. 4.1 ± 0.9 mm, respectively, p < 0.001). There was a significant positive correlation between baseline serum thyroid stimulating hormone (TSH) level and EAT thickness in the SCH group. There was a significant reduction in mean EAT thickness in response to L-thyroxine treatment (6.3 ± 1.7 mm vs. 5.1 ± 1.4 mm, p < 0.001). The decrease in EAT thickness after L-thyroxine treatment when compared to baseline (DEAT) significantly correlated to the difference in TSH levels before and after treatment (DTSH; r = 0.323; p = 0.032). Conclusions:Epicardial adipose tissue thickness is increased in patients with SCH. This thickening was alleviated with restoration of the euthyroid status with L-thyroxine treatment in our study population of predominantly male, relatively old subjects with greater baseline EAT thickness.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Thickening of the epicardial adipose tissue can be alleviated by thyroid hormone replacement therapy in patients with subclinical hypothyroidism

et al. 2016

View full text Add to dashboard Cite

show abstract

“…There are many data in the literature suggesting that both overt and subclinical hyperthyroid is associated with increased cardiovascular diseases [15,16]. …”

Section: Discussionmentioning

confidence: 99%

Myocardial Performance Index for Patients with Overt and Subclinical Hypothyroidism

2017

View full text Add to dashboard Cite

BackgroundHypothyroid has several effects on the cardiovascular system. Global myocardial performance index (MPI) is used in assessment of both left ventricular (LV) systolic and diastolic function. We compared MPI in hypothyroidism patients vs. normal control subjects.Material/MethodsEighty-two hypothyroid patients were divided into 2 groups: a subclinical hypothyroid (SH) group (n=50), and an overt hypothyroid (OH) group (n=32). The healthy control group (CG) constituted of 37 patients. TSH, FT3, and FT4, anti-TPO, anti-TG, insulin, lipid values, and fasting glucose levels were studied. All patients underwent an echocardiographic examination. Myocardial performance indexes were assessed and standard echocardiographic examinations were investigated.ResultsMPI averages in OH, SH, and control groups were 0.53±0.06, 0.51±0.05, and 0.44±0.75 mm, respectively. MPI was increased in the OH and SH groups in comparison to CG (p<0.001, p<0.001, respectively).ConclusionsMPI value was significantly higher in hypothyroid patients in comparison to the control group, showing that regression in global left ventricular functions is an important echocardiographic finding. Future studies are required to determine the effects of this finding on long-term cardiovascular outcomes.

show abstract

“…104,105 It is also of interest that epicardial fat, another form of abnormal fat accumulation, is associated with SCH, NAFLD, MetS and vascular risk. 106,107 There is more to BP assessment than just occasional office-based measurements. Therefore, it is of interest that raised TSH levels have been linked to decreased nocturnal BP-dipping.…”

Section: Other Less Well Established Links Between Sch and Vascular Riskmentioning

confidence: 99%

Subclinical hypothyroidism and vascular risk: Αn update

Lioudaki¹,

Mavroeidi²,

Mikhailidis³

et al. 2013

View full text Add to dashboard Cite

subclinical hypothyroidism (scH), defined as elevated serum thyroid-stimulating hormone (tsH) in the presence of normal circulating free thyroxine (Ft4) and triiodothyronine (t3), is a relatively common condition. replacement treatment with levothyroxine is justified only for individuals with tsH levels >10 mIU/l. serum lipid levels are influenced by thyroid status and there is evidence pointing to a link between scH and an unfavorable lipid profile. Despite some conflicting data, most studies suggest that levothyroxine treatment may exert a beneficial effect on the lipid profile in scH regarding mainly total cholesterol and low-density lipoproteincholesterol. Moreover, it appears that treatment may also improve some other markers associated with cardiovascular (cV) disease such as carotid intima media thickness ( 17-03-201317-03- , Accepted 20-10-2013 Review (FT4) and triiodothyronine (T3) levels within the reference range.1 This is a relatively common condition with a prevalence ranging from 4 to 15% in the general population and up to 20% among females aged >60 years. [2][3][4][5]

show abstract

Evaluation of epicardial fat tissue thickness in patients with Hashimoto thyroiditis

Abstract: Epicardial fat tissue thickness may be a useful indicator of early atherosclerosis in SCH and OH patients with HT.

Cited by 35 publications

References 27 publications

Thickening of the epicardial adipose tissue can be alleviated by thyroid hormone replacement therapy in patients with subclinical hypothyroidism

Thickening of the epicardial adipose tissue can be alleviated by thyroid hormone replacement therapy in patients with subclinical hypothyroidism

Myocardial Performance Index for Patients with Overt and Subclinical Hypothyroidism

Subclinical hypothyroidism and vascular risk: Αn update

Contact Info

Product

Resources

About