Thickening of the epicardial adipose tissue can be alleviated by thyroid hormone replacement therapy in patients with subclinical hypothyroidism

Sayin, Irmak; Erkan, Aycan Fahri; Ekici, Berkay; Kütük, Utku; Çorakçı, Ahmet; Töre, Hasan Fehmi

doi:10.5603/kp.a2016.0053

Cited by 8 publications

(5 citation statements)

References 18 publications

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“… Author Year Country Participants (SCH/EU) Age (SCH/EU) Study design TSH cutoff value T4 measured? Measure outcomes NOS Score Ali Aydogdu 33 2017 Turkey 30/30 37.70 ± 13.54/40.96 ± 13.39 Case-control study ≥5.5 mIU/L + EAT thickness 7 Pramila Kalra 39 2016 Canada 58/49 31.83 ± 8.91/32.42 ± 9.98 Case-control study >4.5 mIU/L + PWV 5 Edip Unal 50 2017 Turkey 38/38 8.1 ± 3.6/8.9 ± 2.4 Case-control study >4.2 mIU/L + CIMT 8 Irmak Sayin 48 2016 Turkey 44/42 41.2 ± 15.9/42.1 ± 13.5 Case-control study >5.0 mIU/L + EAT thickness 8 Mustafa Altay 30 2017 Turkey 35/30 34.4 ± 10.3/32.5 ± 7.5 Case-control study — + CIMT 4 Yasemin Isik-Balci 38 2016 Turkey 53/31 9.25 ± 4.29/7.19 ± 5.15 Case-control study — + CIMT 4 Dilek Arpaci 31 2016 Turkey 41/35 34.07 ± 6.70/31.82 ± 5.57 Case-control study >5.4 mIU/L + EA...…”

Section: Methodsmentioning

confidence: 99%

Non-invasive markers of cardiovascular risk in patients with subclinical hypothyroidism: A systematic review and meta-analysis of 27 case control studies

Yao

Zhao

Zeng

et al. 2018

Sci Rep

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It has been reported that subclinical hypothyroidism (SCH) is closely related to subclinical atherosclerosis. According to the impact of SCH on noninvasive markers of cardiovascular risk, we fulfilled a meta-analysis of included studies to provide an integrated overview. We searched electronic databases and included all relevant studies involving SCH and epicardial adipose tissue (EAT), carotid intima-media thickness (CIMT), pulse wave velocity (PWV), flow-mediated dilation (FMD) and glyceryl trinitrate-induced dilation (GNT- induced dilation). The result was calculated in a meta-analysis to assess the impact of SCH on these markers. A total of 27 studies were entered in the final analysis. Compared with euthyroid subjects, SCH patients exhibited a significantly increased CIMT (SMD: 0.369 mm; 95%CI: 0.038, 0.700; P = 0.029) and EAT (SMD: 1.167 mm; 95%CI: 0.869, 1.466; P = 0.000) and increased PWV (SMD: 3.574 m/s; 95%CI: 0.935, 6.213, P = 0.008). We also found significantly lower FMD (SMD: −1.525%, 95%CI: −2.156, −0.894, P = 0.000) and lower GNT-induced dilation (SMD: −0.384%, 95%CI: −0.625, −0.142, P = 0.002). Sensitivity analysis and subgroup analysis confirmed the above results. Our meta-analysis confirmed a significant association of SCH and cardiovascular risk with arterial wall thickening and stiffening and endothelial dysfunction. These findings will help to establish detailed cardiovascular prevention strategies for SCH patients.

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Section: Methodsmentioning

confidence: 99%

Non-invasive markers of cardiovascular risk in patients with subclinical hypothyroidism: A systematic review and meta-analysis of 27 case control studies

Yao

Zhao

Zeng

et al. 2018

Sci Rep

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“…The reason for this finding could be only speculated and further studies are needed concerning regional fat distribution (e.g. visceral and/or epicardial) in both active males and females in the context of normal circulating TSH (Korkmaz et al, 2013;Belen et al, 2015;Sayin et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Normal Levels of TSH Affect the Metabolic Profile Differently in Physically Active Males and Females

Malara

Kęska

Tkaczyk

et al. 2021

Central European Journal of Sport Sciences and Medicine

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Our study was aimed at the evaluation of relationships between thyroid stimulating hormone (TSH) within the normal range and metabolic risk factors (glucose, insulin, HOMA-IR and lipoprotein profile) in physically active male and female students. In 219 students circulating TSH, glucose, insulin and lipoproteins were measured in blood under fasting conditions. Insulin resistance was expressed as HOMA-IR (homeostasis model assessment for insulin resistance). For further procedures 99 males and 97 regularly menstruating females with TSH 0.4-4.0 µIU/ml were accepted. In male students no correlations between circulating TSH, anthropometric and biochemical variables were noted. In females TSH within the normal range was slightly but significantly correlated with the triglyceride (TG) level (p < 0.03). However, step-wise multiple regression analysis revealed that the effect of TSH was small (p < 0.046) in relation to that found for HOMA-IR (p < 0.0009). No relationships between biochemical variables and normal levels of TSH were noted in male students. However, surprisingly normal range TSH in males was slightly but significantly correlated with the percentage of body fat and this issue needs further studies concerning measurements of different fat depots. The above data suggests that in active females TG synthesis and export from the liver is more sensitive to TSH action than in active male counterparts.

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Section: Discussionmentioning

confidence: 99%

Normal levels of TSH affect the metabolic profile differently in physically active males and females

Malara

Tkaczyk

Kęska

et al. 2020

Preprint

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Background Our study was aimed at the evaluation of relationships between thyroid stimulating hormone (TSH) within the normal range and metabolic risk factors (glucose, insulin, HOMA-IR and lipoprotein profile) in physically active male and female students. Methods In 112 male and 107 female students circulating TSH, glucose, insulin and lipoproteins (triacylglycerols, total cholesterol, HDL-cholesterol and LDL-cholesterol) were measured in blood under fasting conditions. Insulin resistance was expressed as HOMA-IR. For further procedures 99 males and 97 regularly menstruating females with TSH 0.4 – 4.0 µIU/ml were accepted. Results In male students no correlations between circulating TSH, anthropometric and biochemical variables were noted. In females TSH within the normal range was slightly but significantly correlated with the triglyceride (TG) level (p<0.03). However, step-wise multiple regression analysis revealed that the effect of TSH was small (p<0.046) in relation to that found for HOMA-IR (p<0.0009). No relationships between biochemical variables and normal levels of TSH were noted in male students. However, surprisingly normal range TSH in males was slightly but significantly correlated with the percentage of body fat and this issue needs further studies concerning measurements of different fat depots.Conclusions The above data suggests that in active females TG synthesis and export from the liver is more sensitive to TSH action than in active male counterparts.

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Thickening of the epicardial adipose tissue can be alleviated by thyroid hormone replacement therapy in patients with subclinical hypothyroidism

Cited by 8 publications

References 18 publications

Non-invasive markers of cardiovascular risk in patients with subclinical hypothyroidism: A systematic review and meta-analysis of 27 case control studies

Non-invasive markers of cardiovascular risk in patients with subclinical hypothyroidism: A systematic review and meta-analysis of 27 case control studies

Normal Levels of TSH Affect the Metabolic Profile Differently in Physically Active Males and Females

Normal levels of TSH affect the metabolic profile differently in physically active males and females

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