Evaluation of endometrial receptivity during <i>in‐vitro</i> fertilization using three‐dimensional power Doppler ultrasound

Järvelä, Ilkka Y.; Sladkevicius, Povilas; Kelly, Simon; Ojha, Kamal; Campbell, Stuart; Nargund, Geeta

doi:10.1002/uog.2628

Cited by 106 publications

(96 citation statements)

References 15 publications

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“…Jarvela et al [22] reported that in women undergoing IVF, when using threedimensional Doppler ultrasound, a triple-line pattern after FSH stimulation and a decrease in endometrial volume was associated with conception. However, Sterzik et al [23] concluded that ultrasonography is an inadequate method to predict endometrial receptivity in IVF cycles, since neither the endometrial thickness nor the echo pattern correlate with the histologic findings.…”

Section: Ultrasoundmentioning

confidence: 99%

Uterine receptivity to human embryonic implantation: Histology, biomarkers, and transcriptomics

Aghajanova¹,

Hamilton²,

Giudice³

2008

Seminars in Cell & Developmental Biology

138

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Embryonic implantation is a dynamic process of paracrine interactions between the maternal compartment and the conceptus and involves a receptive endometrium and a developmentally competent blastocyst. Herein, we review histology, clinical approaches, and the promise of transcriptomics in elucidating mechanisms underlying implantation and development of biomarkers of uterine receptivity -with an eye to diagnose and treat implantation-based disorders of miscarriage, fetal growth restriction, pre-eclampsia, and infertility.Keywords human implantation; endometrium; microarray; blastocyst Challenges and approaches in studying the process of human implantation Clinical implicationsSuccessful embryo implantation is a crucial event in natural and assisted human reproduction. Blastocyst implantation is a dynamic process, involving embryo apposition, attachment to the maternal endometrial epithelium, and invasion into the endometrial stroma [1]. With in vitro fertilization (IVF), implantation failure can occur due to several factors [2], including embryonic defects such as chromosomal abnormalities, which are the most common cause of implantation failure [3,4]. Another widely acknowledged barrier to successful blastocyst implantation and, therefore, successful treatment of infertile women with implantation failure, is an inappropriately developed endometrium. It is well established that embryos cannot implant in a poorly matured endometrium [5], and this may be responsible for low implantation rates with transfer of "good quality" embryos. The success of embryonic implantation further relies upon cross-talk between the embryo and a receptive endometrium [5]. Optimization of IVF results are important for many reasons, and achieving optimal implantation is even more important in the setting of single embryo transfer, a common practice aimed to avoid multiple pregnancies.Corresponding author: Linda C. Giudice, MD, PhD, MSc, Professor and Chair, Department of Obstetrics, Gynecology and Reproductive Sciences, The Robert B. Jaffe, MD Endowed Professor in the Reproductive Sciences, University of California, San Francisco, 505 Parnassus Ave., M1496, Box 0132, San Francisco, CA 94143-0132, Tel: +1 4154762564, Fax: +1 415476181, giudice@obgyn.ucsf.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. The implantation window and challenges of studying it NIH Public AccessThe endometrium is receptive to blastocyst implantation during a spatially and temporally restricted "window", when the luminal epithelium is favorable for blastocyst implantation even in the absence of an implanting ...

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Section: Ultrasoundmentioning

confidence: 99%

Uterine receptivity to human embryonic implantation: Histology, biomarkers, and transcriptomics

Aghajanova¹,

Hamilton²,

Giudice³

2008

Seminars in Cell & Developmental Biology

138

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“…[9][10][11][12][13][14][15][16][17] Other applications of 3-dimensional sonography of the endometrium include endometrial volume measurements in patients with postmenopausal bleeding, assessment of intracavitary lesions, evaluation of endometrial receptivity during in vitro fertilization, localization of the maximal implantation point during sonographically guided embryo transfer, and use in association with extrauterine gestations. [18][19][20][21][22][23] Recently, 3-dimensional transvaginal sonography of the endometrium has assisted the diagnosis of interstitial and intramural pregnancies. [24][25][26] In these cases, as in our case of a cervical pregnancy, 3-dimensional transvaginal sonography of the endometrium enabled precise depiction of the intact endometrium and the presence of an adjacent gestational sac located within the myometrium or uterine cervix, respectively.…”

Section: Discussionmentioning

confidence: 99%

Three-Dimensional Sonographic Findings of a Cervical Pregnancy

Sherer

Gorelick

Dalloul

et al. 2008

Journal of Ultrasound in Medicine

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cervical pregnancy is an uncommon ectopic pregnancy that accounts for less than 1% of such gestations. 1 This condition is associated with an extremely high risk of massive hemorrhage and previously often required hysterectomy. 1 The current diagnostic modality of this potentially lifethreatening condition is transvaginal sonography, supported at times by magnetic resonance imaging. [2][3][4] The definitive diagnostic imaging feature of a cervical pregnancy is the location of a gestational sac in the cervix in the presence of a closed internal uterine cervical os. [2][3][4][5][6][7] We report the 3-dimensional transvaginal sonographic findings of a cervical pregnancy at 6 weeks' gestation.Received August 8, 2007, Case ReportA 34-year-old woman, gravida 3, para 0, came to the emergency department at State University of New York Downstate Medical Center with mild uterine hemorrhage. Her medical history was unremarkable. The patient had 2 previous spontaneous first-trimester miscarriages. Physical examination revealed a healthy individual. She was afebrile with a blood pressure of 120/78 mm Hg, a pulse of 84 beats per minute, and a respiratory rate of 20 breaths per minute. Her abdomen was soft and nontender, with no peritoneal signs elicited. Bimanual pelvic examination disclosed a soft, mildly enlarged uterus. Both adnexa were normal. The cervix was long and closed and appeared boggy on inspection.Laboratory test results revealed a hemoglobin level of 13.6 g/dL, a hematocrit value of 42%, a white blood cell count of 7.29 × 10 9 /L, and a platelet count of 255 × 10 9 /L.

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“…a) The first studies reported a good correlation between endometrial volume and pregnancy (31)(32)(33). Although it has been shown that the endometrium must attain at least 2.0-2.5 ml to achieve a pregnancy, recent studies did not confirm the relation between endometrial volume and pregnancy outcome (33)(34)(35)(36)(37). In our study, the area under the receiver operating characteristic (ROC) curve was statistically significant for endometrial volume when no grade 1 embryos or only one were transferred but not significant when two or three grade 1 embryos were transferred (34).…”

Section: Endometrial Receptivitymentioning

confidence: 99%

Three-dimensional ultrasound as a predictor of pregnancy in patients undergoing ART

Yaman

Mayer

2012

J Turkish German Gynecol Assoc

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Evaluation of endometrial receptivity during in‐vitro fertilization using three‐dimensional power Doppler ultrasound

Abstract: Objective To compare sonographic endometrial characteristics in in-vitro fertilization (IVF)

Cited by 106 publications

References 15 publications

Uterine receptivity to human embryonic implantation: Histology, biomarkers, and transcriptomics

Uterine receptivity to human embryonic implantation: Histology, biomarkers, and transcriptomics

Three-Dimensional Sonographic Findings of a Cervical Pregnancy

Three-dimensional ultrasound as a predictor of pregnancy in patients undergoing ART

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