Evaluation of embryotoxicity for major components of herbal extracts using the chick embryonic heart micromass and mouse D3 embryonic stem cell systems

Mohammed, Omar J.; Latif, M.L.; Pratten, Margaret K.

doi:10.1016/j.reprotox.2015.12.003

Cited by 8 publications

(8 citation statements)

References 70 publications

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“…Furthermore, the development of the heart; neural tube; cerebral vesicles; otic, optic, and Rg1 Regulate Mesenchymal Stem Cells olfactory organs; branchial arch; maxilla; mandible; yolk sac vasculature; and allantois was also affected by increased concentrations of Rg1 (Liu et al, 2006). In contrast, a low concentration of Rg1 (62.5-10000 nM) may have a slight effect on chick cardiomyocytes and mouse D3 stem cells (Mohammed et al, 2016). Therefore, pregnant women should be cautious when using ginseng or ginsenoside Rg1 during the first three months of pregnancy.…”

Section: Optimization Of the Effective Concentration Of Rg1mentioning

confidence: 99%

“…Traditionally, the active ingredients in ginseng are believed to be good nutritional supplements for pregnant women and beneficial for fetal development (Tiran, 2003;Ong et al, 2005). Recent studies have found that some concentration of Rg1 may have embryotoxic effects (Liu et al, 2006;Mohammed et al, 2016). In studies using the whole embryo culture technique, culturing with Rg1 (62.4 mM for mice and 37.4 mM for rats) for 48 h reduced the total embryo morphological score, which is based on the crown-rump length, head length, flexion scores, forelimb bud scores, and hindlimb bud scores.…”

Section: Optimization Of the Effective Concentration Of Rg1mentioning

confidence: 99%

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Ginsenoside Rg1 as an Effective Regulator of Mesenchymal Stem Cells

Liu

et al. 2020

Front. Pharmacol.

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Recently, breakthroughs have been made in the use of mesenchymal stem cells (MSCs) to treat various diseases. Several stem cell types have been authorized as drugs by the European Medicines Agency and the U.S. Food and Drug Administration. The Chinese official document "Notification of the management of stem cell clinical research (trial)" was also published in August 2015. Currently, China has approved 106 official stem cell clinical research filing agencies and 62 clinical research projects, which are mostly focused on MSC therapy. Hence, the optimization and development of stem cell drugs is imperative. During this process, maximizing MSC expansion, minimizing cell loss during MSC transplantation, improving the homing rate, precisely regulating the differentiation of MSCs, and reducing MSC senescence and apoptosis are major issues in MSC preclinical research. Similar to artemisinin extracted from the stems and leaves of Artemisia annua, ginsenoside Rg1 (Rg1) is purified from the root or stem of ginseng. In the human body, Rg1 regulates organ function, which is inseparable from its regulation of adult stem cells. Rg1 treatment may effectively regulate the proliferation, differentiation, senescence, and apoptosis of MSCs in different microenvironments in vitro or in vivo. In this review, we discuss recent advances in understanding the effect of Rg1 on MSCs and describe the issues that must be addressed and prospects regarding Rg1 regulation of MSCs in preclinical or clinical studies.

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Section: Optimization Of the Effective Concentration Of Rg1mentioning

confidence: 99%

Section: Optimization Of the Effective Concentration Of Rg1mentioning

confidence: 99%

Ginsenoside Rg1 as an Effective Regulator of Mesenchymal Stem Cells

Liu

et al. 2020

Front. Pharmacol.

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“…disruption of angiogenesis). It is confirmed by its capacity to inhibit the proliferation and tube formation of primary cultured human endothelial cells through down regulation of cyclidin D and also inhibition of tumor growth in mice by its anti-angiogenic activity [43]. Moreover, it can induce apoptosis, DNA mutation, decrease cell migration and motility in a dose dependent manner, arresting the cell cycle and stop cancer cells proliferation.…”

Section: Ginger (Zingiber Officinale)mentioning

confidence: 84%

Herbal laxatives and antiemetics in pregnancy

Samavati

Ducza

Hajagos-Tóth

et al. 2017

Reproductive Toxicology

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a b s t r a c tConstipation appears in the 2nd and 3rd trimester of pregnancy, while nausea is the strongest in the 1st trimester. This review summarizes the applicability of herbal laxatives and antiemetics in pregnancy.A human study has shown that flax oil as laxative is safe from 2nd trimester. Human data is not available about the rhubarb, but animal studies reveal that its emodin content induces fetal abnormalities. Fenugreek induces teratogenic malformation both in human and animals. Senna seed is proved as a safe laxative in pregnancy. The antiemetic ginger is safe during 1st trimester, but it reduces the gestational period when applied from the 2nd trimester. Cannabis induces fetal neurological disorders while fennel can shorten the gestational age.There is herbal alternative for laxative therapy (senna) for the whole length of pregnancy, but nausea and vomiting might be reduced by herbal medicine (ginger) safely in the 1st trimester, only.

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“…However, the focus is currently not only on drugs but also natural products. Some natural products which are commonly consumed, including ginseng, ginger, and ginko biloba, reported to inhibit fetal growth (Mohammed et al., 2016). Another surprising study by Park et al.…”

Section: Introductionmentioning

confidence: 99%

“…Unfortunately, there has no study investigating the effect of propolis administration on fetal development, where its biological activities may affect. The antitumor activity of natural product could inhibit embryonic cells development (Mohammed et al., 2016), while propolis has been reported to possess that activity (Suzuki et al., 2002; Oršolić; Bašić, 2003; Oršolic et al., 2005; Xuan et al., 2014). However, the chemical composition of propolis depends on location, season, bee species, and method of preparation (Salatino et al., 2005; Sun et al., 2015).…”

Section: Introductionmentioning

confidence: 99%

The effect of propolis administration on fetal development

Fikri

Sulaeman

Handharyani

et al. 2019

Heliyon

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Propolis is one of the bee products that widely used in health therapy. However, there has no study evaluating the developmental toxicity of propolis. This study was aimed to analyze the effect of propolis administration during pregnancy on fetal development. The pregnant mice were divided into five groups including control group (Tween 80 1%), low-dose (380 mg/kg b.wt.) and high-dose (1400 mg/kg b.wt.) of water extract of propolis from Banten (WEB), and low-dose (380 mg/kg b.wt.) and high-dose (1400 mg/kg b.wt.) of ethanol extract of propolis from South Sulawesi (EES). Propolis was administered for 18 days of gestation and then sacrificed to analyze the fetal development by examining external and skeletal abnormalities. The histopathological examination of placenta was also conducted. The result showed both low-dose groups did not inhibit fetal development. However, the high-dose of EES significantly reduced the weight, crown-rump of fetuses and increased the number of resorption (p < 0.05). Fetal weight was the only significantly reduced parameter of fetal growth in the highdose group of WEB (p < 0.05). The histopathological examination of placenta showed a reduction of labyrinth development in both high-dose groups. Dose of 380 mg/kg dose of Indonesian propolis is relatively safe for consumption during pregnancy.

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Evaluation of embryotoxicity for major components of herbal extracts using the chick embryonic heart micromass and mouse D3 embryonic stem cell systems

Cited by 8 publications

References 70 publications

Ginsenoside Rg1 as an Effective Regulator of Mesenchymal Stem Cells

Ginsenoside Rg1 as an Effective Regulator of Mesenchymal Stem Cells

Herbal laxatives and antiemetics in pregnancy

The effect of propolis administration on fetal development

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