Evaluation of efficacy of an inactivated vaccine against bovine respiratory syncytial virus in calves with maternal antibodies

Patel, Jay; Didlick, S

doi:10.2460/ajvr.2004.65.417

Cited by 26 publications

(25 citation statements)

References 24 publications

(20 reference statements)

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“…Further, Patel and Didlick (2004) reported no increase in antibody titers in calves receiving a modified-live BRSV vaccine.…”

Section: Discussionmentioning

confidence: 99%

Effects of Supplemental Lysine on Performance, Antibody Titer and Rectal Temperature in Response to a Modified-Live Viral Vaccine in Neonatal Calves

Sharon¹,

Duff²,

Dailey³

et al. 2014

American Journal of Animal and Veterinary Sciences

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Infectious Bovine Rhinotracheitis (IBR), caused by bovine herpesvirus-1, contributes significantly to economic losses in the dairy and beef cattle industry. Lysine has been shown reduce virulence of herpesviruses in felids and humans. Our objective was to evaluate the effects of supplemental lysine on serum IBR antibody titer and rectal temperature in response to a modified-live Intranasal ( and CAS treated calves (p>0.10). However, serum urea nitrogen and the ratio of serum lysine: Arginine increased (p<0.05) for LYS compared to CAS calves. These results suggest that supplementing lysine impacts nitrogen metabolism but does not alter the response to IBR vaccination or animal performance in neonatal Holstein calves.

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“…Further, Patel and Didlick (2004) reported no increase in antibody titers in calves receiving a modified-live BRSV vaccine.…”

Section: Discussionmentioning

confidence: 99%

Effects of Supplemental Lysine on Performance, Antibody Titer and Rectal Temperature in Response to a Modified-Live Viral Vaccine in Neonatal Calves

Sharon¹,

Duff²,

Dailey³

et al. 2014

American Journal of Animal and Veterinary Sciences

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“…Therefore, administration of bRSV vaccines to cows in late gestation to boost antibody titers in colostrum may be a rational strategy to deal with bRSV-induced respiratory disease in young calves (1-3 months of age) in problem herds. This would eliminate the concern regarding the immunizing potential of particular parenteral vaccines in young seropositive calves, as there are conflicting data concerning the ability of currently available commercial inactivated parenteral bRSV vaccines to override maternal antibodies and stimulate protective responses, features that may be related to the vaccine formulation and adjuvant [67,68]. Similarly, although not formally examined in disease-producing experimental challenge models, it is porbably that parenterally administered MLV vaccines would also not override suppressive maternal antibodies, especially since there is limited replication of bRSV in tissues outside the respiratory tract.…”

Section: Passive Immunoprophylaxismentioning

confidence: 96%

Immunization strategies for the prevention of pneumovirus infections

Bennett

Ellis

Bonville

et al. 2007

Expert Review of Vaccines

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Pneumoviruses, which are viruses of the family Paramyxoviridae, subfamily Pneumovirinae, are pathogens that infect the respiratory tract of their host species. The human pneumovirus pathogen, human respiratory syncytial virus (RSV), has counterparts that infect cows (bovine RSV), sheep (ovine RSV), goats (caprine RSV) and rodents (pneumonia virus of mice). Each pneumovirus is host specific and results in a spectrum of disease, ranging from mild upper-respiratory illness to severe bronchiolitis and pneumonia with significant morbidity and mortality. Given the public health burden caused by human RSV and the concomitant agricultural impact of bovine RSV, these two viruses are considered as prime targets for the development of safe and effective vaccines. In this review, we describe the strategies used to develop vaccines against human and bovine RSV and introduce the pneumonia virus mouse model as a novel and invaluable tool for preclinical studies and new vaccine strategies.

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“…Good growth is even less likely with deletion mutant BRSV strains. An interesting approach to overcome poor and inconsistent yield of BRSV antigens has been to derive persistently infected BRSV bovine cell lines [37]. All cells in such cell lines are viable and express BRSV antigens upon routine subculture [37].…”

Section: Bovine Respiratory Disease Complexmentioning

confidence: 99%

Immunoprophylaxis against important virus diseases of horses, farm animals and birds

Patel¹,

Heldens²

2009

Vaccine

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Since the refinement of tissue culture techniques for virus isolation and propagation from the mid 1960s onwards, veterinary virology has received much academic and industrial interest, and has now become a major global industry largely centred on vaccine development against economically important virus diseases of food animals. Bio-tech approaches have been widely used for improved vaccines development. While many viral diseases are controlled through vaccination, many still lack safe and efficacious vaccines. Additional challenges faced by academia, industry and governments are likely to come from viruses jumping species and also from the emergence of virulent variants of established viruses due to natural mutations. Also viral ecology is changing as the respective vectors adapt to new habitats as has been shown in the recent incursion by bluetongue virus into Europe. In this paper the current vaccines for livestock, horses and birds are described in a species by species order. The new promising bio-tech approaches using reverse genetics, non-replicating viral vectors, alpha virus vectors and genetic vaccines in conjunction with better adjuvants and better ways of vaccine delivery are discussed as well

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Evaluation of efficacy of an inactivated vaccine against bovine respiratory syncytial virus in calves with maternal antibodies

Abstract: Through vaccination, it is possible to protect vulnerable calves with maternal antibodies against BRSV infection and reduce respiratory tract disease.

Cited by 26 publications

References 24 publications

Effects of Supplemental Lysine on Performance, Antibody Titer and Rectal Temperature in Response to a Modified-Live Viral Vaccine in Neonatal Calves

Effects of Supplemental Lysine on Performance, Antibody Titer and Rectal Temperature in Response to a Modified-Live Viral Vaccine in Neonatal Calves

Immunization strategies for the prevention of pneumovirus infections

Immunoprophylaxis against important virus diseases of horses, farm animals and birds

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