Evaluation of effects of magnesium sulphate in reducing intraoperative anaesthetic requirements

Abstract

The administration of magnesium led to a significant reduction in the requirements for anaesthetic drugs during total i.v. anaesthesia with propofol, remifentanil and vecuronium.

Magnesium sulphate effects on sugammadex reversal time – a reply

“…Participant safety is fundamental to the conduct of ethical clinical research, and is protected by formal commit-tee review and sanction, as occurred for our study. Although this study could have been considered to have hypothesised harm, this was in the knowledge that there are also treatment benefits when using magnesium sulphate during nasal endoscopic surgery, including relative hypotension (which helps optimise surgical view), improved pain control and reduced intra-operative anaesthetic requirements [2][3][4][5][6]. Furthermore any 'harm' (including aspiration of gastric contents or other respiratory complications) associated with residual neuromuscular blockade [6] was minimised by extubating the trachea only when the T4/T1 ratio was equal to or greater than 0.9 after sugammadex administration; all patients remained in the postoperative care unit, with objective neuromuscular transmission monitoring.…”

Usos do sulfato de magnésio em obstetrícia e em anestesia

“…c) It can increase the synthesis of prostacyclins and inhibit angiotensin converting enzyme, leading to vasodilation 11 . d) It decreases the release of catecholamines after sympathetic stimulus 1,5,9,11 . It has been used in the treatment of pheochromocytoma-related hypertensive episodes during surgeries or outside the surgical environment 5 .…”

“…Magnesium is considered a natural physiologic calcium antagonist, having several regulatory mechanisms, such as [1][2][3][8][9][10][11] : competitive antagonist affecting type L calcium channels, inhibition of the enzyme Ca 2+ -ATPase, and it is a cofactor for all enzymes that participate in phosphate transferences that use ATP. In high concentrations, it inhibits the enzyme Na + /K + -ATPase 5 .…”

“…Magnesium has been used to attenuate the cardiovascular response to tracheal intubation 5 . This effects is, probably, secondary to a reduction in the release of catecholamines after sympathetic stimulation 1,3,5,11,34,35 . A 40 mg.kg -1 dose has shown similar efficacy to that of 10 µg.kg -1 of alfentanil as well as greater effectivity than 1.5 mg.kg -1 of lidocaine 5 .…”

“…Magnesium is the second most abundant intracellular cation 1,2 and the fourth when the extracellular medium is also considered 1 . As a cofactor, it is involved in more than 300 known reactions, such as 3 : hormone binding to receptors, flow of transmembrane ions, regulation of the adenylate kinase system, muscle contraction, neuronal activity, vasomotor tone, cardiac excitability, release of neurotransmitters, and calcium binding to calcium channels.…”