Adhesive tablet effective for treating canker sores in humans

Mizrahi, Boaz; Golenser, Jacob; Wolnerman, Joseph S.; Domb, Abraham J.

doi:10.1002/jps.20193

Cited by 22 publications

(15 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It must primarily have bioadhesive properties to ensure that it is retained in the mouth for the required period of time. (Mizrahi et al 2004) Mucoadhesion is influenced by drug and added excipient and concentration of polymeric compounds. Increase in the concentration of polymeric components significantly enhances formulation compressibility, adhesiveness, mucoadhesion and syringibility.…”

Section: Prerequisites Of Mucoadhesivesmentioning

confidence: 99%

Mucoadhesive systems in dentistry: A review

Rath¹,

Tevatia²,

Rath³

et al. 2016

IJDR

View full text Add to dashboard Cite

For any treatment plan to succeed, two factors are paramount correct selection and application of pharmacologic agents and patient compliance. But what happens when both these are followed judiciously, but the medicine itself does not stay long enough to finish its action? Then we need something that will make the medicine stick literally. That is when bioadhesives have their say. Long-term adhesion of drugs to the oral mucosa is usually prevented by the continuous salivary flow and the mechanical movements of the tongue. Therefore, formulations acting as vehicle for local drug delivery to the oral mucosa need to have excellent mucoadhesive properties. The present article reviews mucoadhesive systems with various formulations that can be used in dentistry to improve local drug delivery.

show abstract

Section: Prerequisites Of Mucoadhesivesmentioning

confidence: 99%

Mucoadhesive systems in dentistry: A review

Rath¹,

Tevatia²,

Rath³

et al. 2016

IJDR

View full text Add to dashboard Cite

show abstract

“…Adhesive tablets were prepared by compression molding of mixed powders of crosslinked polyacrylic acid and HPC, absorbed with citrus oil and magnesium salt. Tablets adhere well to the mucosal tissue and gradually erode for 8 h releasing the citrus oil whereas the magnesium is released during a period of 2 h. Both experimental and plain tablets were effective in reducing pain and decreasing healing time without adverse side effects, and the tablets loaded with active agents were more effective [132]. Figure 5 shows a male who had recurrent aphthous stomatitis, with a 7 mm diameter canker sore in the left lip before, during, and after treatment with the mucoadhesive tablet.…”

Section: Hydroxypropyl Cellulosementioning

confidence: 99%

Pharmaceutical significance of cellulose: A review

Kamel¹,

Ali²,

Jahangir³

et al. 2008

Express Polym. Lett.

375

191

View full text Add to dashboard Cite

Abstract. The amalgamation of polymer and pharmaceutical sciences led to the introduction of polymer in the design and development of drug delivery systems. Polymeric delivery systems are mainly intended to achieve controlled or sustained drug delivery. Polysaccharides fabricated into hydrophilic matrices remain popular biomaterials for controlled-release dosage forms and the most abundant naturally occurring biopolymer is cellulose; so hdroxypropylmethyl cellulose, hydroxypropyl cellulose, microcrystalline cellulose and hydroxyethyl cellulose can be used for production of time controlled delivery systems. Additionally microcrystalline cellulose, sodium carboxymethyl cellulose, hydroxypropylmethyl cellulose, hydroxyethyl cellulose as well as hydroxypropyl cellulose are used to coat tablets. Cellulose acetate phthalate and hydroxymethyl cellulose phthalate are also used for enteric coating of tablets. Targeting of drugs to the colon following oral administration has also been accomplished by using polysaccharides such as hdroxypropylmethyl cellulose and hydroxypropyl cellulose in hydrated form; also they act as binders that swell when hydrated by gastric media and delay absorption. This paper assembles the current knowledge on the structure and chemistry of cellulose, and in the development of innovative cellulose esters and ethers for pharmaceuticals.

show abstract

“…They can be found in drug delivery systems (12), mucoadhesive forms (13), synthesis of nanoparticles by the sol-gel method (14), and in ophthalmic and vaginal preparations (15), to name a few of their diverse applications. Eudragit® L 100 and Eudragit® S 100 are anionic copolymers based on methacrylic acid and methyl methacrylate.…”

Section: Introductionmentioning

confidence: 99%

Anhydride Prodrug of Ibuprofen and Acrylic Polymers

Mizrahi

Domb

2009

AAPS PharmSciTech

Self Cite

View full text Add to dashboard Cite

Abstract. The objective of this study was to synthesize anhydride prodrugs for carboxylic-acid-bearing agents such as non-steroidal anti-inflammatory drugs, shield the carboxylic acid group from irritative effects, and obtain sustained release patterns. Ibuprofen was used as a representative drug for anhydride derivatization. Conjugates of ibuprofen with carboxylic acid moieties of different acrylic polymers were prepared by dehydration reaction using acetic anhydride. Products were characterized by infrared spectroscopy, nuclear magnetic resonance, and scanning electron microscopy followed by preparation of microspheres with different sizes from the conjugate Eudragit® L-100-ibuprofen. The drug release was monitored by high-performance liquid chromatography. Ibuprofen was bound to the polymers via an anhydride bond in high reaction yields (75-95%) with drug loading of up to 30% (w/w). These anhydride derivatives hydrolyzed and release the drug at different periods ranging from 1 to 5 days, depending on the hydrophobicity and the cross-linking of the conjugates. The release of drug from the microspheres was correlated to their size and ranged from 2 to almost 8 days. This study demonstrates the promise of anhydride prodrug for extending drug action while shielding the carboxylic acid group.

show abstract

Adhesive tablet effective for treating canker sores in humans

Cited by 22 publications

References 32 publications

Mucoadhesive systems in dentistry: A review

Mucoadhesive systems in dentistry: A review

Pharmaceutical significance of cellulose: A review

Anhydride Prodrug of Ibuprofen and Acrylic Polymers

Contact Info

Product

Resources

About