Evaluation of effectiveness of concentrated growth factor on osseointegration

Pirpir, Çağaşan; Yilmaz, Onur; Çandırlı, Celal; Balaban, Emre

doi:10.1186/s40729-017-0069-3

Cited by 48 publications

(51 citation statements)

References 33 publications

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“…Histomorphometric analysis showed significantly higher mean percentage of new bone formation in group B (treated with CGF) at 66.939%, while mean percentage of new bone formation in group A (control group) was at 25.662% Student's t -test revealed that the difference between both groups was statistically significant (p=0.0001). this indicated accelerated bone formation in group B which comes in agreement with results reported by Honda etal 2013 (7) , Durmuslar etal 2016 (9) , Wang etal 2016 (10) , Pirpir etal 2017 (11) , Talaat etal 2018 ( 13) ; whom all found CGF to promote proliferation of osteoblasts and osteogenic maturation and mineralization which led to accelerated healing around the dental implant and further more implant stability and better surgical defect fill.…”

Section: Discussionsupporting

confidence: 87%

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Boosting Effect of Concentrated Growth Factor on Osseointegration of Immediate Implant: A Histological Analysis in Dogs

Moutamed

2019

Egyptian Dental Journal

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Background: Implant osseointegration is an important of long term success of the widely used Rehabilitation treatment. Many therapeutic presidiums have been investigated to accelerate osseointegration. Concentrated growth factors are third generation platelet concentrate used clinically in acceleration of tissue healing and bone regeneration. The aim of this study was to assess histologically the effect of using CGF on osseointegration of immediate dental implant in animal model Methods: ten animal models (adult mongrel dogs) were selected in this study each to receive one immediate implant of the Spectra system (Inc. Las Vegas, NV 89149, CA. USA). They were divided in to 2 equal groups; group A received immediate implant without CGF as a control group and group B received immediate implant with CGF which was applied to the socket walls before implant placement. Eight weeks postoperatively the animal models were euthanized and implants with surrounding bone were dissected and transferred in formalin to the lab for histologic preparation and histomorphometric analysis Results: histomorphometric analysis revealed the mean percentage of new bone formation for group A (control group) was 25.662 % while for group B it reached 66.939%. Student's t -test revealed that the difference between both groups was statistically significant difference with p value of 0.0001 which indicated the higher amount of bone regeneration in group B indicative of the accelerated osseointegration process in the test group.Conclusion it may be concluded that application of CGF to the socket walls before placement of immediate implant may enhance the healing of bone surrounding implants and accelerate osseointegration providing a convenient and affordable choice for implant placement. Application of this method may, therefore, be effective in enhancing the rate of osseointegration and allow for early loading of immediate implants.

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Section: Discussionsupporting

confidence: 87%

“…The authors concluded that the use of CGF method can replace the chondrocyte scaffold approach in cartilage regeneration. 11 Assessed the effect of CGF on implant stability and osseointegration in patients. The authors concluded that CGFs had positive effect on implant stabilization and accelerated osseointegration.…”

Section: Introductionmentioning

confidence: 99%

Boosting Effect of Concentrated Growth Factor on Osseointegration of Immediate Implant: A Histological Analysis in Dogs

Moutamed

2019

Egyptian Dental Journal

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“…16 As CGF was produced by alternate centrifugation, CGF contains abundant autologous growth factors that can promote cell proliferation, migration, osteogenic differentiation, and angiogenic properties in wound healing and bone regeneration. [17][18][19][20][21][22] Our recent studies revealed that CGF injection in hairless scalp could enhance the hair density and optimize the hairless appearance in AGA patients. 23 Therefore, we expanded on the results of previous studies by combining MXD with CGF and hypothesized that CGF intensifies the MXD efficacy to generate a more beneficial and stable HG effect on AGA.…”

Section: Introductionmentioning

confidence: 99%

Autologous Concentrated Growth Factors Combined with Topical Minoxidil for the Treatment of Male Androgenetic Alopecia: A Randomized Controlled Clinical Trial

Tan

Zhang

Xie

et al. 2021

Facial Plastic Surgery & Aesthetic Medicine

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Background: Minoxidil (MXD) is an U.S. Food and Drug Administration-approved drug for the topical treatment of androgenetic alopecia (AGA) with minor side effects, but its hair growth (HG) effect is unsatisfactory. Methods: A double-blinded within-subjects randomized clinical trial was conducted on 16 male AGA patients who showed limited improvement after MXD treatment. Eligible participants received three concentrated growth factor (CGF) injections on half of the scalp and the placebo on the other side at 4-week intervals, and MXD was applied twice daily on both sides throughout the follow-up period. The primary endpoint was the HG ratio at V4. The secondary endpoints included the HG ratios at V2, V3, and V5; hair density and T/V ratio at V2, V3, V4, and V5; Global Aesthetic Improvement Scale (GAIS) scores at V4 and V5; and participant satisfaction at V4. Results: Each group included 16 subjects; each half of the scalp was randomly assigned to the MXD+CGF or MXD group. The HG ratio at V4 was higher in the MXD+CGF group than in the MXD group. The MXD+CGF group had significant improvements in hair density, HG ratio, and T/V ratio compared with the MXD group over the follow-up period. The GAIS scores and participant satisfaction were higher in the MXD+CGF group than in the MXD group. Unexpectedly, the MXD+CGF treatment hastened HG, which was sustained for 3 months after discontinuation. No severe adverse events occurred. Conclusions: The combined treatment of MXD and CGF is safe and more efficient for AGA patients. Combining CGF can expedite the potency of MXD and provide patients with fast and lasting HG.

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“…PRF gained its popularity as a healing biomaterial for both soft and hard tissue because of the presence of various growth factors also it would facilitate tissue healing and regeneration by enhancing angiogenesis, chemotaxis, cell proliferation and differentiation and extracellular matrix synthesis [9,10] . For best outcomes in human tissue healing and regeneration, mutual interaction between a scaffold (fibrin matrix), platelets, growth factors, leukocytes, and stem cells are required [11,12] .…”

Section: Introductionmentioning

confidence: 99%

Clinical Evaluation of platelet rich fibrin versus subepithelial connective tissue graft, for soft tissue augmentation around implant in the aesthetic zone: A randomized control clinical trial.

Elbattawy

Kamal

Eiid

et al. 2020

Egyptian Dental Journal

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Background: the current study investigated platelet rich fibrin and subepithelial connective tissue graft in preserving crestal bone and soft tissue around delayed implants. Methods: Twelve participants with thin gingival biotype, were randomly assigned in two equal parallel groups. Both received delayed implant, augmented by subepithelial connective tissue graft versus platelet rich fibrin. Crestal bone level was measured at 3, 6 and 9 months. Gingival thickness and keratinized tissue width were measured at baseline, 3 and 6 months, pink esthetic score at 6 months, pain, swelling and patient satisfaction were reported after 7 days and at the end of the follow up period respectively. Results: Both groups showed statistically significant improvement in all clinical outcomes at 3 and 6 months with no statistically significant difference at different observational periods. Subepithelial connective tissue graft showed statistically significant increase in gingival thickness and pink esthetic score compared to platelet rich fibrin after 6 months with no statistically significant difference regarding the crestal bone loss, keratinized tissue width, postoperative pain, swelling and overall patient satisfaction between both groups. Conclusion: Inspite that PRF showed less values of crestal bone loss yet both treatment modalities could not prevent the postsurgical crestal bone loss to occur, with no statistically significant difference between them. Subepithelial connective tissue graft is effective at increasing the gingival thickness around delayed implants. Clinical relevance: Both treatment modalities could be used safely around dental implant. Subepithelial connective tissue graft is more effective in thin phenotype for augmenting gingival thickness.

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Evaluation of effectiveness of concentrated growth factor on osseointegration

Cited by 48 publications

References 33 publications

Boosting Effect of Concentrated Growth Factor on Osseointegration of Immediate Implant: A Histological Analysis in Dogs

Boosting Effect of Concentrated Growth Factor on Osseointegration of Immediate Implant: A Histological Analysis in Dogs

Autologous Concentrated Growth Factors Combined with Topical Minoxidil for the Treatment of Male Androgenetic Alopecia: A Randomized Controlled Clinical Trial

Clinical Evaluation of platelet rich fibrin versus subepithelial connective tissue graft, for soft tissue augmentation around implant in the aesthetic zone: A randomized control clinical trial.

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