Evaluation of Effect of Cyclosporine A on the Bone Tissue With Induced Periodontal Disease to Ligature in Rats

Nassar, Patrícia Oehlmeyer; Felipetti, Francielly Andressa; Nassar, Carlos Augusto; Spolidório, Luís Carlos

doi:10.1016/j.transproceed.2012.02.029

Cited by 7 publications

(6 citation statements)

References 10 publications

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“…However, in the current study only very few patients were found to present gingival overgrowth. Therefore, based on the clinical findings of the current study, an influence of Cyclosporine on periodontal destruction appears probable, what is contradictory to the recent investigations ( 22 , 23 ).…”

Section: Discussioncontrasting

confidence: 99%

“…Cyclosporine is well known to be associated with gingival overgrowth ( 2 , 21 ), what is in line with the current study’s findings, even though only eight patients showed gingival overgrowth. However, the influence on periodontal destruction is discussed controversially based on animal studies ( 22 , 23 ). The gingival overgrowth might explain higher PPD in patients with Cyclosporine.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association of time under immunosuppression and different immunosuppressive medication on periodontal parameters and selected bacteria of patients after solid organ transplantation

Schmalz¹,

Berisha²,

Wendorff³

et al. 2018

Med Oral

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BackgroundAim of this study was to investigate the association of the time under immunosuppression and different immunosuppressive medication on periodontal parameters and selected periodontal pathogenic bacteria of immunosuppressed patients after solid organ transplantation (SOT).Material and Methods169 Patients after SOT (lung, liver or kidney) were included and divided into subgroups according their time under (0-1, 1-3, 3-6, 6-10 and >10 years) and form of immunosuppression (Tacrolimus, Cyclosporine, Mycophenolate, Glucocorticoids, Sirolimus and monotherapy vs. combination). Periodontal probing depth (PPD) and clinical attachment loss (CAL) were assessed. Periodontal disease severity was classified as healthy/mild, moderate or severe periodontitis. Subgingival biofilm samples were investigated for eleven selected potentially periodontal pathogenic bacteria using polymerasechainreaction.ResultsThe mean PPD and CAL as well as prevalence of Treponema denticola and Capnocytophaga species was shown to be different but heterogeneous depending on time under immunosuppression (p<0.05). Furthermore, only the medication with Cyclosporine was found to show worse periodontal condition compared to patients without Cyclosporine (p<0.05). Prevalence of Porphyromonas gingivalis, Tannerella forsythia and Fusobacterium nucleatum was reduced and prevalence of Parvimonas micra and Capnocytophaga species was increased in patients under immunosuppression with Glucocorticoids, Mycophenolate as well as combination therapy.ConclusionsTime under and form of immunosuppression might have an impact on the clinical periodontal and microbiological parameters of patients after SOT. Patients under Cyclosporine medication should receive increased attention. Differences in subgingival biofilm, but not in clinical parameters were found for Glucocorticoids, Mycophenolate and combination therapy, making the clinical relevance of this finding unclear. Key words:Immunosuppression, organ transplantation, periodontitis, periodontal bacteria.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association of time under immunosuppression and different immunosuppressive medication on periodontal parameters and selected bacteria of patients after solid organ transplantation

Schmalz¹,

Berisha²,

Wendorff³

et al. 2018

Med Oral

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show abstract

“…However, Abdelhadi et al (2002), who administered our same dose to growing rats, did not find variations in the trabecular volume of tibial metaphysis, but they did find a decrease when administering 30 mg/kg/day. Nassar et al (2013) observed an imbalance of the alveolar bone homeostasia in a model of experimental periodontitis after the administration of 10 mg/kg of CsA over 30 days. All the studies that show undesirable effects on the bone of rats by CsA use high doses of CsA that could be considered toxic.…”

Section: Discussionmentioning

confidence: 93%

Sirolimus and tacrolimus rather than cyclosporine A cause bone loss in healthy adult male rats

Rubert

Montero

Guede³

et al. 2015

Bone Reports

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The aim of this work was to study the effects of cyclosporine (CsA), tacrolimus (FK-506), and rapamycin (RAPA) on bone mass, femoral microstructure, femoral biomechanical properties, and bone remodeling in healthy adult male rats.Forty-eight 5-month-old male Wistar rats were used. CsA (2 mg/kg/day), FK-506 (3 mg/kg/day), RAPA (1.25 mg/kg/day), or water (0.5 ml/rat/day, control group) were administered orally for 3 months.After sacrifice, mean values of immunosuppressants in blood were: CsA (670.4 ng/ml), FK-506 (19.2 ng/ml), and RAPA (4.8 ng/ml). Levels of biochemical parameters were normal in all groups. Femoral BMD was decreased in FK-506 and RAPA groups and lumbar BMD in FK-506 group. Trabecular volume fraction (BV/TV) decreased only in FK-506 group. RAPA and CsA affected femoral cortical structure, but FK-506 did not. FK-506 produced an increase in bone remodeling, and CsA a decrease. FK-506 group showed a decrease in biomechanical parameters relative to all groups. RAPA group showed a decrease in ultimate stress vs control group, and CsA group presented an increase in biomechanical parameters versus control group.We found that administration of both RAPA and FK-506 as monotherapy for healthy rats produced osteopenia. CsA treatment only produces slight damages in the cortical zone of the femur.

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“…13 In a 2013 study, Nassar et al Induced periodontitis in 3 groups of rats' teeth, finding that a combination of cyclosporine and periodontitis resulted in the most breakdown in the bone height among all 3 groups, and they concluded that cyclosporine interferes and intensifies the imbalance of alveolar bone ridge remodeling in rats. 14 Following analyses in vitro, other animal studies have reported that corticosteroids induced bone resorption. 15 A human cross-sectional study evaluating the long-term effects of inhaled corticosteroids reported that corticosteroids might reduce bone remodeling, causing a decrease in bone mineral density.…”

Section: Introductionmentioning

confidence: 99%

Is there a relationship between periodontal conditions and number of medications among the elderly?

Natto¹,

Aladmawy²,

Alshaeri³

et al. 2016

Ghana Medical Journal

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SUMMARYObjective: To investigate possible correlations of clinical attachment level and pocket depth with number of medications in elderly individuals. Methods: Intra-oral examinations for 139 patients visiting Tufts dental clinic were done. Periodontal assessments were performed with a manual UNC-15 periodontal probe to measure probing depth (PD) and clinical attachment level (CAL) at 6 sites. Complete lists of patients' medications were obtained during the examinations. Statistical analysis involved Kruskal-Wallis, chi square and multivariate logistic regression analyses. Results: Age and health status attained statistical significance (p< 0.05), in contingency table analysis with number of medications. Number of medications had an effect on CAL: increased attachment loss was observed when 4 or more medications were being taken by the patient. Number of medications did not have any effect on periodontal PD. In multivariate logistic regression analysis, 6 or more medications had a higher risk of attachment loss (>3mm) when compared to the no-medication group, in crude OR (1.20, 95% CI:0.22-6.64), and age adjusted (OR=1.16, 95% CI:0.21-6.45), but not with the multivariate model (OR=0.71, 95% CI:0.11-4.39). Conclusion: CAL seems to be more sensitive to the number of medications taken, when compared to PD. However, it is not possible to discriminate at exactly what number of drug combinations the breakdown in CAL will happen. We need to do further analysis, including more subjects, to understand the possible synergistic mechanisms for different drug and periodontal responses.

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Evaluation of Effect of Cyclosporine A on the Bone Tissue With Induced Periodontal Disease to Ligature in Rats

Cited by 7 publications

References 10 publications

Association of time under immunosuppression and different immunosuppressive medication on periodontal parameters and selected bacteria of patients after solid organ transplantation

Association of time under immunosuppression and different immunosuppressive medication on periodontal parameters and selected bacteria of patients after solid organ transplantation

Sirolimus and tacrolimus rather than cyclosporine A cause bone loss in healthy adult male rats

Is there a relationship between periodontal conditions and number of medications among the elderly?

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