2007
DOI: 10.1590/s1415-47572007000300026
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Abstract: We analyzed the consequences of aerial spraying with glyphosate added to a surfactant solution in the northern part of Ecuador. A total of 24 exposed and 21 unexposed control individuals were investigated using the comet assay. The results showed a higher degree of DNA damage in the exposed group (comet length = 35.5 μm) compared to the control group (comet length = 25.94 μm). These results suggest that in the formulation used during aerial spraying glyphosate had a genotoxic effect on the exposed individuals.

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Cited by 59 publications
(50 citation statements)
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References 24 publications
(25 reference statements)
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“…Beyond the standard genetic toxicity assays, IARC concluded for humans exposed to GBFs that there was positive evidence of DNA breakage as determined using the comet assay (Paz-y-Miño et al 2007), negative induction of chromosomal aberrations (Paz-y-Miño et al 2011), and positive induction of MN (Bolognesi et al 2009). These papers were critically reviewed by the Expert Panel and were found to be deficient as evidence for GBF genetic effects for many reasons (e.g.…”
Section: Genetic Toxicity and Oxidative Stress Datamentioning
confidence: 99%
“…Beyond the standard genetic toxicity assays, IARC concluded for humans exposed to GBFs that there was positive evidence of DNA breakage as determined using the comet assay (Paz-y-Miño et al 2007), negative induction of chromosomal aberrations (Paz-y-Miño et al 2011), and positive induction of MN (Bolognesi et al 2009). These papers were critically reviewed by the Expert Panel and were found to be deficient as evidence for GBF genetic effects for many reasons (e.g.…”
Section: Genetic Toxicity and Oxidative Stress Datamentioning
confidence: 99%
“…Also in different in vivo experiments, positive results were obtained in SCGE experiments, for example in amphibians (Clements et al 1997), reptiles (Poletta et al 2009), fish (Cavas and Konen 2007;Guilherme et al 2010), and plants (Alvarez-Moya et al 2011). Few years ago, the first article was published by Paz-y-Miño et al (2007) in which a significant increase of comet formation in peripheral lymphocytes of humans exposed to G via spraying was reported.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, it was found in field studies that contact of agricultural workers due to spraying leads to induction of micronuclei (MNi) that are formed as a consequence of structural and numerical chromosomal aberrations and to comet formation in peripheral lymphocytes (Bolognesi et al 2009;Paz-y-Miño et al 2007). Also in the course of the production of the pesticide, humans may come into dermal and/or inhalative contact with the herbicide, but no data are available from biomonitoring studies in which DNA damage was measured in exposed factory workers.…”
Section: Introductionmentioning
confidence: 99%
“…La técnica del ensayo cometa es un método relativamente rápido y simple para la detección del daño de ADN in vivo (17,18), debido a la exposición de factores como rayos X, pesticidas, hidrocarburos (17,19,20). La prueba consiste en someter los leucocitos sanguíneos a un campo eléctrico.…”
Section: Análisis Genético Ensayo Cometa -Electroforesis En Gel Alcalunclassified
“…Las muestras fueron analizadas por medio de la técnica descrita por Singh y colaboradores (17) con implementaciones realizadas en otras investigaciones (20,21). Las placas fueron analizadas usando un microscopio de fluorescencia con una lámpara de mercurio y un filtro de 515-560nm de excitación.…”
Section: Análisis Genético Ensayo Cometa -Electroforesis En Gel Alcalunclassified