Abstract:The dissolution proˆles of paliperidone from INVEGA3-mg tablets, osmotic-controlled release tablets, were evaluated by using the reciprocating cylinder method (RC method). We used 4 diŠerent compositions of the dissolution ‰uids, by considering the environment of the tablet in the gastrointestinal tract. After a lag time of 2 to 4 h, paliperidone was approximately dissolved to 24 h by zero-order release. The dissolution characteristics of paliperidone were not aŠected by the kind of the test medium, pH, and s… Show more
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