Evaluation of Dis-Lub-Tout, a new co-processed tabletting excipient I. Study of physicochemical properties

Study of the tableting properties of MCR, a newly co-processed cellulose based direct compression excipient

“…Rojas et al 15 found that RC has strong disintegration activity. Due to its large specific surface area, RC was successfully employed with olive oil to produce Dis-Lub-Tout, a newly co-processed tablet excipient of bi-functional activity 16,17 .…”

“…The IR spectra of authentic MCC sample and samples of CMCC and CRC powders were run using the technique described by Rojas et al 21 diameters of CMCC and MZ particles were determined by sieving technique using a set of stainless steel sieves (Fritsch, GmbH, FRG) arranged in descending order as described early 16 . The effective mean diameter of CRC particles was determined using a size analyzer (Brookhaven Instruments Corp., 750 Blue Point Holtsville, NY11742, USA) equipped with default particle sizing software program (ver.…”

“…The apparent density, ρ, of a given powder was determined using the liquid displacement technique. The bulk, ρB, and tap, ρT, densities and packing fraction, ρƒ, were determined using the early reported techniques 16 , respectively. The mean of five determinations of each experiment was calculated and taken as the determined value.…”

“…The mean of five determinations of each experiment was calculated and taken as the determined value. The moisture content (dry weight basis) was determined by drying technique as described earlier 16 .…”

“…Swelling index (SI) and hydration capacity (HC) determinations SI of a given cellulose powder was determined as follows 16 The IR spectrum run showed that the produced granules were alcohol free. The produced granules were compressed into large slugs using a single punch tableting machine (F3, Manesty Machines Ltd., Liverpool, UK).…”