Evaluation of Dis-Lub-Tout, a new co-processed tabletting excipient II. Lubricant property

Study of the Tableting Properties of MCR, a Newly Coprocessed Cellulose-based Direct Compression Excipient

“…Tablets were compressed using a Manesty single punch tableting machine fitted to flat faced punches adopting the modified compression technique. 17 The machine was adjusted to compress tablets of 250±0.05 mg mean weight, 9.0±0.02 mm mean diameter, and of the highest crushing strength, H, and lowest friability, F, levels that could be achieved from the batch formulated with 75% w/w (the highest concentration) of a given excipient. The machine settings were kept constant throughout compressing the rest of the batches formulated with the lower concentration of the given excipient.…”

“…Due to its large specific surface area, RC was successfully employed with olive oil to produce Dis-Lub-Tout, a newly coprocessed tablet excipient of bifunctional activity. 16,17 Metronidazole (MZ) is an antimicrobial agent effective against anaerobic bacteria and protozoa. It is primarily used to treat bacterial vaginosis, pelvic inflammatory disease, wounds, intraabdominal infections, trichomoniasis, and infections caused by susceptible anaerobic organisms.…”

Study of the tableting properties of MCR, a newly co-processed cellulose based direct compression excipient

“…Rojas et al 15 found that RC has strong disintegration activity. Due to its large specific surface area, RC was successfully employed with olive oil to produce Dis-Lub-Tout, a newly co-processed tablet excipient of bi-functional activity 16,17 .…”