Evaluation of dika wax-soybean oil-based artesunate-loaded lipospheres:<i>in vitro–in vivo</i>correlation studies

Chinaeke, E.E.; Chime, Salome Amarachi; Ogbonna, John Dike; Attama, Anthony A.; Müller‐Goymann, Christel C.; Okore, V. C.

doi:10.3109/02652048.2014.940008

Cited by 10 publications

(7 citation statements)

References 33 publications

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“…Therefore, multidisciplinary efforts are necessary to precisely evaluate the efficacy, bioavailability, and pharmacokinetics of these multipurpose systems, considering that there is a lack of animal models for testing different DDS for specific applications [144]. In general, we observed advantages of such hybrid systems over their respective traditional DDS, which significantly improved the in vivo pharmacokinetics and the activity of several classes of drugs [67,72,100,104,118,119,128]. As in the case of protein nanoparticles, where polymer-protein conjugates for gene delivery provided biofunctionality to the systems [57], other formulations reduced in vivo tumor growth [56]; and the anti-inflammatory activity five times higher than the traditional protein nanoparticle was noticed [58].…”

Section: In Vivo Performance Of Biohybrid Polymer-based Hybrid Ddsmentioning

confidence: 76%

“…A promising hybridbased lipid nanocapsule was described for the treatment of lung cancer, which described the in vivo (mice) tumor regression profile [110]. In vivo pharmacokinetics studies in rats demonstrated higher bioavailability of hybrid artesunateloaded lipospheres when compared to the commercial tablet for malaria treatment [104]. Different in vivo studies were described for SLN-and NLC-based hybrid systems for topical and parenteral applications, using mice, rat, and rabbit, as well as in human clinical trial, which demonstrated the effectiveness, nontoxicity, and bioavailability of these biodevices compared to their respective traditional DDS or free drug [86,88,94,96].…”

Section: In Vivo Performance Of Biohybrid Polymer-based Hybrid Ddsmentioning

confidence: 99%

“…Their advantages over other DDS (emulsions, liposomes, and polymer nanoparticles) include physical stability, being easy to disperse in aqueous medium, simple preparation, high retention of hydrophobic drugs in the core, and prolonged delivery [102]. Lipospheres have been used for the delivery of several classes of drugs, such as local anesthetics [99], anti-inflammatories [100], antineoplastic [101], immunosuppressant [102], hypoglycemic agents [103], antimalarial agents [104], and antihypertensive agents [105].…”

Section: Innovative Hybrid Lipid Nanoparticles: Solid Lipid Nanopartimentioning

confidence: 99%

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Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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The use of biomaterials composed of organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery. Drug delivery systems (DDS) have shown several advantages over traditional drug therapy, such as greater therapeutic efficacy, prolonged delivery profile, and reduced drug toxicity, as evidenced by in vitro and in vivo studies as well as clinical trials. Despite that, there is no perfect delivery carrier, and issues such as undesirable viscosity and physicochemical stability or inability to efficiently encapsulate hydrophilic/hydrophobic molecules still persist, limiting DDS applications. To overcome that, biohybrid systems, originating from the synergistic assembly of polymers and other organic materials such as proteins and lipids, have recently been described, yielding molecularly planned biohybrid systems that are able to optimize structures to easily interact with the targets. This work revised the biohybrid DDS clarifying their advantages, limitations, and future perspectives in an attempt to contribute to further research of innovative and safe biohybrid polymer-based system as biomaterials for the sustained release of active molecules.

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Section: In Vivo Performance Of Biohybrid Polymer-based Hybrid Ddsmentioning

confidence: 76%

Section: In Vivo Performance Of Biohybrid Polymer-based Hybrid Ddsmentioning

confidence: 99%

Section: Innovative Hybrid Lipid Nanoparticles: Solid Lipid Nanopartimentioning

confidence: 99%

See 1 more Smart Citation

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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“…Chinaeke et al examined the in vitro-in vivo correlation of wax-soybean oil-based artesunate-loaded lipospheres. It was revealed that the formulated lipospheres had maximum encapsulation efficiency of 80%, with a bioavailability enhancement factor of 2.108 when compared with tablets [151]. These studies show the potential of improved efficacy if phytochemicals are formulated as nanolipid systems.…”

Section: Lipid Nanoparticlesmentioning

confidence: 74%

Exploring Nanotechnologies for the Effective Therapy of Malaria Using Plant-Based Medicines

Oga¹,

Singh

2016

CPD

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Malaria is a potentially lethal disease caused by species of the plasmodium parasite. Despite the advances in the interventions for its control and approaches to manage fatality, morbidity and mortality rates associated with malaria are still high. At present, artemisinin-based combination therapy is the first line of treatment. However, there is the need to explore newer approaches as reduced effectiveness and multi-drug resistance (even to artemisinin) has been reported in some regions and is expected to widen in scope. Phytomedicines have shown promise for the management of this debilitating disease and there are abundant resources in most of the areas where this disease is endemic. This report would systematically review the literature, emphasizing the challenges encountered in the control of malaria, active phytochemicals currently utilised in the management, drug delivery approaches as well as the nanotechnology-based systems that could be exploited in its treatment. These phytomedicines, either delivered conventionally or via the use of advanced delivery systems may suggest new strategies towards the better management of malaria.

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“…These microcapsule matrices protect the loaded labile substances against degradation and can defend the GIT mucosa from severe irritations of various drugs as well as conceivably offer sustained drug discharge and drug targeting [10]. Many research works on Artemether loaded microcapsules has been formulated and assessed for in vivo performance in malariogenic mice [11,12].…”

Section: Introductionmentioning

confidence: 99%

Formulation and characterization of artemether-loaded sodium alginate microcapsules

Nnamani¹,

Echezona²,

Metu³

et al. 2020

Trop. J. Pharm Res

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Purpose: To increase the solubility of artemether (ART) in Transcutol® HP through microencapsulation in sodium alginate polymer to achieve sustained in vivo release.Method: Graded concentrations of ART (0.00, 0.25, 0.50, 0.75, and 1.00 g) microcapsules were produced using Tween® 80 by the cold homogenization method at 24 x 1000 rpm for 15 min. Characterization based on yield, encapsulation efficiency (EE), particle size, pH stability, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and in vivo release using Peter’s four-day suppressive protocol in Wistar mice infected with Plasmodium berghei, were determined.Results: The results obtained indicate that 0.5 g ART-loaded microcapsules (AMC) showed the highest yield of 96.85 %. The EE of 88.3 % corresponded to 0.75 g ART-loaded microcapsules. DSC results revealed that there was a significant reduction in enthalpy in all the formulations compared to the crystalline drug, but no strong bond interaction occurred except for the blank microcapsules. The AMC1.0 showed high dose-dependent plasmodial growth inhibition of 88.75 % while AMC0.25 had the least (68.13 %).Conclusion: The artemether microcapsules showed sustained release characteristics for oral delivery of artemether and therefore may reduce some of the adverse effects associated with high dose artemether therapy in conventional oral tablets. Keywords: Malaria, Artemether, Transcutol® HP, Sustained-release, RBC count, Antiplasmodial activity

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Evaluation of dika wax-soybean oil-based artesunate-loaded lipospheres:in vitro–in vivocorrelation studies

Abstract: Artesunate-loaded lipospheres could be used orally or parenterally once daily, for the treatment of malaria.

Cited by 10 publications

References 33 publications

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Exploring Nanotechnologies for the Effective Therapy of Malaria Using Plant-Based Medicines

Formulation and characterization of artemether-loaded sodium alginate microcapsules

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