Evaluation of dietary factors in relation to the biomarkers of oxidative stress and inflammation in breast cancer risk

Yeon, Jee-Young; Suh, Yelin; Kim, Sang–Wook; Baik, Hyun Wook; Sung, Chung-Ja; Kim, Hyun‐Sook; Sung, Mi‐Kyung

doi:10.1016/j.nut.2010.10.012

Cited by 45 publications

(43 citation statements)

References 50 publications

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“…Weight loss reduces enhanced oxidative stress and different methods, such as physical activity, caloric restriction, and surgical intervention, have been proposed to combat free radicals and reduce adipose tissue (Vincent and Taylor, 2006). Regarding antioxidant supplementation, Yeon et al (2011) have shown that the plasma total antioxidant capacity significantly increases as the quartile value of dietary fiber and antioxidant vitamins, such as vitamin A, β-carotene, vitamin C, and vitamin E increases, whereas 8-OHdG level is negatively associated with vitamin A and β-carotene intake. Both mechanisms (weight loss and dietary antioxidants) have been reported to induce changes in epigenetic marks (Bouchard et al, 2010;Chung et al, 2010).…”

Section: Oxidative Stressmentioning

confidence: 99%

Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

Milagro

Mansego

Miguel

et al. 2013

Molecular Aspects of Medicine

252

161

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Nutritional factors play a life-long role in human health. Indeed, there is growing evidence that one of the mechanisms by which nutrients and bioactive compounds affect metabolic traits is epigenetics. Complex interactions among food components and histone modifications, DNA methylation, non-coding RNA expression and chromatin remodeling factors lead to a dynamic regulation of gene expression that controls the cellular phenotype. Although perinatal period is the time of highest phenotypic plasticity, contributing largely to developmental programming, also during adulthood there is evidence about a nutritional influence on epigenetic regulation. Similarly to type 2 diabetes, hypertension, atherosclerosis and other metabolic disorders, obesity predisposition and weight loss outcomes have been repeatedly associated to changes in epigenetic patterns. Different non-nutritional risk factors that usually accompany obesity seem also to be involved in these epigenetic modifications, especially hyperglycemia, inflammation, hypoxia and oxidative stress. There are currently three major objectives in epigenetic research in relation to obesity: to search for epigenetic biomarkers to predict future health problems or detect the individuals at most risk, to understand the obesity-related environmental factors that could modulate gene expression by affecting epigenetic mechanisms, and to study novel therapeutic strategies based on nutritional or pharmacological agents that can modify epigenetic marks. At this level, the major tasks are: development of robust epigenetic biomarkers of weight regulation, description of those epigenetic marks more susceptible to be modified by dietary exposures, identification of the active ingredients (and the doses) that alter the epigenome, assessment of the real importance of other obesity-related factors on epigenetic regulation, determination of the period of life in which best results are obtained, and understanding of the importance of the inheritance of these epigenetic marks.

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Section: Oxidative Stressmentioning

confidence: 99%

Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

Milagro

Mansego

Miguel

et al. 2013

Molecular Aspects of Medicine

252

161

View full text Add to dashboard Cite

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“…Oxidative stress and antioxidative status are considered important elements in the development of these late effects [3,4]. Some studies have indicated a favorable influence of diet with antioxidant supplementation on the reduction in the toxic effect of ROS-generating chemotherapies, as well as on a reduced risk of cancer development or recurrence [5,[17][18][19]. There have been few studies concerning oxidative stress and/or the antioxidant status in children during and after anticancer treatment.…”

Section: Discussionmentioning

confidence: 99%

Total antioxidant status (TAS) in childhood cancer survivors

Krawczuk‐Rybak¹,

Panasiuk²,

Czygier³

et al. 2012

Folia Histochem Cytobiol.

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Abstract:Total antioxidant status (TAS), and the influence of treatment and correlation between TAS and parameters involved in metabolic syndrome (MS) in pediatric cancer survivors were evaluated. One hundred children and adolescents were studied. Twenty-five survivors received radiotherapy, 12 were obese or overweight. Additionally, we analyzed TAS in eight children with acute lymphoblastic leukemia (ALL) at diagnosis and during treatment after remission induction. The control group consisted of 22 healthy children. Serum concentrations of TAS, glucose, cholesterol, HDL-cholesterol, triglycerides, fibrinogen and insulin were measured. In cancer survivors, independently of diagnosis and kind of treatment (radiotherapy anthracyclines administration), the mean serum TAS did not differ significantly from the control group. No correlations were observed with age at the time of diagnosis or interval after the end of treatment. TAS values did not correlate with traits of the metabolic syndrome. In a group of eight patients with ALL at diagnosis and after induction of remission, TAS values were lower than in the control and cancer survivor groups. Antioxidant status was not found to be deteriorated in children after anticancer treatment, irrespective of diagnosis or kind of treatment, which might indicate sufficient antioxidant prevention. However, the possibility of the development of MS and cardiovascular disease in adulthood indicates the need for future studies.

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“…However, some studies do not confirm an association between IGF factors and LC risk (Ahn et al, 2006;Renehan et al, 2004). Strong and coherent evidence exists for the role of increased oxidative stress in carcinogenesis (Filaire et al, 2013;Klaunig et al, 2010;Kruk, Duchnik, 2014;Laszlo et al, 2014;Manda, Nechifor, Neagu, 2009;Valluru, Dasari, Wudayagiri, 2014;Yeon et al, 2011). Smoking and environmental carcinogenic inhalations are examples of exogenous sources of ROS and nitrogen species.…”

Section: Physical Activity and Lung Cancer Riskmentioning

confidence: 99%

The Associations of Selected Lifestyle Patterns and Lung Cancer Risk: An Evidence-based Update

Aboul‐Enein

Kruk

2016

Central European Journal of Sport Sciences and Medicine

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Abstract. Diagnosis of lung cancer (LC) has been fraught with difficulty and by the time of definitive diagnosis, most patients are in later stages of the disease. Epidemiological studies have demonstrated that lifestyle behaviors play an etiological role in LC risk; however data in the literature on this topic often appears inconclusive or require further study. Understanding of the mechanisms operating between lifestyle patterns and their impact on LC is important for the disease's prevention and treatment. The purpose of this study was to review the current evidence on the role of diet, body mass index (BMI), physical activity, smoking, alcohol consumption, and sex hormone use in LC development based on meta-analyses, systematic reviews and previously published epidemiologic studies. Regarded as the foremost cause of LC, evidence from studies have indicated that tobacco smoking causes LC. Additionally, exposure to outdoor air pollution and/or occupational-related exposures increase LC risk. Further, frequent consumption of red meat, processed meat increases adenocarcinoma and squamous cell carcinoma. Inverse associations between the disease risk and BMI ≥25 kg/m 2 , higher level of physical activity, and fruit and vegetable consumption with a high frequency were reported. Future studies are warranted to validate the association between histologic subtypes of LC and lifestyle patterns.

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Evaluation of dietary factors in relation to the biomarkers of oxidative stress and inflammation in breast cancer risk

Cited by 45 publications

References 50 publications

Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

Total antioxidant status (TAS) in childhood cancer survivors

The Associations of Selected Lifestyle Patterns and Lung Cancer Risk: An Evidence-based Update

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