The purpose of this study was to show that some elements have a proven
antioxidative effect and are essential for the proper development and
functioning of the human body. The study also assessed the concentration of
selected elements and total antioxidant status (TAS) in a group of male
inhabitants of Białystok, Poland, who are professionally active in the metal
industry. The study group comprised 163 men aged 55–64 years. The concentration
of the analyzed elements was determined using flame (Zn and Cu) and
electrothermal (Se, Cd, and Pb) atomic absorption spectrometry.
Spectrophotometric test kits were used to assay the TAS and glutathione
reductase (GR) activity in serum. The results suggested the mean concentration
of Se in serum was 54.04 ± 12.10 μg/L, which was below the reference range. A
significant negative correlation was observed between the concentration of Se in
the serum and Pb and Cd concentrations in the whole blood of the studied men.
The concentrations of the other elements, antioxidant potential, and GR activity
were within the reference range. A statistically significant positive
correlation was observed between Pb and Cd, indicating combined exposure and a
considerable negative correlation between lead and selenium as well as between
lead and TAS. Selenium and TAS are likely to modify the adverse effects of Pb in
the bodies of the studied men. The results indicate that it is necessary to
constantly monitor men who are occupationally exposed to heavy metals, maintain
a healthy lifestyle, and introduce effective preventive measures at a local
level.
Abstract:Total antioxidant status (TAS), and the influence of treatment and correlation between TAS and parameters involved in metabolic syndrome (MS) in pediatric cancer survivors were evaluated. One hundred children and adolescents were studied. Twenty-five survivors received radiotherapy, 12 were obese or overweight. Additionally, we analyzed TAS in eight children with acute lymphoblastic leukemia (ALL) at diagnosis and during treatment after remission induction. The control group consisted of 22 healthy children. Serum concentrations of TAS, glucose, cholesterol, HDL-cholesterol, triglycerides, fibrinogen and insulin were measured. In cancer survivors, independently of diagnosis and kind of treatment (radiotherapy anthracyclines administration), the mean serum TAS did not differ significantly from the control group. No correlations were observed with age at the time of diagnosis or interval after the end of treatment. TAS values did not correlate with traits of the metabolic syndrome. In a group of eight patients with ALL at diagnosis and after induction of remission, TAS values were lower than in the control and cancer survivor groups. Antioxidant status was not found to be deteriorated in children after anticancer treatment, irrespective of diagnosis or kind of treatment, which might indicate sufficient antioxidant prevention. However, the possibility of the development of MS and cardiovascular disease in adulthood indicates the need for future studies.
Abstract:Total antioxidant status (TAS), and the influence of treatment and correlation between TAS and parameters involved in metabolic syndrome (MS) in pediatric cancer survivors were evaluated. One hundred children and adolescents were studied. Twenty-five survivors received radiotherapy, 12 were obese or overweight. Additionally, we analyzed TAS in eight children with acute lymphoblastic leukemia (ALL) at diagnosis and during treatment after remission induction. The control group consisted of 22 healthy children. Serum concentrations of TAS, glucose, cholesterol, HDL-cholesterol, triglycerides, fibrinogen and insulin were measured. In cancer survivors, independently of diagnosis and kind of treatment (radiotherapy anthracyclines administration), the mean serum TAS did not differ significantly from the control group. No correlations were observed with age at the time of diagnosis or interval after the end of treatment. TAS values did not correlate with traits of the metabolic syndrome. In a group of eight patients with ALL at diagnosis and after induction of remission, TAS values were lower than in the control and cancer survivor groups. Antioxidant status was not found to be deteriorated in children after anticancer treatment, irrespective of diagnosis or kind of treatment, which might indicate sufficient antioxidant prevention. However, the possibility of the development of MS and cardiovascular disease in adulthood indicates the need for future studies.
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