Evaluation of Dexmedetomidine and Postoperative Pain Management in Patients With Adolescent Idiopathic Scoliosis

Jones, John S.; Cotugno, Richard E.; Singhal, Neil Raj; Soares, Neha; Semenova, Janet; Nebar, Sean; Parke, Emily J.; Shrader, M. Wade; Hotz, Jeffrey

doi:10.1097/pcc.0000000000000119

Cited by 24 publications

(22 citation statements)

References 20 publications

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“…The analgesic and opioid-sparing effect of DEX have been well described in previous studies, both in adult and children. 7 , 20 , 21 Similar to the present data, these studies reported significantly lower VAS, morphine consumption, and morphine demands. Together with these findings, the present study indicated that intraoperative administration of DEX is a potential way to be used to promote morphine-based PCA after abdominal surgery.…”

Section: Discussionsupporting

confidence: 90%

Intraoperative Dexmedetomidine Promotes Postoperative Analgesia and Recovery in Patients after Abdominal Colectomy

Tang

et al. 2015

Medicine

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Surgery-induced acute postoperative pain and stress response may lead to prolonged convalescence. The present study was designed to investigate the effects of intraoperative dexmedetomidine on postoperative analgesia and recovery after abdominal colectomy surgeries.Sixty-seven patients scheduled for abdominal colectomy under general anesthesia were divided into two groups, which were maintained using propofol/remifentanil/dexmedetomidine (PRD) or propofol/remifentanil/saline (PRS).During surgery, patients in the PRD group had a lower bispectral index value, which indicated a deeper anesthetic state and a higher sedation score right after extubation, than patients in the PRS group. During the first 24 hours after surgery, PRD patients consumed less morphine in patient-controlled analgesia, and had a lower score in visual analog scale, than their controls from the PRS group. The global 40-item quality of recovery questionnaire and 9-question fatigue severity score both showed a higher recovery score from day 3 after surgery in the PRD group.Intraoperative administration of dexmedetomidine seems to promote the analgesic property of morphine-based patient-controlled analgesia, and speed recovery from surgery in patients after abdominal colectomy.

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Section: Discussionsupporting

confidence: 90%

Intraoperative Dexmedetomidine Promotes Postoperative Analgesia and Recovery in Patients after Abdominal Colectomy

Tang

et al. 2015

Medicine

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“…Moreover, patients from the PRD group who received intraoperative dexmedetomidine had lower pump-press number, and consumed less morphine than those in the PRS group. The analgesic and opioid-sparing effects of dexmedetomidine have been well described in previous studies both in adults and children 7 16 17 . Similar to the present data, these studies reported significantly lower VAS scores and morphine consumption and fewer morphine demands.…”

Section: Discussionsupporting

confidence: 54%

Intraoperative Dexmedetomidine Promotes Postoperative Analgesia and Recovery in Patients after Abdominal Hysterectomy: a Double-Blind, Randomized Clinical Trial

Tang

et al. 2016

Sci Rep

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Surgery-induced acute postoperative pain and stress response can lead to prolonged convalescence. The present study was designed to investigate the effects of intraoperative dexmedetomidine on postoperative analgesia and recovery following abdominal hysterectomy surgeries. Sixty-four patients scheduled for abdominal hysterectomy under general anesthesia were divided into two groups that were maintained using propofol/remifentanil/dexmedetomidine (PRD) or propofol/remifentanil/saline (PRS). During surgery, patients in the PRD group had a lower bispectral index (BIS) value, which indicated a deeper anesthetic state, and a higher sedation score immediately after extubation than patients in the PRS group. During the first 24 hours post-surgery, PRD patients consumed less morphine with patient-controlled analgesia (PCA) and had lower scores on a visual analogue scale (VAS) than their controls from the PRS group. The global 40-item quality of recovery questionnaire and 9-question fatigue severity score both showed higher recovery scores from day 3 after surgery in the PRD group. with the data are considered together, intraoperative administration of dexmedetomidine appeared to promote the analgesic properties of morphine-based PCA and to expedite recovery following surgery in patients undergoing abdominal hysterectomy.

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“…It also had a potential to reduce postoperative nausea and vomiting. Morphine-sparing effect of dexmedetomine have also been well established by other early studies both in adults and pediatric patients (McQueen-Shadfar et al, 2011; Gupta et al, 2013; Jones et al, 2014). Recent clinical studies also reported that dexmedetomidine could be used to control postoperative analgesia and chronic pain in breast cancer patients following radical hamstectomy (Jain et al, 2012; Mohamed et al, 2014; Mohta et al, 2016).…”

Section: Discussionmentioning

confidence: 60%

Dexmedetomidine Improves Postoperative Patient-Controlled Analgesia following Radical Mastectomy

et al. 2017

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Acute postoperative pain following radical mastectomy is a high risk for prolonged convalescence and potential persistent pain in patients with breast cancer. The present study was designed to observe the effect of intraoperative use of dexmedetomidine on acute postoperative pain following radical mastectomy under general anesthesia. Forty-five patients were enrolled into the study and divided into two groups that were maintained with propofol/remifentanil/Ringer's solution or propofol/remifentanil/Dexmedetomidine followed by morphine-based patient-controlled analgesia. During the first 24 h following surgery, patients receiving dexmedetomine had lower NRS pain scores, decreased morphine consumption, longer time to first morphine request as well as a trending decreased incidence of adverse effects when compared to those received Ringer's solution. In conclusion, the present study finds that intraoperative use of dexmedetomidine could promote analgesic property of postoperative morphine.

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Evaluation of Dexmedetomidine and Postoperative Pain Management in Patients With Adolescent Idiopathic Scoliosis

Cited by 24 publications

References 20 publications

Intraoperative Dexmedetomidine Promotes Postoperative Analgesia and Recovery in Patients after Abdominal Colectomy

Intraoperative Dexmedetomidine Promotes Postoperative Analgesia and Recovery in Patients after Abdominal Colectomy

Intraoperative Dexmedetomidine Promotes Postoperative Analgesia and Recovery in Patients after Abdominal Hysterectomy: a Double-Blind, Randomized Clinical Trial

Dexmedetomidine Improves Postoperative Patient-Controlled Analgesia following Radical Mastectomy

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