Intraoperative Dexmedetomidine Promotes Postoperative Analgesia and Recovery in Patients after Abdominal Colectomy

Abstract

Surgery-induced acute postoperative pain and stress response may lead to prolonged convalescence. The present study was designed to investigate the effects of intraoperative dexmedetomidine on postoperative analgesia and recovery after abdominal colectomy surgeries.Sixty-seven patients scheduled for abdominal colectomy under general anesthesia were divided into two groups, which were maintained using propofol/remifentanil/dexmedetomidine (PRD) or propofol/remifentanil/saline (PRS).During surgery, patients in the PRD group had a lower bispectral index value, which indicated a deeper anesthetic state and a higher sedation score right after extubation, than patients in the PRS group. During the first 24 hours after surgery, PRD patients consumed less morphine in patient-controlled analgesia, and had a lower score in visual analog scale, than their controls from the PRS group. The global 40-item quality of recovery questionnaire and 9-question fatigue severity score both showed a higher recovery score from day 3 after surgery in the PRD group.Intraoperative administration of dexmedetomidine seems to promote the analgesic property of morphine-based patient-controlled analgesia, and speed recovery from surgery in patients after abdominal colectomy.

Effects of intraoperative dexmedetomidine with intravenous anesthesia on postoperative emergence agitation/delirium in pediatric patients undergoing tonsillectomy with or without adenoidectomy

“…Written informed consent for participation in this study was obtained from parents or guardians of all the participants before the start of the study. The sample size of the study was calculated according to the previous studies [11,9–21] and was based on a pilot study.…”

“…Dexmedetomidine (DEX), with its potent and specific affinity of α 2 -adrenergic receptors, [10] has properties of sedation, antianxiety, and analgesic effects, [11–15] and can reduce the incidence of POED in pediatric patients undergoing inhalation anesthesia. [11,12,14,16–18] However, the impact of DEX on the incidence of POED in pediatric patients after intravenous anesthesia is unknown. In the present study, we observed the safety of intraoperative combination of DEX with intravenous anesthesia in pediatric patients undergoing tonsillectomy with or without adenoidectomy, and validity for the prevention of POED.…”

Comparison of the morphine-sparing effect of intraoperative dexmedetomidine with and without loading dose following general anesthesia in multiple-fracture patients

“…[1] For example, recent clinical studies indicated that intraoperative administration of DEX shown potent proanalgesic effect on morphine-based PCA. [6–8] A recent study reported that a combination of DEX and sufentani as PCA displayed a significantly improved analgesic effect in patients following hysterectomy. [4] …”

“…Ramsay sedation score was evaluated as previous reports. [6–8] Rescue morphine in the postanesthesia care unit (PACU) was included in the total consumption of postoperative PCA morphine. Postoperative acute pain intensity was evaluated with visual analog scale (VAS).…”

Intravenous versus Ultrasound Guided Thoracic Paravertebral Morphine-Dexmedetomidine Combination in Patients with Multiple Rib Fractures

“…Dexmedetomidine, a medetomidine's dextrogyrous enantiomer [10], possess an opioid-sparing effect due to its high selective α 2 adrenoceptor agonist effect [11]. It has been recently proved that perioperative dexmedetomidine administration reduces postoperative morphine requirements even without loading dose [12][13][14][15][16]. Dexmedetomidine has a synergistic action with opioids [17].…”