Evaluation of Depth of Invasion and Tumor Thickness as a Prognostic Factor for Early-Stage Oral Squamous Cell Carcinoma: A Retrospective Study

Lee, You-Jung; Kwon, Tae-Geon; Kim, Jin-Wook; Lee, Sung-Tak; Hong, Sangjin; Choi, Sie−Young

doi:10.3390/diagnostics12010020

Cited by 6 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…New effective examination and imaging techniques are being developed that allow the surgeon to better visualize the boundaries of the primary tumor before and during the surgery more precisely [12][13][14][15][16][17][18][19][20][21][22][23][24]. With the help of these techniques, it is possible, among other things, to have a positive impact on margin surveillance.…”

Section: Introductionmentioning

confidence: 99%

Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery

Pošta,

Kolk,

Pivovarčíková

et al. 2023

Preprint

View full text Add to dashboard Cite

The influence of preoperative examination of oral squamous cell carcinoma (OSCC) mucosal surrounding by VELscope (Visually Enhanced Lesion Scope) on the radicality of surgical treatment of OSCC was the goal of this study.It is the first analysis of its kind with a total number of 122 patients suffering from OSCC with homogenous distribution of different tumor stages randomized into a study and a control group and enrolled in our study after meeting the inclusion criteria. The preoperative checkup by VELscope accompanied by the marking of the range of a loss of fluorescence in the study group was performed before the surgery. We have developed a unique mucosal tattoo marking technique for this purpose. The pathohistological results after surgical treatment, i.e. the margin status, were then compared. We achieved the pathological free margin (pFM) in 55 patients, the pathological close margin (pCM) in 6 cases and we encountered no case of the pathological positive margin (pPM) in the mucosal layer in the study group. In comparison, the control group results revealed pPM in 7 cases, pCM in 14 cases and pFM in 40 of all cases in the mucosal layer. This study proved that the preoperative autofluorescence evaluation of a tumor mucosal surrounding can enhance the ability to reach the pFM resection.

show abstract

Section: Introductionmentioning

confidence: 99%

Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery

Pošta,

Kolk,

Pivovarčíková

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Studies have shown that circular RNA (circRNA) is a kind of non-coding RNA, which has high stability due to its closed circular molecule ( Zheng et al, 2019 ). Studies have shown that circRNA can inhibit its expression by acting as a sponge molecule of microRNA (miRNA), thus regulating the biological processes of tumor cell proliferation, apoptosis, migration, and so on ( Lee et al, 2021 ). However, there are relatively few studies on circRNAs in oral squamous cell carcinoma.…”

Section: Introductionmentioning

confidence: 99%

CircPUM1 Knockdown Confers Radiosensitivity in Oral Squamous Cell Carcinoma by Regulating the miR-580/STAT3 Pathway

et al. 2022

View full text Add to dashboard Cite

Background: CircPUM1 acts as an oncogene in a variety of tumors, and there is no related research on oral squamous cell carcinoma. This study aimed to evaluate the clinical significance of CircPUM1 in oral squamous cell carcinoma radiotherapy.Methods: Radio-resistant cell lines were established by increasing the X-ray dose. Analysis of CircPUM1 expression in oral squamous cell carcinoma was carried out using bioinformatics tools. Cell proliferation was analyzed with CCK-8 and colony formation. Protein and gene expressions were detected by Western blotting and qPCR. RNA interference inhibits endogenous gene expression. A luciferase reporter system and immunoprecipitation were used to validate the target of CircPUM1.Result: CircPUM1 was highly expressed in OSCC. The higher the expression level of CircPUM1 in OSCC, the worse the clinical features and prognosis. Knockdown of CircPUM1 enhances the sensitivity of OSCC cells to X-rays, and expression of exogenous CircPUM1 makes OSCC cells acquire radiation resistance. The absence of CircPUM1 blocked the cells in the G0/G1 phase and triggered apoptosis. The prediction of mir-580-binding site, luciferase reporter system, and immunoprecipitation confirmed that mir-580 is the binding site of CircPUM1. In addition, STAT3 was predicted and confirmed as the binding site of mir-580. Overexpression of STAT3 partially attenuated the radiosensitivity of OSCC cells to knockdown of CircPUM1.Conclusion: CircPUM1 has the oncogene expression profile in oral squamous cell carcinoma; patients with high expression of CircPUM1 have less benefit from radiotherapy and need more frequent follow-up. In addition, CircPUM1 may be a potential therapeutic target for oral squamous cell carcinoma. The CircPUM1/mir-580/STAT3 axis has a certain effect on the radiosensitivity of OSCC. These results suggest that patients with low expression of CircPUM1 may gain more benefits.

show abstract

Depth of invasion analysis to predict acral melanoma outcomes

Asato,

Moares-Neto,

de Toledo Moraes

et al. 2024

Annals of Diagnostic Pathology

View full text Add to dashboard Cite

Evaluation of Depth of Invasion and Tumor Thickness as a Prognostic Factor for Early-Stage Oral Squamous Cell Carcinoma: A Retrospective Study

Cited by 6 publications

References 20 publications

Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery

Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery

CircPUM1 Knockdown Confers Radiosensitivity in Oral Squamous Cell Carcinoma by Regulating the miR-580/STAT3 Pathway

Depth of invasion analysis to predict acral melanoma outcomes

Contact Info

Product

Resources

About