Evaluation of Deltamethrin induced reproductive toxicity in male Swiss Albino mice

Desai, Ketaki R.; Moid, Nilofer; Patel, Piyush; Highland, Hyacinth

doi:10.1016/j.apjr.2015.12.004

Cited by 25 publications

(21 citation statements)

References 12 publications

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“…Cleber et al, (2017) suggested that accumulation of the insecticides in the testicular tissue may have adversely affected the sertoli cell population leading to compromised spermatogenesis and reduction in sperm head counts. Our results were in agreement with results reported by (Desai et al, 2016) who observed the adverse effect of low and high doses of DLM for 45 days on reproductive organs and fertility indices of male Albino mice. The author revealed that Decline in testicular weight might be due to declined serum testosterone concentration, decreased number of germ cells, inhibition of spermatogenesis and decline in steroidogenic enzyme activities.…”

Section: Discussionsupporting

confidence: 94%

Biochemical Role of Pyrethroids on Male Fertility and Seminal Profile of Rat

Maksoud

Mahfouz

Soliman

et al. 2018

Benha Veterinary Medical Journal

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A B S T R A C TA total number of 80 Wister male rats, 9 -wk. old were taken, weighed and divided into four experimental groups to investigate the effect of Deltamethrin (DLM) oral administration (0.87, 8.7 and 17.4 mg/kg B.W) for a period of 9 weeks on reproductive organs and fertility indices of Wister male rats. The results indicated that DLM caused a significant reduction in Testis weights, sperm count, motility and viability and fructose in semen. Also induced decreases in serum FSH, LH and Estradiol levels however increase in sperm abnormalities. These results indicated that DLM is a toxic pyrethroid pesticide that produced significant reproductive toxicity in treated male rats as revealed by the severely affected parameters (Key word: DLM, Reproductive toxicity, Sperm quality) (http://www.bvmj.bu.edu.eg) (bvmj, 35 (1): 311-318, SEPT.., 2018)

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Section: Discussionsupporting

confidence: 94%

Biochemical Role of Pyrethroids on Male Fertility and Seminal Profile of Rat

Maksoud

Mahfouz

Soliman

et al. 2018

Benha Veterinary Medical Journal

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“…This decline was attributed to either direct effect of toxicant on androgen biosynthesis pathway in testis or its effect on hypothalamus pituitary gland which might have indirectly affected the testis and sexual function 47 . It was also suggested that pyrethroid insecticides may cause mitochondrial membrane impairment in Leydig cells and disrupt testosterone biosynthesis by diminishing the delivery of cholesterol into the mitochondria and decreasing the conversion of cholesterol to pregnenolone in the cells resulting in reducing subsequent testosterone production 51 . Hence, the reduced testosterone might be responsible for the decreased sperm counts and motility and also morphological abnormality of testis.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, minimal level of testosterone might have led to detachment of germ cells from seminiferous epithelium leading to germ cell apoptosis and reproductive toxicity 51 . Treatment with omega-3 plus β-cyf revealed partial improvement of testis architecture, degenerative changes in the germinal cells and sperm numbers (Fig.…”

Section: Fig 2: Light Micrograph Of the Brain Sections In Male Rat Cmentioning

confidence: 99%

Untitled

2017

IJPSR

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ABSTRACT:The present study was designed to evaluate the protective effect of omega-3 against β-cyfluthrin (β-cyf)-induced neurotransmitters' impairment, oxidative damage, testicular toxicity and genotoxicity. Adult male Wistar rats were divided equally into four groups: Group (I): Control, Group (II): β-cyf (5 mg/kg body weight/day), Group (III): omega-3 (400 mg/kg body weight/da y) + β-cyf (5 mg/kg body weight/day), Group (IV): omega-3 (400 mg/kg body weight/day). β-cyf's treatment for 8 weeks inhibited the activities of AChE, DA, LDH, total ATPase and Na + /K + ATPase. Also, β-cyf resulted in an increase in oxidative stress as indicated by elevations in the levels of MDA and NO while, the levels of TAC, thiol content and TP were decreased in brain and testis. Sperm count, sperm motility and testosterone levels were reduced while, sperm abnormalities, FSH and LH levels were increased in β-cyf-treated group. Also, β-cyf administration led to a significant increase in TNFα, IL-6 and APP mRNA expressions. In addition, β-cyf caused histopathological alterations in brain and testis. The present results showed that omega-3 could improve all the measured parameters. In conclusion, omega-3 could exhibit protective effects against β-cyf induced neurological and testicular damage.

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“…[ 52 ] reported that oral administration of pyrethrum at 200 mg/kg for 23 days to male rats increased body and liver weights with decrease in hepatic DNA concentrations. Other studies reported change in body and organ weights of mice [ 53 ], rats [ 54 , 55 ], and dogs [ 56 ].…”

Section: Adverse Effects Of Natural Insecticides On Experimental Amentioning

confidence: 99%

“…The authors reported significant alteration hepatic pyrethrum metabolism and detoxification enzymes in the liver of male rats. It caused changes in liver enzymes and histopathological alterations in liver tissue in experimental animals such as mice, rats, rabbits, and dogs [ 53 – 56 ]. When rats were fed in feed, containing pyrethrins at 1000 mg/kg.…”

Section: Adverse Effects Of Natural Insecticides On Experimental Amentioning

confidence: 99%

Safety of Natural Insecticides: Toxic Effects on Experimental Animals

Mossa

Mohafrash

Chandrasekaran

2018

BioMed Research International

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Long-term application and extensive use of synthetic insecticides have resulted in accumulating their residues in food, milk, water, and soil and cause adverse health effects to human and ecosystems. Therefore, application of natural insecticides in agriculture and public health sectors has been increased as alternative to synthetic insecticides. The question here is, are all natural insecticides safe. Therefore, the review presented here focuses on the safety of natural insecticides. Natural insecticides contain chemical, mineral, and biological materials and some products are available commercially, e.g., pyrethrum, neem, spinosad, rotenone, abamectin, Bacillus thuringiensis (Bt), garlic, cinnamon, pepper, and essential oil products. It can induce hepatotoxicity, renal toxicity, hematotoxicity, reproductive toxicity, neurotoxicity, and oxidative stress. It can induce mutagenicity, genotoxicity, and carcinogenicity in mammals. Some natural insecticides and active compounds from essential oils are classified in categories Ib (Highly hazardous) to U (unlikely toxic). Therefore, the selectivity and safety of natural insecticides not absolute and some natural compounds are toxic and induce adverse effects to experimental animals. In concussion, all natural insecticides are not safe and the term “natural” does not mean that compounds are safe. In this respect, the term “natural” is not synonymous with “organic” and not all-natural insecticide products are acceptable in organic farmers.

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Evaluation of Deltamethrin induced reproductive toxicity in male Swiss Albino mice

Cited by 25 publications

References 12 publications

Biochemical Role of Pyrethroids on Male Fertility and Seminal Profile of Rat

Biochemical Role of Pyrethroids on Male Fertility and Seminal Profile of Rat

Untitled

Safety of Natural Insecticides: Toxic Effects on Experimental Animals

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