Biochemical Role of Pyrethroids on Male Fertility and Seminal Profile of Rat

Abstract

A B S T R A C TA total number of 80 Wister male rats, 9 -wk. old were taken, weighed and divided into four experimental groups to investigate the effect of Deltamethrin (DLM) oral administration (0.87, 8.7 and 17.4 mg/kg B.W) for a period of 9 weeks on reproductive organs and fertility indices of Wister male rats. The results indicated that DLM caused a significant reduction in Testis weights, sperm count, motility and viability and fructose in semen. Also induced decreases in serum FSH, LH and Estradiol levels however increase in sperm abnormalities. These results indicated that DLM is a toxic pyrethroid pesticide that produced significant reproductive toxicity in treated male rats as revealed by the severely affected parameters (Key word: DLM, Reproductive toxicity, Sperm quality) (http://www.bvmj.bu.edu.eg) (bvmj, 35 (1): 311-318, SEPT.., 2018)

Impairment of the Reproductive System and Mating of Male and Female Black Rats Treated with Lambda-Cyhalothrin Bait and Its Field Application

“…These data are supported by the histological studies which revealed degeneration of the testicular and ovarian cells. These results are in parallel with Abdel-Maksoud et al (2018), Ghosh et al (2018) and Abd El-Hameed and Mahmoud (2020) who indicated that pyrethroids enhance suppression in male and female hormones. Testosterone is important to maintain both of structure and function of the male accessory sex gland.…”

“…It was reported that pyrethroids could affect ovulation causing atresia of follicles, decreasing follicular cells, oocytes and corpora lutea as well as inducing vesicular atrophy of the endometrial glands of mammals (Kotil and Yön, 2015;Marettova et al, 2017). Previous studies have indicated that several pyrethroids induce toxic impacts on the reproduction of mammals (Marettova et al, 2017;Abdel-Maksoud et al, 2018;Zhang et al, 2021;Zhong et al, 2021). Pyrethroids and their metabolites showed toxic effects on the endocrine system causing disturbances in the female hormones of mammals (Fei et al, 2010;Liu et al, 2011;Jurewicz et al, 2020).…”