Evaluation of cytotoxicity for novel composite embolic microspheres: Material optimization by response surface methodology

Composition-property relationships for radiopaque composite materials: pre-loaded drug-eluting beads for transarterial chemoembolization

“…Further evaluation of the RCs delivery characteristics however is warranted, to fully evaluate their clinical utility in the treatment of HCCs. All RCs in this study have excellent cell viability, consistent with the work of Kehoe et al 25 that evaluated the cell viability of microspheres comprising both PLGA and ORP5, in different ratios. From Figure 1, RC extracts have similar cell viabilities to each other as well as that of the control, with no statistically significant difference between any of the compositions.…”

“…Polylactic-co-glycolic acid (PLGA) is an excellent candidate for the polymer component due to its wellknown drug delivery properties from microspheres 23 and its use in the synthesis of glass-polymer composites. 24 Previously, Kehoe et al 25 demonstrated that it was possible to produce PLGA:ORP5 composites through a process of thermally induced phase separation (TIPS). However, the process was not suitable for preloading chemotherapeutic agents, nor did it provide for synthesis of clinically relevant particle size distributions.…”

Predicting the thermal responses and radiopacity of multicomponent zinc–silicate bioglasses: A focus on ZnO, La2O3, SiO2 and TiO2

“…We have previously investigated SiO 2 -CaO-ZnO-La 2 O 3 -TiO 2 -MgOSrO-Na 2 O compositions (as bioactive glasses [1], or as components of composite materials [2]), and have found excellent compatibility in vitro and in vivo for such materials with appropriate tailoring of composition. Synergistically, it has been shown that these compositions (prepared as irregular shaped particles with a particle size distribution of 300-500 μm) posses an intrinsic radiopaque nature [3] and as such, may facilitate the reduced use of contrast media in procedures such as transcatheter arterial embolization (TAE) and transcather arterial chemoembolization (TACE); procedures where embolic particles are frequently used to treat pathologies including (but not limited to) hepatocellular carcinoma, and uterine leiomyomas [4,5].…”

Optimization of sustained release aceclofenac microspheres using response surface methodology

“…In practical terms, the goal of the optimal experiments is to model the true response surface with greater precision and reduce the cost of experimentation. RSM is a collection of statistical and mathematical techniques useful for developing, improving, and optimizing processes in which a response of interest is influenced by several variables and the objective is to optimize this response [19][20][21][22][23].The optimization procedure involved systematic formulations designs to minimize the number of trails, and analyze the response surfaces in order to realize the effect of causal factors and to obtain the appropriate formulations with target goals as well as the acceptable component region as process control conditions in practical preparation [24].…”