Optimization of sustained release aceclofenac microspheres using response surface methodology

Deshmukh, Rameshwar K.; Naik, Jitendra

doi:10.1016/j.msec.2014.12.008

Cited by 28 publications

(4 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The oral bioavailability of aceclofenac could be enhanced using chitosan cocrystals trapped into the alginate matrix as a supersaturated drug delivery system (SDDS) or using polymeric microspheres, which can act as delivery systems for sustained drug release [13,14,15,16]. The production of nanocrystals using the surface solid dispersion technique is also an appropriate method to improve the dissolution rate of aceclofenac [17,18].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs

et al. 2019

View full text Add to dashboard Cite

Aceclofenac-loaded poly(vinyl-pyrrolidone)-based nanofiber formulations were prepared by electrospinning to obtain drug-loaded orally disintegrating webs to enhance the solubility and dissolution rate of the poorly soluble anti-inflammatory active that belongs to the BCS Class-II. Triethanolamine-containing ternary composite of aceclofenac-poly(vinyl-pyrrolidone) nanofibers were formulated to exert the synergistic effect on the drug-dissolution improvement. The composition and the electrospinning parameters were changed to select the fibrous sample of optimum fiber characteristics. To determine the morphology of the nanofibers, scanning electron microscopy was used. Fourier transform infrared spectroscopy (FT-IR), and differential scanning calorimetry (DSC) were applied for the solid-state characterization of the samples, while the drug release profile was followed by the in vitro dissolution test. The nanofibrous formulations had diameters in the range of few hundred nanometers. FT-IR spectra and DSC thermograms indicated the amorphization of aceclofenac, which resulted in a rapid release of the active substance. The characteristics of the selected ternary fiber composition (10 mg/g aceclofenac, 1% w/w triethanolamine, 15% w/w PVPK90) were found to be suitable for obtaining orally dissolving webs of fast dissolution and potential oral absorption.

show abstract

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs

et al. 2019

View full text Add to dashboard Cite

show abstract

“…These microparticle dosage forms can be advantageously used for treating skin cancer. The main objective of this study was to elaborate microspheres of p-aminobenzoic acid (PABA) for sustained release using microencapsulation by the solvent evaporation method [12][13][14][15][16][17][18][19][20] and to study the effects of process parameters, such as stirring Scheme 1. Forms of p-aminobenzoic acid at different pH values.…”

Section: Introductionmentioning

confidence: 99%

Effect of the formulation parameters on the encapsulation efficiency and release behavior of p-aminobenzoic acid-loaded ethylcellulose microspheres

Mouffok

Mesli

Abdelmalek

et al. 2016

JSCS

View full text Add to dashboard Cite

In the current study, p-aminobenzoic acid-loaded ethylcellulose microspheres were prepared under various conditions by solvent evaporation method (o/w). This preparation was carried out with different p-aminobenzoic acid:ethylcellulose (PABA:EC) ratios, stirring speed, surfactant nature and concentration in order to investigate their effect on encapsulation efficiency and drug release kinetics. Scanning Electron Microscopy (SEM) studies showed spherical microspheres with a porous surface and different structures. The mean diameter of Sauter (d32) of these microparticles is in the range from 47 to 165 ?m with PVA and from 793 to 870 ?m with Tween 80 by adjusting process parameters. However, the encapsulation efficiency varied from 37.52 to 79.05 % suitable for the adjustment of a p-aminobenzoic acid with pro-longed release. Microspheres were characterized by FTIR, DSC and XRD. The release of cation of p-aminobenzoic acid was performed in simulated gastric medium at pH 1.2 and 37?0.5?C by UV-VIS analysis to estimate its content. The release data were best fitted to Higuchi model with high correlation coefficient (r?) and the obtained values of n from Korsmeyer-Peppas showed that the drug release follows the Fickian diffusion mechanism.

show abstract

“…The selected natural polymer of current research has unique property of gel formation in aqueous environment on reaction with calcium ions, due to binding of calcium ions with blocks of adjacent alginate chains forming inter-ionic bridges. So, fabrication of microspheres was done by iongelation technique using natural and synthetic polymers for poorly water-soluble drug aceclofenac, due to their non-toxicity, ease of fabrication, high drug entrapment efficiency rate and economical method [9][10][11][12] . The present research study involved fabrication and characterization of aceclofenac microspheres using natural and synthetic polymers by employing response surface methodology and implementing Box-Behnken Design (BBD), as till date there is no such method available in literature that incorporates present employed parameters together.…”

mentioning

confidence: 99%

Response Surface Method Assisted Fabrication and Characterization of Optimized Aceclofenac Loaded Microspheres Inculcated with Multivariate Polymers

Quazi¹,

Khanam²

2022

IJPS

View full text Add to dashboard Cite

Quazi et al.: Fabrication and Characterization of Optimized Aceclofenac Loaded MicrospheresThe optimized microspheres were fabricated as a controlled release system for aceclofenac incorporating polymeric cross-linking with sodium alginate as natural, hydrophilic polymer and Eudragit RS100 synthetic, hydrophobic polymer by ion-gelation technique. The method was optimized by Box Behnken design incorporating concentration of pure drug, natural and synthetic polymer along with the obtained responses that were mean particle size (Y1) and entrapment efficiency of drug (Y2). Microspheres were characterized for percentage yield, micromeritic evaluation, particle size, entrapment efficiency of drug, in vitro study, fourier transform infrared spectroscopy, scanning electron microscopy, nuclear magnetic resonance and high performance liquid chromatography quantification of optimized formulation. It was observed that application of response surface method software for Box Behnken design yielded stable and spherical microspheres with mean particle size 69.37 µm and entrapment efficiency of drug 79.86 % for the most optimized formulation F5. We can conclude that bridging of aceclofenac with natural and synthetic polymers yielded stable, cost effective microspheres bearing enhanced micromeritic properties with controlled release effect.

show abstract

Optimization of sustained release aceclofenac microspheres using response surface methodology

Cited by 28 publications

References 46 publications

Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs

Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs

Effect of the formulation parameters on the encapsulation efficiency and release behavior of p-aminobenzoic acid-loaded ethylcellulose microspheres

Response Surface Method Assisted Fabrication and Characterization of Optimized Aceclofenac Loaded Microspheres Inculcated with Multivariate Polymers

Contact Info

Product

Resources

About