Evaluation of Correlations between Underlying Disease and Port Complications

Teichgräber, Ulf; Nagel, Sebastian N.; Kausche, Stephan

doi:10.1055/s-0033-1356040

Cited by 9 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We speculate that these points could decrease the incidence of venous thrombosis in the present study. Among the many types of malignancies, pancreatic and lung cancers were reported as significant predictors of venous thrombosis and catheter-related thrombotic events (19,20). Both cancers were associated with significantly higher incidence of thrombosis after placement of the TIVAP in the present study compared with other cancer types.…”

Section: Discussionsupporting

confidence: 42%

Characteristics of Symptomatic Axillary Vein Thrombosis After Placement of Totally Implanted Venous Access Port in Cancer Patients

2020

View full text Add to dashboard Cite

Background: The incidence of venous thrombosis based on access route after implantation of the totally implanted venous access port (TIVAP) is controversial. Symptomatic TIVAP-related venous thrombosis remains relatively rare. However, characteristics of symptomatic axillary vein thrombosis after TIVAP implantation via access of the axillary vein has not been reported. Objectives: In this historical cohort study, the incidence and characteristics of venous thrombosis associated with TIVAP via the axillary vein in cancer patients were evaluated. Patients and Methods: A total of 4,773 TIVAPs were placed via the axillary vein in patients with various types of cancer between May 2012 and July 2018. Eighteen patients experienced symptomatic venous thrombosis associated with TIVAPs. Radiologic findings for venous thrombosis were evaluated using computed tomography (CT) including scans of the axillary vein. Medical records were retrospectively reviewed. Results: The prevalence of symptomatic thrombosis was 0.38% (18/4,773). The patients with symptomatic venous thrombosis included 14 males and four females. Among the 18 patients, the most common types of cancer were lung cancer (n = 7) and pancreatic cancer (n = 4), with the incidence rates of 0.79% (lung cancer, 7/882) and 1.58% (pancreatic cancer, 4/253), respectively. The median time between placement of the TIVAP and diagnosis of thrombosis was 35.5 days (range: 6 - 292 days). All symptomatic patients had thrombosis in the axillary vein on CT images. Symptoms were improved in all patients with treatment including removal of TIVAP at the time of diagnosis and following anticoagulation therapy. From the multiple binary logistic regression, pancreatic cancer and lung cancer were statistically significant risk factors of symptomatic axillary vein thrombosis. Conclusion: After insertion of TIVAPs through the axillary vein, symptomatic axillary vein thrombosis rarely developed. Pancreatic cancer and lung cancer were associated with the risk of symptomatic axillary vein thrombosis.

show abstract

Section: Discussionsupporting

confidence: 42%

Characteristics of Symptomatic Axillary Vein Thrombosis After Placement of Totally Implanted Venous Access Port in Cancer Patients

2020

View full text Add to dashboard Cite

show abstract

“…IPT has been the second major long-term complication of catheter use in cancer patients after infection 4 . Patients with cancer have 5-time higher risk of thrombosis than patients with no cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Much research on IPT risk factors has already been reported, such as smoking, comorbidities, biology and underlying disease, and related catheter/technique 11 . In a retrospective study evaluating the correlation between the underlying disease and the port complications, pancreatic and gastric cancers were significantly associated with thrombosis occurrence 4 . A prospective observational cohort study published by Hohl Moinat et al 16 identified high Khorana risk score and lung cancer as indicators of venous thrombotic events and catheter-related thrombotic events.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Implantable port thrombosis in cancer patients: a monocentric experience

Dridi

Mejri

Labidi

et al. 2016

Cancer Biology &Amp; Medicine

View full text Add to dashboard Cite

Objective:Implantable port thrombosis (IPT) in cancer patients is a relatively rare but severe complication. Several factors are reportedly associated with the occurrence of thrombosis. We aimed to describe the prevalence and the anatomoclinical features of IPT observed in cancer patients who were treated in a medical oncology department in Tunisia.Methods:A total of 600 cancer patients who had port implantation from January 2013 to December 2015 were retrospectively identified. Cases with symptomatic/incidental IPT (radiologically confirmed) were further identified. Epidemiological and anatomoclinical features were collected from patient records and the department database.Results: We observed that 33 of the 600 patients had IPT; thus, the prevalence was 5.5%. The median age was 57 years, and the gender ratio was 0.43. Overweight or obesity was observed in 73% of the patients. IPT occurred mainly in patients with breast (36.4%) and colorectal (33.3%) cancers, which were mostly nonmetastatic (79%). At least one identified classical thromboembolic risk factor was found in 13 patients (smoking in 9, tamoxifen in 2). IPT was symptomatic in 93% of the cases, occurring within an average time of 56 days. Implantable ports were removed because of infection in 2 cases and nonfunctionality in 3 cases. IPT treatment was based on low-molecular-weight heparins (94%) and antivitamin K (6%) for an average of 130 days. Four patients had post-therapy complications: one thrombosis recurrence and three infections.Conclusions:IPT cases in the 600 patients were observed to occur in obese nonmetastatic cancer patients within the first 3 months after IP implantation.

show abstract

“…In addition, certain malignancies, such as pancreatic and gastric cancers, are associated with increased risk developing port-related complications. 4,5,9…”

Section: Introductionmentioning

confidence: 99%

Investigation of Complications Following Port Insertion in a Cancer Patient Population: A Retrospective Analysis

Skelton

Franke

Welniak

et al. 2019

Clin Med Insights Oncol

View full text Add to dashboard Cite

Central venous access devices, specifically implantable ports, play an essential role in the care of oncology patients; however, complications are prevalent. This retrospective single-institutional review was performed to identify rates of complications from port placement and potential factors associated with these events. A retrospective analysis of 539 cancer patients who underwent port insertion between March 2016 and March 2017 at our institution was conducted. Data examining 18 potentially predictive factors were collected, and multivariate analysis was conducted using logistic regression and odds ratios (ORs) with standard errors to determine predictive factors. Out of 539 patients, 100 patients (19%) experienced 1 complication, and 12 patients (2%) experienced 2 or more complications. An overall lower rate of complications was seen in patients on therapeutic anticoagulation (OR: 0.17, P < .001) or on antiplatelet agents (OR: 0.47, P = .02). No patients on therapeutic anticoagulation developed venous thromboembolism (VTE; 0%). Right-sided port insertion was associated with decreased rates of infection (OR: 0.44, P = .04). Insertion as inpatient was associated with an increased risk for mechanical failure (OR: 4.60, P < .01). This analysis identified multiple predictive factors that can potentially put patients at a higher risk of experiencing complications following port insertion. Our data show lower rates of VTE for patients on anticoagulation or antiplatelet therapy. Further analysis is also necessary to determine why port insertion as an inpatient places patients at a higher risk of complications. This study highlights the risks associated with port placement and prompts the clinician to have an informed discussion with the patient weighing the risks and benefits.

show abstract

Evaluation of Correlations between Underlying Disease and Port Complications

Cited by 9 publications

References 13 publications

Characteristics of Symptomatic Axillary Vein Thrombosis After Placement of Totally Implanted Venous Access Port in Cancer Patients

Characteristics of Symptomatic Axillary Vein Thrombosis After Placement of Totally Implanted Venous Access Port in Cancer Patients

Implantable port thrombosis in cancer patients: a monocentric experience

Investigation of Complications Following Port Insertion in a Cancer Patient Population: A Retrospective Analysis

Contact Info

Product

Resources

About