Evaluation of complete blood count parameters to predict endometrial cancer

Abstract

Mean corpuscular volume and red cell distribution width are bio-markers that we can use as the predictive marker in patients with endometrial carcinoma and which are cheap, repeatable, and readily obtainable from complete blood count panels and promising.

Preoperative Haematologic Markers for the Differentiation of Endometrial Cancer from Benign Endometrial Lesions in Postmenopausal Patients with Endometrial Masses

“… 23 However, other researchers failed to find any meaningful difference between NLR values in benign and malignant endometrial groups. 15 , 22 , 36 In the present study, the NLR was higher in the EC group than in the benign group (p=0.016), which is in line with prior studies. Bacanakgil et al reported that an NLR of ≥ 4 significantly differentiated endometrial pathologies before intervention in patients with abnormal uterine bleeding.…”

Relation of Mean Platelet Volume (MPV) with Cancer: A Systematic Review with a Focus on Disease Outcome on Twelve Types of Cancer

“…Eight studies relating MPV to endometrial cancer were identified, including 1707 patients from China and Turkey [ 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 ] ( Table 4 ). In all studies, including a control group, MPV was increased in cancer versus healthy patients [ 66 , 67 , 69 , 70 , 71 , 73 ].…”

“…Eight studies relating MPV to endometrial cancer were identified, including 1707 patients from China and Turkey [ 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 ] ( Table 4 ). In all studies, including a control group, MPV was increased in cancer versus healthy patients [ 66 , 67 , 69 , 70 , 71 , 73 ]. The relation of MPV with cancer staging was less clear, as in two studies, no relation was found [ 68 , 71 ] and in one study, MPV was negatively related to the cancer stage [ 67 ].…”

“…The aim of this systematic review was to investigate the alterations of MPV in various types of cancer in relation to healthy subjects and to assess the relation of MPV to disease outcomes according to data published from 2010 to 2022. In total, 83 studies with 21,034 participants and 12 different types of cancer were included, i.e., gastric cancer [ 15 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ], colon cancer [ 13 , 19 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ], esophageal squamous cell carcinoma [ 20 , 47 , 48 , 49 , 50 ], renal cancer [ 18 , 51 , 52 ], breast cancer [ 16 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ], ovarian cancer [ 60 , 61 , 62 , 63 , 64 , 65 ], endometrial cancer [ 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 ], thyroid cancer [ 14 …”

Clinical application of red cell distribution width, mean platelet volume, and cancer antigen 125 detection in endometrial cancer

“…The patients included in this study were pathologically diagnosed with endometrial cancer, and they did not receive any treatment before diagnosis. Blood samples were taken from the patients with the complaint of abnormal uterine bleeding, and all samples were taken before the endometrial biopsy performed 9 . The following patients were excluded: those with blood disease, diabetes mellitus, kidney disease, acute inflammation, anemia, and cardiovascular disease; those who have recently undergone iron therapy and blood transfusion (within the last 3 months); and those with venous thrombosis for >6 months.…”