Evaluation of Competing Process Concepts for the Production of Pure Enantiomers

Abstract

Various promising concepts exist for improving the performance of productions of pure enantiomers. An efficient approach is developed for the systematic conceptual design of such processes. The proposed three-step procedure aids a fast selection of the optimal process configuration out of many possible candidates and leads to an optimally designed process. The approach is applied in a case study for an industrially relevant compound, considering different process concepts based on simulated moving bed chromatography, enantioselective crystallization, and racemization. It is demonstrated that mixed-integer nonlinear programming is capable of predicting simultaneously the optimal process configuration and optimal design parameters.

Deterministic global optimization in conceptual process design of distillation and melt crystallization

“…given implicitly by the model description and are used here to write additional explicit conditions (16) to (18) for the fixed points y rect * , x rect * , y strip * , x strip * ∈ [0, 1] of the recursion formulas (4) and (8), given by Equations (19) and (20).…”

“…A summary of their work in the context of conceptual design of distillation-based hybrid separation processes is presented in a recent review M a n u s c r i p t by [13]. A similar approach was also applied by Franke et al [14,15] to the design of hybrid separation processes based on distillation and melt crystallization and by Kaspereit et al [16] to the design of hybrid processes for the production of pure enantiomers.…”

Dynamics and Control of Coupled Continuous Chromatography and Crystallization Processes for the Production of Pure Enantiomers

“…This, however, was beyond the scope of this work. Finally, also an extension to other process combinations for the production of pure enantiomers [36] seems feasible.…”

Verfahren zur Enantiomerentrennung

“…Mit dem Ziel, das Potenzial solcher Hybridverfahren aus Chromatographie und Kristallisation systematischer und effizienter zu analysieren und zu bewerten, wurden "Short-CutMethoden" entwickelt. [275,304,305] Ein Vergleich konkurrierender Konzepte ist für das Beispiel Bicalutamid in Abbildung 35 gegeben. Die Ergebnisse zeigen, dass im Vergleich zum allein betriebenen SMB-Prozess mit dem gekoppelten Prozess bei einer "SMB-Übergabereinheit" von 92 % eine mehr als doppelt so hohe Produktivität der Gewinnung von R-Bicalutamid mçglich ist.…”