Evaluation of comparative cytotoxicity of spray-type chemicals used in household products

Kwon, Jung-Taek; Seo, Gyun-Baek; Kim, Hyun-Mi; Shim, Ilseob; Lee, Byoungcheun; Jung, Ji‐Youn; Kim, Pilje; Choi, Kyunghee

doi:10.1007/s13273-013-0008-1

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…For hygiene and personal care products such as mouthwashes, toothpastes, and antiseptic creams, cationic actives such as cetyl-pyridinium chloride (CPC) are widely used. While these actives are potent against a wide range of microorganisms, they tend to be highly toxic to mammalian cells, with potentially other adverse health impacts. − …”

Section: Introductionmentioning

confidence: 99%

Effects of Conventional Surfactants on the Activity of Designed Antimicrobial Peptide

et al. 2020

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In this paper, the interaction between a designed antimicrobial peptide (AMP) G(IIKK) 3 I-NH 2 (G 3 ) and four typical conventional surfactants (SDS, C 16 TAB, C 12 EO 23 and C 14 DMAO) have been studied through surface tension measurement, circular dichroism (CD) spectroscopy. The antimicrobial activities of AMP/surfactant cytotoxicity to NIH 3T3 and HSF cells although G 3 is nontoxic to cells. Cationic AMPs can be formulated with nonionic, cationic and zwitterionic surfactants during product development, but care must be taken when AMPs are formulated with anionic surfactants, as the strong electrostatic interaction may undermine their antimicrobial activity.

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Section: Introductionmentioning

confidence: 99%

Effects of Conventional Surfactants on the Activity of Designed Antimicrobial Peptide

et al. 2020

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“…This assay was modified and used as previously described [12]. Briefly, cells were seeded (500/well) in 6-well plates and allowed to adhere overnight.…”

Section: Clonogenic Assaymentioning

confidence: 99%

“…Cells were treated with various mix ratios (total 10 µg/ml) and incubated for 7 days. Our previous study showed that BIT, CTR, and TCS treatment inhibited the growth of lung epithelial cells [12]. In particular, cell growth was severely inhibited in the presence of 5 µM BIT (approximately 0.8 µg/ml).…”

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confidence: 94%

“…However, inhalation of TCS has been reported to lead to lung inflammation and irritation of the respiratory system [10]. Furthermore, our previous studies have shown that a single intratracheal instillation of TCS induced acute lung inflammation in rats [11], and that TCS and BIT were more cytotoxic than CTR to lung epithelial cells [12]. In addition, compared to TCS and CTR, BIT clearly inhibited cell growth.…”

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confidence: 99%

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Cytotoxic Effects of Air Freshener Biocides in Lung Epithelial Cells

Kwon

Lee

Seo

et al. 2013

Natural Product Communications

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This study evaluated the cytotoxicity of mixtures of citral (CTR) and either benzisothiazolinone (BIT, Mix-CTR-BIT) or triclosan (TCS, Mix-CTR-TCS) in human A549 lung epithelial cells. We investigated the effects of various mix ratios of these common air freshener ingredients on cell viability, cell proliferation, reactive oxygen species (ROS) generation, and DNA damage. Mix-CTR-BIT and Mix-CTR-TCS significantly decreased the viability of lung epithelial cells and inhibited cell growth in a dose-dependent manner. In addition, both mixtures increased ROS generation, compared to that observed in control cells. In particular, cell viability, growth, and morphology were affected upon increase in the proportion of BIT or TCS in the mixture. However, comet analysis showed that treatment of cells with Mix-CTR-BIT or Mix-CTR-TCS did not increase DNA damage. Taken together, these data suggested that increasing the content of biocides in air fresheners might induce cytotoxicity, and that screening these compounds using lung epithelial cells may contribute to hazard assessment.

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Didecyldimethylammonium chloride induces oxidative stress and inhibits cell growth in lung epithelial cells

Kwon

Kim

et al. 2014

Mol. Cell. Toxicol.

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Evaluation of comparative cytotoxicity of spray-type chemicals used in household products

Cited by 6 publications

References 14 publications

Effects of Conventional Surfactants on the Activity of Designed Antimicrobial Peptide

Effects of Conventional Surfactants on the Activity of Designed Antimicrobial Peptide

Cytotoxic Effects of Air Freshener Biocides in Lung Epithelial Cells

Didecyldimethylammonium chloride induces oxidative stress and inhibits cell growth in lung epithelial cells

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