Evaluation of Common Structural Brain Changes in Aging and Alzheimer Disease with the Use of an MRI-Based Brain Atrophy and Lesion Index: A Comparison Between T1WI and T2WI at 1.5T and 3T

Guo, Hui; Song, Xiaowei; Vandorpe, Robert; Zhang, Y.; Chen, Wei; Zhang, N.; Schmidt, Matthias; Rockwood, Kenneth

doi:10.3174/ajnr.a3709

Cited by 29 publications

(52 citation statements)

References 35 publications

(49 reference statements)

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“…Guo et al . evaluated the same parameters using 1.5‐ and 3‐T MRI, which is closer to the technical environment of our study. The comparison of the Brain Atrophy and Lesion Index score for patients with AD showed that the T2WI sequence was superior compared with the T1WI sequence for all magnetic fields.…”

Section: Discussionmentioning

confidence: 88%

“…Although these results seem to be in accordance with the conclusions of Guo et al . , they should be moderated by the fact that almost every analysis made with the Steiger test was not statistically significant.…”

Section: Discussionmentioning

confidence: 98%

“…This was clearly demonstrated by Guo et al . , who explained that the T2WI sequence shows increased sensitivity for small lesion detection due to a greater image contrast, despite the higher spatial resolution of the T1WI sequence. This could also explain our results, as visual evaluation was based on the rating of two brain structures containing cerebrospinal fluid, i.e.…”

Section: Discussionmentioning

confidence: 99%

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T1‐ or T2‐weighted magnetic resonance imaging: what is the best choice to evaluate atrophy of the hippocampus?

Fischbach-Boulanger

Fitsiori

Noblet

et al. 2018

Euro J of Neurology

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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T1‐ or T2‐weighted magnetic resonance imaging: what is the best choice to evaluate atrophy of the hippocampus?

Fischbach-Boulanger

Fitsiori

Noblet

et al. 2018

Euro J of Neurology

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“…Meanwhile, higher Cho / Cr was associated with worse domain-specific cognitive performance, which was independent of A β load, suggesting the involvement of additional pathologies [132]. Indeed, disease related metabolite changes in the white matter have been suggested by a number of studies [87, 113, 121, 132], largely reflecting their involvement in both vascular cognitive impairment and AD [133-135]. …”

Section: Resultsmentioning

confidence: 99%

Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease

Zhang¹,

Song²,

Bartha³

et al. 2014

CAR

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Alzheimer’s disease (AD) affects several important molecules in brain metabolism. The resulting neurochemical changes can be quantified non-invasively in localized brain regions using in vivo single-voxel proton magnetic resonance spectroscopy (SV 1H MRS). Although the often heralded diagnostic potential of MRS in AD largely remains unfulfilled, more recent use of high magnetic fields has led to significantly improved signal-to-noise ratios and spectral resolutions, thereby allowing clinical applications with increased measurement reliability. The present article provides a comprehensive review of SV 1H MRS studies on AD at high magnetic fields (3.0 Tesla and above). This review suggests that patterned regional differences and longitudinal alterations in several neurometabolites are associated with clinically established AD. Changes in multiple metabolites are identifiable even at early stages of AD development. By combining information of neurochemicals in different brain regions revealing either pathological or compensatory changes, high field MRS can be evaluated in AD diagnosis and in the detection of treatment effects. To achieve this, standardization of data acquisition and analytical approaches is needed.

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“…In addition, although we used the total CERAD score in our study, we did not correlate different components of the score including verbal fluency, naming, word list immediate/delayed recall, constructional praxis, constructional praxis recall, and the Mini Mental State Examination (MMSE) due to the relatively small number of cases. We also used 1.5 Tesla MRI, however we do not consider it a significant limitation as prior studies have shown that the 1.5T and 3 T MRI are highly correlated in brain atrophy and WMH in aging and AD [44]. Despite these limitations, to our knowledge, ours is the only study correlating both WMH and GM atrophy with longitudinal changes in CERAD score.…”

Section: Discussionmentioning

confidence: 99%

Correlating Cognitive Decline with White Matter Lesion and Brain Atrophy Magnetic Resonance Imaging Measurements in Alzheimer’s Disease

Bilello

Doshi

Nabavizadeh

et al. 2015

JAD

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Background Vascular risk factors are increasingly recognized as risks factors for Alzheimer’s disease (AD) and early conversion from mild cognitive impairment (MCI) to dementia. While neuroimaging research in AD has focused on brain atrophy, metabolic function or amyloid deposition, little attention has been paid to the effect of cerebrovascular disease to cognitive decline. Objective To investigate the correlation of brain atrophy and white matter lesions with cognitive decline in AD, MCI, and control subjects. Methods Patients with AD and MCI, and healthy subjects were included in this study. Subjects had a baseline MRI scan, and baseline and follow-up neuropsychological battery (CERAD). Regional volumes were measured, and white matter lesion segmentation was performed. Correlations between rate of CERAD score decline and white matter lesion load and brain structure volume were evaluated. In addition, voxel-based correlations between baseline CERAD scores and atrophy and white matter lesion measures were computed. Results CERAD rate of decline was most significantly associated with lesion loads located in the fornices. Several temporal lobe ROI volumes were significantly associated with CERAD decline. Voxel-based analysis demonstrated strong correlation between baseline CERAD scores and atrophy measures in the anterior temporal lobes. Correlation of baseline CERAD scores with white matter lesion volumes achieved significance in multilobar subcortical white matter. Conclusion Both baseline and declines in CERAD scores correlate with white matter lesion load and gray matter atrophy. Results of this study highlight the dominant effect of volume loss, and underscore the importance of small vessel disease as a contributor to cognitive decline in the elderly.

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Evaluation of Common Structural Brain Changes in Aging and Alzheimer Disease with the Use of an MRI-Based Brain Atrophy and Lesion Index: A Comparison Between T1WI and T2WI at 1.5T and 3T

Cited by 29 publications

References 35 publications

T1‐ or T2‐weighted magnetic resonance imaging: what is the best choice to evaluate atrophy of the hippocampus?

T1‐ or T2‐weighted magnetic resonance imaging: what is the best choice to evaluate atrophy of the hippocampus?

Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease

Correlating Cognitive Decline with White Matter Lesion and Brain Atrophy Magnetic Resonance Imaging Measurements in Alzheimer’s Disease

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