T1‐ or T2‐weighted magnetic resonance imaging: what is the best choice to evaluate atrophy of the hippocampus?

Fischbach-Boulanger, C.; Fitsiori, Aikaterini; Noblet, Vincent; Baloglu, Seyyid; Oesterlé, Hélène; Drăghici, Sorin; Philippi, Nathalie; Duron, Emmanuelle; Hanon, Olivier; Dietemann, J L; Blanc‬, ‪Frederic; Kremer, Stéphane

doi:10.1111/ene.13601

Cited by 4 publications

(4 citation statements)

References 29 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The correlation between FreeSurfer hippocampal volumes and MTA was moderate, but a weaker correlation, yet still statistically significant, was observed for manual volumetry. Our results, based on a heterogeneous study population, are in line with previous studies, with similar modest correlations between manual volumetry and MTA [ 22 – 24 ], and higher correlations in studies using (semi-)automated methods, such as FreeSurfer or NeuroQuant [ 25 , 26 ]. Despite such findings, good agreement of hippocampal volumes has been reported between FreeSurfer and manual volumetry [ 41 , 42 ], although different definitions of anatomical boundaries lead to a bias with larger FreeSurfer volumes than manually determined volumes [ 43 ].…”

Section: Discussionsupporting

confidence: 92%

Validity and reliability of the medial temporal lobe atrophy scale in a memory clinic population

et al. 2021

View full text Add to dashboard Cite

Background Visual rating of medial temporal lobe atrophy (MTA) is often performed in conjunction with dementia workup. Most prior studies involved patients with known or probable Alzheimer’s disease (AD). This study investigated the validity and reliability of MTA in a memory clinic population. Methods MTA was rated in 752 MRI examinations, of which 105 were performed in cognitively healthy participants (CH), 184 in participants with subjective cognitive impairment, 249 in subjects with mild cognitive impairment, and 214 in patients with dementia, including AD, subcortical vascular dementia and mixed dementia. Hippocampal volumes, measured manually or using FreeSurfer, were available in the majority of cases. Intra- and interrater reliability was tested using Cohen’s weighted kappa. Correlation between MTA and quantitative hippocampal measurements was ascertained with Spearman’s rank correlation coefficient. Moreover, diagnostic ability of MTA was assessed with receiver operating characteristic (ROC) analysis and suitable, age-dependent MTA thresholds were determined. Results Rater agreement was moderate to substantial. MTA correlation with quantitative volumetric methods ranged from -0.20 (p< 0.05) to -0.68 (p < 0.001) depending on the quantitative method used. Both MTA and FreeSurfer are able to distinguish dementia subgroups from CH. Suggested age-dependent MTA thresholds are 1 for the age group below 75 years and 1.5 for the age group 75 years and older. Conclusions MTA can be considered a valid marker of medial temporal lobe atrophy and may thus be valuable in the assessment of patients with cognitive impairment, even in a heterogeneous patient population.

show abstract

Section: Discussionsupporting

confidence: 92%

Validity and reliability of the medial temporal lobe atrophy scale in a memory clinic population

et al. 2021

View full text Add to dashboard Cite

show abstract

“…T2w images were preferred over T1w images for hippocampal segmentations due to their better contrast between hippocampal subfields. 26 Additionally, a T1w MRI using Ultrafast Gradient Echo 3D sequence (TR: 2300 ms; TE: 2.96 ms; FoV: 256 mm; flip angle: 9°) with 1-mm isotropic voxels was collected. T1w images were used for initial template registration before using the T2w images for the segmentation.…”

Section: Methodsmentioning

confidence: 99%

Hippocampal subfield associations with memory depend on stimulus modality and retrieval mode

Aumont,

Bussy,

Bedard

et al. 2023

Brain Communications

View full text Add to dashboard Cite

Hippocampal atrophy is a well-known feature of age-related memory decline, and hippocampal subfields may contribute differently to this decline. In this cross-sectional study, we investigated the associations between hippocampal subfield volumes and performance in free recall and recognition memory tasks in both verbal and visual modalities in older adults without dementia. We collected MRIs from 97 (41 males) right-handed participants aged over 60. We segmented the right and left hippocampi into 1) dentate gyrus and cornu ammonis 4 (DG/CA4); 2) CA2 and CA3 (CA2/CA3); 3) CA1; 4) strata radiatum, lacunosum and moleculare (SRLM); and 5) subiculum. Memory was assessed with verbal free recall and recognition tasks, as well as visual free recall and recognition tasks. Amyloid-β and hippocampal tau positivity were assessed using [18F]AZD4694 and [18F]MK6240 PET tracers, respectively. The verbal free recall and verbal recognition performances were positively associated with CA1 and SRLM volumes. The verbal free recall and visual free recall were positively correlated with the right DG/CA4. The visual free recall, but not verbal free recall, was also associated with the right CA2/CA3. The visual recognition was not significantly associated with any subfield volume. Hippocampal tau positivity, but not amyloid-β positivity, was associated with reduced DG/CA4, CA2/CA3 and SRLM volumes. Our results suggest that memory performances are linked to specific subfields. CA1 appears to contribute to the verbal modality, irrespective of the free recall or recognition mode of retrieval. In contrast, DG/CA4 seems to be involved in the free recall mode, irrespective of verbal or visual modalities. These results are concordant with the view that DG/CA4 plays a primary role in encoding a stimulus’ distinctive attributes, and that CA2/CA3 could be instrumental in recollecting a visual memory from one of its fragments. Overall, we show that hippocampal subfield segmentation can be useful for detecting early volume changes and improve our understanding of the hippocampal subfields’ roles in memory.

show abstract

“…Hippocampal atrophy was visually assessed by a radiologist if either (1) the structures of the inner hippocampus were blurred or (2) hippocampus volume was reduced, or (3) the hippocampal fissure was dilated. For this purpose, T2-weighted images of the hippocampus were studied in particular, as these sequences are more suitable for measuring hippocampal atrophy (Fischbach-Boulanger et al, 2018 ). Patients' vascular pathology and lesions corresponded to cerebral microangiopathy assessed by Fazekas et al ( 1987 ) in our study.…”

Section: Methodsmentioning

confidence: 99%

Preserved visuoconstruction in patients with Alzheimer's pathology and anti-neural autoantibodies: A case control study

Hansen¹,

Hirschel²,

Teegen³

et al. 2022

Front. Dement.

View full text Add to dashboard Cite

BackgroundAlzheimer's disease (AD) is seldom reported to be associated with neural autoantibodies apart from those involved in axonal neurodegeneration and amyloidopathy in prior studies. Nevertheless, this is an under-investigated aspect of AD. As we do not know whether additional screening for autoantibodies in AD patients has additional diagnostic and therapeutic value, this study aims to shed light on whether visuoconstructive or figural memory capacities might distinguish these patient populations.MethodsIn this pilot case series, we investigated eight patients suffering from cognitive impairment associated with cerebrospinal fluid (CSF)-based Alzheimer pathology (AP) and with verified anti-neural autoantibodies (AP Aab+) compared to eight AD patients presenting no autoantibodies (Aab–) (AD Aab–). Patients files were reviewed retrospectively regarding their neuropsychological profile assessed via the CERAD (Consortium to Establish a Registry for Alzheimer's Disease) test battery and psychopathology measured by the AMDP (Manual for the Assessment and Documentation of Psychopathology in Psychiatry) system. We also relied on diagnostic parameters as in the CSF and magnetic resonance images.ResultsAll patients shared the same pattern of dysfunctional word-list learning and word-list recall resembling a hippocampus-dependent memory dysfunction. Furthermore, both patient groups revealed a CSF profile concurring with Alzheimer's disease. However, visuoconstructive capacity, but not figure recall was preserved in AP Aab+ patients, but not in AD Ab-patients with the shared hippocampus-based memory dysfunction. We observed no relevant differences between the AP Aab+ and AD Aab– groups in CSF cell-counts or intrathecal IgG synthesis. The relative frequency of hippocampal and focal atrophy did not differ either between AP Aab+ and AD Aab– groups.DiscussionOur pilot findings are encouraging us to conduct large-scale studies to replicate our discovery of preserved visuoconstruction in AP Aab+ patients with hippocampus-based memory dysfunction. The role of anti-neural autoantibodies is still not fully understood. The detection of these autoantibodies might imply another disease pathology that could be either neuroprotective or be affecting other brain regions, i.e., less pronounced disease activity in the right temporo-parietal regions mainly involved in visuoconstruction.

show abstract

T1‐ or T2‐weighted magnetic resonance imaging: what is the best choice to evaluate atrophy of the hippocampus?

Abstract: The present study suggests that T2WI provides a more adequate visual rating of hippocampal atrophy.

Cited by 4 publications

References 29 publications

Validity and reliability of the medial temporal lobe atrophy scale in a memory clinic population

Validity and reliability of the medial temporal lobe atrophy scale in a memory clinic population

Hippocampal subfield associations with memory depend on stimulus modality and retrieval mode

Preserved visuoconstruction in patients with Alzheimer's pathology and anti-neural autoantibodies: A case control study

Contact Info

Product

Resources

About