Evaluation of clinical types of cutaneous lichen planus in anti‐hepatitis C virus seronegative and seropositive Nigerian patients

Daramola, O O M; Ogunbiyi, Adebola; George, A. O.

doi:10.1111/j.1365-4632.2003.01715.x

Cited by 10 publications

(9 citation statements)

References 13 publications

(22 reference statements)

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“…There was no age difference between CLP and HLP patients. However, contrary to Daramola et al (16) findings, the present study has not confirmed the female predominance of LP, as both sexes were almost equally affected by CLP and HLP. This observation is consistent with the findings of other studies as well (25,26).…”

Section: Discussioncontrasting

confidence: 99%

“…The mean age of LP patients in the present study was 37.20±13.39 years, that being in accordance with the previously documented adult age range of 30-60 years (24,25). Similarly, the mean age of patients with LP in this study was very close to 37.13±12.8 years as documented by Daramola et al previously in a similar environment (15)(16)(17) and 38.8 years as documented in India by Bhattacharya et al (26). There was no age difference between CLP and HLP patients.…”

Section: Discussionsupporting

confidence: 92%

“…Few Nigerian studies have detailed the epidemiology of LP (13)(14)(15)(16)(17), but none has examined the differences or peculiarities of CLP and HLP. The main aim of this study is to research into any existing demographic, clinical and histologic differences between CLP and HLP and to determine the clinical correlates of both types of LP among patients attending the Dermatology Clinics of two Nigerian Teaching Hospitals located in southeastern and southwestern Nigeria.…”

Section: Introductionmentioning

confidence: 99%

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Epidemiologic and Clinical Differences Between Classic and Hypertrophic Lichen Planus in Nigeria

Ifeanyi

Akinboro

Ezejoifor

et al. 2019

Serbian Journal of Dermatology and Venereology

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Introduction. Lichen planus is a chronic inflammatory skin disease known to have several clinical variants with attended variable clinical outcomes. Certain complications have been observed in the hypertrophic type, which were not found in association with the classic variant. Objective: To identify the epidemiologic and clinical differences between the classic and hypertrophic lichen planus and clinical correlates. Material and Methods. Of 104 participants with lichen planus included in the study, 49 had classic and 55 hypertrophic lichen planus. Demographic and clinical information was obtained. Diagnosis of lichen planus was made clinically and confirmed with histology. The participants were screened for metabolic syndrome, hepatitis B, and C. Results: Mean age of all patients was 37.20±13.39 years, with no age and gender differences between the participants with classic and hypertrophic lichen planus. Classic lichen planus was more likely to be painful, (8.2% vs 0.0, p=0.046), generalized (95.9% vs 16.4%, p<0.001), involve the oral mucosa (38.8% vs 0.0, p<0.001), the nails (38.8% vs 1.8, p<0.001), present with kobnerisation (55.1% vs 5.5%,<0.001), Wickhiam striae (69.4% vs 16.4%, p<0.001), associated with Hepatitis B vaccination (16.3% vs 3.6%, p<0.028) and anti HCV positivity (16.3% vs 0.0%, p=0.002). Hypertrophic lichen planus was significantly associated with impaired glucose tolerance/diabetes mellitus (16.4% vs 2.0%, p=0.013), dyslipidemia (74.5% vs 40.8%, p=0.001) and saw-tooth histologic appearance compared to classic type. Conclusion: Hypertrophic lichen planus is more likely to be associated with metabolic complications compared to the classic type. Further studies are needed to loink this difference t chronic inflamation.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Epidemiologic and Clinical Differences Between Classic and Hypertrophic Lichen Planus in Nigeria

Ifeanyi

Akinboro

Ezejoifor

et al. 2019

Serbian Journal of Dermatology and Venereology

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“…On the other hand, the outcome of epidemic investigations varies considerably in different geographic regions. In Japan, Italy, Nigeria, Thailand (Nagao et al, 1995;Carrozzo et al, 1996;Figueiredo et al, 2002;Daramola et al, 2003;Klanrit et al, 2003;Lodi et al, 2004), the prevalence of HCV infection in OLP patients ranging from 8.33% to 60% was statistically higher than the controls. However, reports from other areas, such as Holland,Germany, Serbia, Rio de Janeiro (van der Meij et al, 2000;Friedrich et al, 2003;Bokor-Bratic et al, 2004;Cunha et al, 2005) showed no difference in the HCV infection rate between the patients with OLP and the common population.…”

Section: Discussionmentioning

confidence: 94%

The Prevalence of Hepatitis C Virus Infection in Oral Lichen Planus in an Ethnic Chinese Cohort of 232 Patients

et al. 2010

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Aim Oral lichen planush (OLP) is a chronic inflammatory disease, and has been reported to have a correlation with hepatitis C virus (HCV) infection in some regional investigations. In this study, we investigated the prevalence of HCV in patients with oral lichen planus in an ethnic Chinese cohort. Methodology The antibody of HCV infection was detectedby using enzyme-linked immunosorbent assay. Moreover, the clinical characteristics of whole the cohort have also been studied, such as the gender, age, clinical type, habits and social factors. ResultsOf all 232 patients, the antibody of HCV infection was detected positive in 4 patients (1.72%) using enzymelinked immunosorbent assay. It was lower than that in control group of 2.5%, but not significant (P=0.309). The positive rate of HCV antibody in the erosive type ones (4.2%) was higher than that in the reticular type ones (1.0%), but this difference was proved to be not significant (P=0.389). The clinical characteristics of whole cohort, such as the gender, age, clinical type, habits and social factors, showed the outcome obtained in the present study were similar to thao of our previous study.Conclusion HCV may play no etiological role in oral lichen planus in ethnic Chinese OLP patients.

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“…1). Of these, 16 were excluded because they had no control group (descriptive design), one was excluded for including patients without histological diagnosis 10 and one was excluded 11 for reporting data published in a previous article 12 . Results of the current cross‐sectional study were also included.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Lichen planus and hepatitis C virus: a multicentre study of patients with oral lesions and a systematic review

et al. 2004

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SummaryBackground An association between hepatitis C virus (HCV) infection and lichen planus (LP) has been investigated, but results have been inconsistent. Objectives To investigate the relationship between LP and HCV seropositivity. Methods In a cross-sectional study we tested the sera of 303 consecutive newly diagnosed patients with histologically proven LP referred to three Italian centres for the presence of anti-HCV IgG. A comparable control group was also tested. Next, in a systematic review, studies were identified by searching different databases in April 2004. Inclusion criteria were: (i) analytical study design; (ii) clinical and histological diagnosis of LP; and (iii) serological test for anti-HCV antibodies as main outcome. The risk of bias was assessed on the basis of characteristics of the study group, appropriateness of the control group and study design. Pooled data were analysed by calculating odds ratios (ORs), using a random effects model. Results In the cross-sectional study, nearly one in five (19AE1%) of the LP group was HCV positive, while a much lower prevalence of infection was found in the control group (3AE2%) [OR 7AE08; 95% confidence interval (CI) 3AE43-14AE58]. The systematic review yielded 25 relevant studies, six of which had a low risk of bias. There was a statistically significant difference in the proportion of HCV-seropositive subjects among patients with LP, compared with controls (OR 4AE80; 95% CI 3AE25-7AE09). Following subgroup analyses, the variability of HCV prevalence in patients with LP seemed to depend on geographical area, but not on age. Conclusions Anti-HCV circulating antibodies are more common in patients with LP than in controls, although such an association may not be significant in some geographical areas.

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Evaluation of clinical types of cutaneous lichen planus in anti‐hepatitis C virus seronegative and seropositive Nigerian patients

Abstract: Hypertrophic lichen planus in Nigerians is more prevalent with HCV infection.

Cited by 10 publications

References 13 publications

Epidemiologic and Clinical Differences Between Classic and Hypertrophic Lichen Planus in Nigeria

Epidemiologic and Clinical Differences Between Classic and Hypertrophic Lichen Planus in Nigeria

The Prevalence of Hepatitis C Virus Infection in Oral Lichen Planus in an Ethnic Chinese Cohort of 232 Patients

Lichen planus and hepatitis C virus: a multicentre study of patients with oral lesions and a systematic review

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